Question 1

The cytochemical reactions are performed by applying staining techniques to __________ smears.

Accepted Answer

A)  Peripheral blood 
B)  Bone marrow 
C)  Touch preparation 
D)  All of the above 
E)  None of the above 
A)  Peripheral blood 
B)  Bone marrow 
C)  Touch preparation 
D)  All of the above 
E)  None of the above D

Question 2

A 14-year-old male presents with a mediastinal mass, a WBC of 110 F1F1F1S1F1F1F10 109/L, hepatosplenomegaly, and early central nervous system involvement. Both L1 and L2 morphology are seen, and surface markers CD7, CD2, and CD5 are expressed. Which type of ALL is present?

Accepted Answer

A)  Precursor B-cell 
B)  T-cell 
C)  B-cell 
D)  Null cell 
E)  None of the above 
A)  Precursor B-cell 
B)  T-cell 
C)  B-cell 
D)  Null cell 
E)  None of the above B

Question 3

Which host factor(s) is/are associated with an increased risk of developing leukemia?

Accepted Answer

A)  Chromosomal abnormalities 
B)  Immunodeficiency states 
C)  Chronic marrow dysfunction syndromes 
D)  Inherited predisposition 
E)  All of the above 
A)  Chromosomal abnormalities 
B)  Immunodeficiency states 
C)  Chronic marrow dysfunction syndromes 
D)  Inherited predisposition 
E)  All of the above E

Question 4

A strong PAS reaction supports the diagnosis of __________.

Accepted Answer

A)  Sickle cell anemia 
B)  Type L3 ALL 
C)  Pernicious anemia 
D)  Erythroleukemia 
E)  None of the above 
A)  Sickle cell anemia 
B)  Type L3 ALL 
C)  Pernicious anemia 
D)  Erythroleukemia 
E)  None of the above

Question 5

Cell __________ is used to distinguish between acute and chronic forms of leukemia.

Accepted Answer

A)  Maturity 
B)  Lineage 
C)  Count 
D)  Kinetics 
E)  None of the above 
A)  Maturity 
B)  Lineage 
C)  Count 
D)  Kinetics 
E)  None of the above

Question 6

The presence of Auer rods in the cytoplasm of cells rules out __________.

Accepted Answer

A)  ALL 
B)  AML 
C)  Myelodysplastic syndrome 
D)  Acute promyelocytic leukemia 
E)  None of the above 
A)  ALL 
B)  AML 
C)  Myelodysplastic syndrome 
D)  Acute promyelocytic leukemia 
E)  None of the above

Question 7

Anemia in acute leukemia is generally __________.

Accepted Answer

A)  Microcytic/normochromic 
B)  Normocytic/normochromic 
C)  Microcytic/hypochromic 
D)  Macrocytic/normochromic 
E)  None of the above 
A)  Microcytic/normochromic 
B)  Normocytic/normochromic 
C)  Microcytic/hypochromic 
D)  Macrocytic/normochromic 
E)  None of the above

Question 8

Which percentage of blasts does the WHO classification system recommend for a diagnosis of acute leukemia?

Accepted Answer

A)  10% 
B)  20% 
C)  30% 
D)  25% 
E)  15% 
A)  10% 
B)  20% 
C)  30% 
D)  25% 
E)  15%

Question 9

Which type of ALL occurs primarily in the pediatric age group?

Accepted Answer

A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above 
A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above

Question 10

The FAB classification system separates acute lymphoblastic leukemia into __________ morphologic groups.

Accepted Answer

A)  One 
B)  Two 
C)  Three 
D)  Four 
E)  None of the above 
A)  One 
B)  Two 
C)  Three 
D)  Four 
E)  None of the above

Question 11

Which FAB classification of ALL represents a heterogeneous population and is morphologically similar to AML, type M1?

Accepted Answer

A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above 
A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above

Question 12

Cell morphology is evaluated on a Romanowsky (Wright-Giemsa)-stained blood or bone marrow smear in a carefully chosen area in which cells are:

Accepted Answer

A)  Overcrowded 
B)  Distorted 
C)  Swelled 
D)  Evenly distributed 
E)  None of the above 
A)  Overcrowded 
B)  Distorted 
C)  Swelled 
D)  Evenly distributed 
E)  None of the above

Question 13

Acute monocytic leukemia (M5a) is characterized by the presence of:

Accepted Answer

A)  Promonocytes 
B)  Monocytes 
C)  Monoblasts 
D)  Promyelocytes 
E)  None of the above 
A)  Promonocytes 
B)  Monocytes 
C)  Monoblasts 
D)  Promyelocytes 
E)  None of the above

Question 14

Five percent to 10% of cases of acute myeloblastic leukemia (AML) are preceded by a recognizable "preleukemic" __________ syndrome.

