Question 1

The purpose of the acid catalyst in the hydrolysis of an amide is:

Accepted Answer

A) to enhance the nucleophilicity of the water molecule 
B) to enhance the electrophilicity of the amide carbonyl carbon 
C) to enhance the electrophilicity of the water molecule 
D) to shift the equilibrium of the reaction 
A) to enhance the nucleophilicity of the water molecule 
B) to enhance the electrophilicity of the amide carbonyl carbon 
C) to enhance the electrophilicity of the water molecule 
D) to shift the equilibrium of the reaction

Question 2

Ethyl phenylacetate is a pleasant smelling compound used in perfumery.Draw structures for each of the intermediates in the synthesis of ethyl phenylacetate below.

Accepted Answer

The answer of Ethyl phenylacetate is a pleasant smelling compound...

Question 3

Exhibit 21-3
Consider the reaction below to answer the following question(s):  
-Refer to Exhibit 21-3.This reaction is an example of:

Accepted Answer

A) an intermolecular nucleophilic acyl substitution reaction 
B) an intramolecular nucleophilic acyl substitution reaction 
C) an intermolecular SN2 reaction 
D) an intramolecular SN2 reaction 
A) an intermolecular nucleophilic acyl substitution reaction 
B) an intramolecular nucleophilic acyl substitution reaction 
C) an intermolecular SN2 reaction 
D) an intramolecular SN2 reaction

Question 4

Write the complete stepwise mechanism for the acid-catalyzed hydrolysis of the following amide to yield mandelic acid.Show all electron flow with arrows and draw the structures of all intermediate species.

Accepted Answer

The answer of Write the complete stepwise mechanism for the...

Exam 21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

The purpose of the acid catalyst in the hydrolysis of an amide is:

Ethyl phenylacetate is a pleasant smelling compound used in perfumery.Draw structures for each of the intermediates in the synthesis of ethyl phenylacetate below.

Exhibit 21-3 Consider the reaction below to answer the following question(s): -Refer to Exhibit 21-3.This reaction is an example of:

Write the complete stepwise mechanism for the acid-catalyzed hydrolysis of the following amide to yield mandelic acid.Show all electron flow with arrows and draw the structures of all intermediate species.

Structure and Bonding

Polar Covalent Bonds;acids and Bases

Organic Compounds: Alkanes and Their Stereochemistry

Organic Compounds: Cycloalkanes and Their Stereochemistry

Stereochemistry at Tetrahedral Centers

An Overview of Organic Reactions

Par 1

Alkenes: Structure and Reactivity

Alkenes: Reactions and Synthesis

Alkynes: an Introduction to Organic Synthesis

Organohalides

Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations

Par 2

Structure Determination: Mass Spectrometry and Infrared Spectroscopy

Structure Determination: Nuclear Magnetic Resonance Spectroscopy

Conjugated Compounds and Ultraviolet Spectroscopy

Par 3

Benzene and Aromaticity

Chemistry of Benzene: Electrophilic Aromatic Substitution

Alcohols and Phenols

Ethers and Epoxides;thiols and Sulfides

Aldehydes and Ketones: Nucleophilic Addition Reactions

Par 4

Carboxylic Acids and Nitriles

Carbonyl Alpha-Substitution Reactions

Carbonyl Condensation Reactions

Par 5

Amines and Heterocycles

Biomolecules: Carbohydrates

Biomolecules: Amino Acids,peptides,and Proteins

Par 7

Biomolecules: Lipids

Biomolecules: Nucleic Acids

The Organic Chemistry of Metabolic Pathways

Orbitals and Organic Chemistry: Pericyclic Reactions

Synthetic Polymers

Par 1

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