Question 1

What other hematologic condition would present a similar peripheral blood picture as megaloblastic anemia?

Accepted Answer

A)  Hemoglobinopathies 
B)  Myelodysplastic syndromes 
C)  Chronic leukemia 
D)  Anemia of chronic disorders 
E)  None of the above 
A)  Hemoglobinopathies 
B)  Myelodysplastic syndromes 
C)  Chronic leukemia 
D)  Anemia of chronic disorders 
E)  None of the above

Question 2

Which of the following is not a cause of vitamin B12 deficiency?

Accepted Answer

A)  Gastrectomy 
B)  Blind loop syndrome 
C)  Blood loss 
D)  Fish tapeworm (Diphyllobothrium latum) 
E)  Diseases of the ileum 
A)  Gastrectomy 
B)  Blind loop syndrome 
C)  Blood loss 
D)  Fish tapeworm (Diphyllobothrium latum) 
E)  Diseases of the ileum

Question 3

What protein is responsible for vitamin B12 transport to the bone marrow?

Accepted Answer

A)  Transcobalamin II 
B)  Intrinsic factor 
C)  Interleukin-3 
D)  Thymidine triphosphate 
E)  None of the above 
A)  Transcobalamin II 
B)  Intrinsic factor 
C)  Interleukin-3 
D)  Thymidine triphosphate 
E)  None of the above

Question 4

Which of the following can lead to a folic acid deficiency?

Accepted Answer

A)  Malabsorption 
B)  Poor diet 
C)  Hemolytic anemia 
D)  All of the above 
E)  None of the above 
A)  Malabsorption 
B)  Poor diet 
C)  Hemolytic anemia 
D)  All of the above 
E)  None of the above

Question 5

What protein is responsible for vitamin B12 absorption?

Accepted Answer

A)  Transcobalamin 
B)  Interleukin-3 
C)  Intrinsic factor 
D)  Erythropoietin 
E)  None of the above 
A)  Transcobalamin 
B)  Interleukin-3 
C)  Intrinsic factor 
D)  Erythropoietin 
E)  None of the above

Question 6

An elderly white male of Scandinavian descent presents with the following hematopoietic studies: MCV = 115 fL, 3+ oval macrocytes, 20% hypersegmented neutrophils. What hematologic condition is suspected?

Accepted Answer

A)  Iron-deficiency anemia 
B)  Megaloblastic anemia 
C)  Thalassemia 
D)  Anemia of chronic disorders 
E)  None of the above 
A)  Iron-deficiency anemia 
B)  Megaloblastic anemia 
C)  Thalassemia 
D)  Anemia of chronic disorders 
E)  None of the above

Question 7

What is the leading cause of anemia in an alcoholic?

Accepted Answer

A)  Vitamin B12 deficiency 
B)  Iron deficiency 
C)  Folate deficiency 
D)  Uridine triphosphate deficiency 
E)  None of the above 
A)  Vitamin B12 deficiency 
B)  Iron deficiency 
C)  Folate deficiency 
D)  Uridine triphosphate deficiency 
E)  None of the above

Question 8

A lack of intrinsic factor is diagnostic for which of the following?

Accepted Answer

A)  Vitamin B12 deficiency 
B)  Folate deficiency 
C)  Pernicious anemia 
D)  All of the above 
E)  None of the above 
A)  Vitamin B12 deficiency 
B)  Folate deficiency 
C)  Pernicious anemia 
D)  All of the above 
E)  None of the above

Question 9

A patient with pernicious anemia has the following indices: mean corpuscular volume (MCV) >100 fL, mean corpuscular hemoglobin (MCH) = 31 pg, mean corpuscular hemoglobin concentration (MCHC) = 33% What might be seen on the peripheral smear?

Accepted Answer

A)  Codocytes 
B)  Macrocytes 
C)  Microcytes 
D)  Schistocytes 
E)  None of the above 
A)  Codocytes 
B)  Macrocytes 
C)  Microcytes 
D)  Schistocytes 
E)  None of the above

Exam 7: Megaloblastic Anemias

What other hematologic condition would present a similar peripheral blood picture as megaloblastic anemia?

Which of the following is not a cause of vitamin B12 deficiency?

What protein is responsible for vitamin B12 transport to the bone marrow?

Which of the following can lead to a folic acid deficiency?

What protein is responsible for vitamin B12 absorption?

An elderly white male of Scandinavian descent presents with the following hematopoietic studies: MCV = 115 fL, 3+ oval macrocytes, 20% hypersegmented neutrophils. What hematologic condition is suspected?

What is the leading cause of anemia in an alcoholic?

A lack of intrinsic factor is diagnostic for which of the following?

A patient with pernicious anemia has the following indices: mean corpuscular volume (MCV) >100 fL, mean corpuscular hemoglobin (MCH) = 31 pg, mean corpuscular hemoglobin concentration (MCHC) = 33% What might be seen on the peripheral smear?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Which of the following is not a cause of vitamin B₁₂deficiency?

What protein is responsible for vitamin B₁₂ transport to the bone marrow?

What protein is responsible for vitamin B₁₂ absorption?