Question 1

One of the most common forms of liver disease is due to chronic __________.

Accepted Answer

A)  Hyperthyroidism 
B)  Malnutrition 
C)  Alcoholism 
D)  Malignancy 
E)  Drug abuse 
A)  Hyperthyroidism 
B)  Malnutrition 
C)  Alcoholism 
D)  Malignancy 
E)  Drug abuse C

Question 2

Chronic blood loss in a patient with malignancy results in __________ anemia.

Accepted Answer

A)  Hyperchromic 
B)  Hypochromic 
C)  Normochromic 
D)  Infection-associated 
E)  None of the above 
A)  Hyperchromic 
B)  Hypochromic 
C)  Normochromic 
D)  Infection-associated 
E)  None of the above B

Question 3

A Delta check of hemoglobin values for a patient helps with:

Accepted Answer

A)  Anemia of infancy 
B)  Anemia of endocrine disorders 
C)  Anemia due to improperly collected laboratory samples 
D)  Anemia due to liver disease/alcoholism 
A)  Anemia of infancy 
B)  Anemia of endocrine disorders 
C)  Anemia due to improperly collected laboratory samples 
D)  Anemia due to liver disease/alcoholism C

Question 4

In the anemia of inflammation, there is an increase in the erythrocyte sedimentation rate (ESR) due to:

Accepted Answer

A)  Increased fibrinogen 
B)  Decreased fibrinogen 
C)  Decreased globulin 
D)  Decreased albumin 
E)  Decreased transferrin 
A)  Increased fibrinogen 
B)  Decreased fibrinogen 
C)  Decreased globulin 
D)  Decreased albumin 
E)  Decreased transferrin

Question 5

What recombinant cytokine has proven effective in counteracting the suppressing effects of IL-1 in AOI (anemia of inflammation)?

Accepted Answer

A)  EPO (erythropoietin) 
B)  Interferon gamma 
C)  TNF (tumor necrosis factor) 
D)  GM-CSF (granulocyte-macrophage colony-stimulating factor) 
E)  G-CSF (granulocyte colony-stimulating factor) 
A)  EPO (erythropoietin) 
B)  Interferon gamma 
C)  TNF (tumor necrosis factor) 
D)  GM-CSF (granulocyte-macrophage colony-stimulating factor) 
E)  G-CSF (granulocyte colony-stimulating factor)

Question 6

Leukoerythroblastosis with teardrop-shaped red blood cells is indicative of:

Accepted Answer

A)  Bone marrow fibrosis 
B)  Bone marrow stress 
C)  Abnormal lipid metabolism 
D)  Renal disease 
A)  Bone marrow fibrosis 
B)  Bone marrow stress 
C)  Abnormal lipid metabolism 
D)  Renal disease

Question 7

Macrocytosis in liver disease is caused by all of the following except:

Accepted Answer

A)  Abnormal lipid metabolism 
B)  Direct effects of alcohol 
C)  Iron deficiency 
D)  Vitamin B12 and folate deficiency 
E)  B and D are correct 
A)  Abnormal lipid metabolism 
B)  Direct effects of alcohol 
C)  Iron deficiency 
D)  Vitamin B12 and folate deficiency 
E)  B and D are correct

Question 8

Which of the following RBC morphologies is usually seen on the peripheral smear of a patient with renal disease?

Accepted Answer

A)  Spherocytes 
B)  Target cells 
C)  Burr cells 
D)  Drepanocytes 
E)  B and C 
A)  Spherocytes 
B)  Target cells 
C)  Burr cells 
D)  Drepanocytes 
E)  B and C

Question 9

The presence of __________ on a peripheral blood smear often indicates marrow infiltration by a tumor.