Accepted Answer

A)  Myelodysplastic 
B)  Thalassemia 
C)  Aplastic 
D)  Microangiopathic 
E)  None of the above 
A)  Myelodysplastic 
B)  Thalassemia 
C)  Aplastic 
D)  Microangiopathic 
E)  None of the above

Question 15

The FAB classification system separates acute myeloblastic leukemia into __________ morphologic groups.

Accepted Answer

A)  Three 
B)  Six 
C)  Five 
D)  Seven 
E)  None of the above 
A)  Three 
B)  Six 
C)  Five 
D)  Seven 
E)  None of the above

Question 16

Cases of pure __________ ALL have the best prognosis.

Accepted Answer

A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above 
A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above

Question 17

Leukemia cells are frequently present in the peripheral blood and commonly invade the reticuloendothelial tissue which includes the __________.

Accepted Answer

A)  Spleen 
B)  Liver 
C)  Lymph nodes 
D)  All of the above 
E)  None of the above 
A)  Spleen 
B)  Liver 
C)  Lymph nodes 
D)  All of the above 
E)  None of the above

Question 18

What percentage of blasts is recommended by the French-American-British (FAB) classification system for a diagnosis of acute leukemia?

Accepted Answer

A)  30% 
B)  50% 
C)  20% 
D)  10% 
E)  None of the above 
A)  30% 
B)  50% 
C)  20% 
D)  10% 
E)  None of the above

Question 19

Most precursor B-cell leukemias express CALLA (common ALL antigen) (CD10) on the surface and are therefore referred to as __________ ALL.

Accepted Answer

A)  B-cell 
B)  Common 
C)  Pre-B cell 
D)  CD10 
E)  None of the above 
A)  B-cell 
B)  Common 
C)  Pre-B cell 
D)  CD10 
E)  None of the above

Question 20

A positive nonspecific esterase stain indicates __________ differentiation.

Accepted Answer

A)  Megakaryocytoid 
B)  Monocytic 
C)  Lymphoid 
D)  Plasmacytoid 
E)  Erythrocytic 
A)  Megakaryocytoid 
B)  Monocytic 
C)  Lymphoid 
D)  Plasmacytoid 
E)  Erythrocytic

Exam 16: Introduction to Leukemia and the Acute Leukemias

The cytochemical reactions are performed by applying staining techniques to __________ smears.

A 14-year-old male presents with a mediastinal mass, a WBC of 110  109/L, hepatosplenomegaly, and early central nervous system involvement. Both L1 and L2 morphology are seen, and surface markers CD7, CD2, and CD5 are expressed. Which type of ALL is present?

Which host factor(s) is/are associated with an increased risk of developing leukemia?

A strong PAS reaction supports the diagnosis of __________.

Cell __________ is used to distinguish between acute and chronic forms of leukemia.

The presence of Auer rods in the cytoplasm of cells rules out __________.

Anemia in acute leukemia is generally __________.

Which percentage of blasts does the WHO classification system recommend for a diagnosis of acute leukemia?

Which type of ALL occurs primarily in the pediatric age group?

The FAB classification system separates acute lymphoblastic leukemia into __________ morphologic groups.

Which FAB classification of ALL represents a heterogeneous population and is morphologically similar to AML, type M1?

Cell morphology is evaluated on a Romanowsky (Wright-Giemsa)-stained blood or bone marrow smear in a carefully chosen area in which cells are:

Acute monocytic leukemia (M5a) is characterized by the presence of:

Five percent to 10% of cases of acute myeloblastic leukemia (AML) are preceded by a recognizable "preleukemic" __________ syndrome.

The FAB classification system separates acute myeloblastic leukemia into __________ morphologic groups.

Cases of pure __________ ALL have the best prognosis.

Leukemia cells are frequently present in the peripheral blood and commonly invade the reticuloendothelial tissue which includes the __________.

What percentage of blasts is recommended by the French-American-British (FAB) classification system for a diagnosis of acute leukemia?

Most precursor B-cell leukemias express CALLA (common ALL antigen) (CD10) on the surface and are therefore referred to as __________ ALL.

A positive nonspecific esterase stain indicates __________ differentiation.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

A 14-year-old male presents with a mediastinal mass, a WBC of 110  10⁹/L, hepatosplenomegaly, and early central nervous system involvement. Both L1 and L2 morphology are seen, and surface markers CD7, CD2, and CD5 are expressed. Which type of ALL is present?