Accepted Answer

A)  Leukoerythroblastosis and sickle cells 
B)  Leukoerythroblastosis and teardrop red blood cells (RBCs) 
C)  Leukoerythroblastosis and target cells 
D)  Leukopenia and teardrop red blood cells (RBCs) 
E)  Leukopenia and target cells 
A)  Leukoerythroblastosis and sickle cells 
B)  Leukoerythroblastosis and teardrop red blood cells (RBCs) 
C)  Leukoerythroblastosis and target cells 
D)  Leukopenia and teardrop red blood cells (RBCs) 
E)  Leukopenia and target cells

Question 10

In chronic liver disease, the hematologic picture may demonstrate the presence of:

Accepted Answer

A)  Acanthocytes 
B)  Target cells 
C)  Macrocytes 
D)  All of the above 
E)  None of the above 
A)  Acanthocytes 
B)  Target cells 
C)  Macrocytes 
D)  All of the above 
E)  None of the above

Question 11

Which cytokines are thought of as key pathogenetic factors in AOI (anemia of inflammation)?

Accepted Answer

A)  IL-1 
B)  Erythropoietin 
C)  Ferritin 
D)  Ferrous iron 
E)  Thrombopoietin 
A)  IL-1 
B)  Erythropoietin 
C)  Ferritin 
D)  Ferrous iron 
E)  Thrombopoietin

Question 12

The anemia of inflammation can be differentiated from iron-deficiency anemia by which of the following?

Accepted Answer

A)  Serum iron level 
B)  Bone marrow iron stores 
C)  FEP 
D)  % sideroblasts 
E)  Hematocrit 
A)  Serum iron level 
B)  Bone marrow iron stores 
C)  FEP 
D)  % sideroblasts 
E)  Hematocrit

Question 13

In anemia associated with renal disease, the anemia that develops is the result of inadequate quantity of circulating:

Accepted Answer

A)  Erythropoietin (EPO) 
B)  Thrombopoietin 
C)  Interleukin (IL-1) 
D)  G-CSF 
E)  GM-CSF 
A)  Erythropoietin (EPO) 
B)  Thrombopoietin 
C)  Interleukin (IL-1) 
D)  G-CSF 
E)  GM-CSF

Question 14

Which of the following is characteristic of anemia of inflammation?

Accepted Answer

A)  Decreased red blood cell life span 
B)  Impaired iron metabolism 
C)  Decreased erythropoiesis levels 
D)  Suppression of erythropoiesis 
E)  All of the above 
A)  Decreased red blood cell life span 
B)  Impaired iron metabolism 
C)  Decreased erythropoiesis levels 
D)  Suppression of erythropoiesis 
E)  All of the above

Question 15

The presence of both immature white and red cells on a peripheral smear is referred to as:

Accepted Answer

A)  Leukoerythrocytopenia 
B)  Leukoerythroblastosis 
C)  Leukoerythrocytosis 
D)  Myelophthisic 
E)  Leukopenia 
A)  Leukoerythrocytopenia 
B)  Leukoerythroblastosis 
C)  Leukoerythrocytosis 
D)  Myelophthisic 
E)  Leukopenia

Question 16

__________ is very common in chronic alcoholics and is not accompanied by hypersegmented neutrophils.

Accepted Answer

A)  Spherocytosis 
B)  Macrocytosis 
C)  Microcytosis 
D)  Reticulocytosis 
E)  Megaloblastosis 
A)  Spherocytosis 
B)  Macrocytosis 
C)  Microcytosis 
D)  Reticulocytosis 
E)  Megaloblastosis

Question 17

In the anemia of inflammation it is suggested that one of the reasons for a decreased transferrin saturation may be:

Accepted Answer

A)  Inadequate diet 
B)  Iron is blocked in the fixed macrophages in the bone marrow 
C)  Accumulation of porphyrin precursors in the liver 
D)  Dietary iron is not adsorbed from GI tract 
E)  Transferrin deficiency 
A)  Inadequate diet 
B)  Iron is blocked in the fixed macrophages in the bone marrow 
C)  Accumulation of porphyrin precursors in the liver 
D)  Dietary iron is not adsorbed from GI tract 
E)  Transferrin deficiency

Question 18

What are the typical hematologic findings associated with anemia from endocrine dysfunction?

Accepted Answer

A)  Mild normocytic, normochromic anemia 
B)  Anemia, abnormal platelets, and coagulopathy 
C)  Target cells, macrocytes, and acanthocytes 
D)  Marked anisocytosis and poikilocytosis, and dysfunctional leukocytes 
A)  Mild normocytic, normochromic anemia 
B)  Anemia, abnormal platelets, and coagulopathy 
C)  Target cells, macrocytes, and acanthocytes 
D)  Marked anisocytosis and poikilocytosis, and dysfunctional leukocytes

Question 19

Which of the following lists of laboratory findings would be most characteristic of the anemia of chronic disease?

Accepted Answer

A)  Normocytic, hypochromic anemia; high serum iron level; increased TIBC; decreased ferritin levels 
B)  Normocytic, normochromic anemia; low serum iron level; decreased TIBC; increased ferritin levels 
C)  Microcytic, hypochromic anemia; normal serum iron level; decreased TIBC; normal ferritin levels 
D)  Macrocytic, normochromic anemia; low serum iron level; decreased TIBC; decreased ferritin levels 
A)  Normocytic, hypochromic anemia; high serum iron level; increased TIBC; decreased ferritin levels 
B)  Normocytic, normochromic anemia; low serum iron level; decreased TIBC; increased ferritin levels 
C)  Microcytic, hypochromic anemia; normal serum iron level; decreased TIBC; normal ferritin levels 
D)  Macrocytic, normochromic anemia; low serum iron level; decreased TIBC; decreased ferritin levels

Question 20

Macrocytosis in patients with cirrhosis and obstructive jaundice can be differentiated from the macrocytes seen in megaloblastic anemia because of:

Accepted Answer

A)  An increase in mean corpuscular volume (MCV) 
B)  Absence of hypersegmented neutrophils 
C)  Megaloblastic anemia 
D)  Macro-ovalocytosis 
E)  Leukocytosis 
A)  An increase in mean corpuscular volume (MCV) 
B)  Absence of hypersegmented neutrophils 
C)  Megaloblastic anemia 
D)  Macro-ovalocytosis 
E)  Leukocytosis

Exam 14: Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

One of the most common forms of liver disease is due to chronic __________.

Chronic blood loss in a patient with malignancy results in __________ anemia.

A Delta check of hemoglobin values for a patient helps with:

In the anemia of inflammation, there is an increase in the erythrocyte sedimentation rate (ESR) due to:

What recombinant cytokine has proven effective in counteracting the suppressing effects of IL-1 in AOI (anemia of inflammation)?

Leukoerythroblastosis with teardrop-shaped red blood cells is indicative of:

Macrocytosis in liver disease is caused by all of the following except:

Which of the following RBC morphologies is usually seen on the peripheral smear of a patient with renal disease?

The presence of __________ on a peripheral blood smear often indicates marrow infiltration by a tumor.

In chronic liver disease, the hematologic picture may demonstrate the presence of:

Which cytokines are thought of as key pathogenetic factors in AOI (anemia of inflammation)?

The anemia of inflammation can be differentiated from iron-deficiency anemia by which of the following?

In anemia associated with renal disease, the anemia that develops is the result of inadequate quantity of circulating:

Which of the following is characteristic of anemia of inflammation?

The presence of both immature white and red cells on a peripheral smear is referred to as:

__________ is very common in chronic alcoholics and is not accompanied by hypersegmented neutrophils.

In the anemia of inflammation it is suggested that one of the reasons for a decreased transferrin saturation may be:

What are the typical hematologic findings associated with anemia from endocrine dysfunction?

Which of the following lists of laboratory findings would be most characteristic of the anemia of chronic disease?

Macrocytosis in patients with cirrhosis and obstructive jaundice can be differentiated from the macrocytes seen in megaloblastic anemia because of:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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