Exam 5: Sex Determination and Sex Chromosomes

Give the sex of the following organisms assuming that the autosomes are present in the normal number. Sex Chromosome Organism Complement Humans Drosophila XX --- --- XY --- --- XO --- --- XXX --- --- XXY --- ---

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Question 1

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$\begin{array}{cll}\text { Sex Chromosome } & &\text { Organism } \\\text { Complement } & \text { Humans } & \text { Drosophila } \\\hline \text { XX } & \text { female } & \text { female } \\\text { XY } & \text { male } & \text { male } \\\text { XO } & \text { female } & \text { male } \\\text { XXX } & \text { female } & \text { female } \\\text { XXY } & \text { male } & \text { female }\end{array}$

Below is a pedigree of a fairly common human hereditary trait; the boxes represent males and the circles represent females.Filled-in symbols indicate the abnormal phenotype.Given that one gene pair is involved, (a)Is the inheritance pattern X-linked or autosomal? (b)Give the genotype of each individual in the pedigree.If more than one genotypic possibility exists,present all possible alternatives.

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(a)autosomal recessive
(b)

How many Barr bodies would one expect to see in cells of Turner syndrome females and Klinefelter syndrome males?

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Question 3

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zero and one,respectively

One form of hemophilia is caused by a sex-linked recessive gene.Assume that a man with hemophilia marries a phenotypically normal woman whose father had hemophilia.What is the probability that they will have a daughter with hemophilia? (Note: In this problem,you must include the probability of having a daughter in your computation of the final probability.)

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Question 4

What particular karyotype was once considered to be related to criminal predisposition?

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Question 5

Give the sex-chromosome constitution (X and Y chromosomes)and possible genotypes of offspring resulting from a cross between a white-eyed female (X^w X^wY)and a wild-type male (normal chromosome complement)in Drosophila melanogaster.Include all zygotic combinations whether viable or unviable.

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Question 6

Studies done in the 1960s suggested that individuals with the XYY condition were prone to criminal behavior.What conclusions currently seem appropriate concerning this chromosomal condition?

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Question 7

Normally in humans,all the sons of a male showing a sex-linked phenotype will inherit the trait.

(True/False)

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Question 8

In Drosophila,the female is the heterogametic sex.

(True/False)

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Question 9

A cross is made between a female calico cat and a male cat having the gene for black fur on his X chromosome.What fraction of the offspring would one expect to be calico?

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Question 10

In humans,the genetic basis for determining the sex "male" is accomplished by the presence of ________.

(Multiple Choice)

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Question 11

Data produced by C.Bridges in the early part of this century indicate that sex in Drosophila is determined by ________.

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Question 12

Describe an experiment in which transgenic mice were used to identify the male-determining region of the Y chromosome.

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Question 13

A color-blind woman with Turner syndrome (XO)has a father who is color-blind.Given that the gene for the color-blind condition is recessive and X-linked,provide a likely explanation for the origin of the color-blind and cytogenetic conditions in the woman.

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Question 14

What is the composition of a Barr body?

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Question 15

How many chromosomes do Klinefelter and Turner syndromes have,respectively?

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Question 16

An individual with Klinefelter syndrome generally has one Barr body.

(True/False)

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Question 17

An individual with Turner syndrome has no Barr bodies.

(True/False)

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Question 18

Klinefelter syndrome in humans,which leads to underdeveloped testes and sterility,is caused by which chromosomal condition?

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Question 19

Glucose-6-phosphate dehydrogenase (G6PD)deficiency is inherited as an X-linked recessive gene in humans.A woman whose father suffered from G6PD marries a normal man. (a)What proportion of their sons is expected to be G6PD? (b)If the husband were not normal but were G6PD deficient,would you change your answer in part (a)?

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Question 20

Give the sex of the following organisms assuming that the autosomes are present in the normal number. Sex Chromosome Organism Complement Humans Drosophila XX --- --- XY --- --- XO --- --- XXX --- --- XXY --- ---

How many Barr bodies would one expect to see in cells of Turner syndrome females and Klinefelter syndrome males?

What particular karyotype was once considered to be related to criminal predisposition?

Give the sex-chromosome constitution (X and Y chromosomes)and possible genotypes of offspring resulting from a cross between a white-eyed female (X^w X^wY)and a wild-type male (normal chromosome complement)in Drosophila melanogaster.Include all zygotic combinations whether viable or unviable.

Studies done in the 1960s suggested that individuals with the XYY condition were prone to criminal behavior.What conclusions currently seem appropriate concerning this chromosomal condition?

Normally in humans,all the sons of a male showing a sex-linked phenotype will inherit the trait.

In Drosophila,the female is the heterogametic sex.

A cross is made between a female calico cat and a male cat having the gene for black fur on his X chromosome.What fraction of the offspring would one expect to be calico?

In humans,the genetic basis for determining the sex "male" is accomplished by the presence of ________.

Data produced by C.Bridges in the early part of this century indicate that sex in Drosophila is determined by ________.

Describe an experiment in which transgenic mice were used to identify the male-determining region of the Y chromosome.

A color-blind woman with Turner syndrome (XO)has a father who is color-blind.Given that the gene for the color-blind condition is recessive and X-linked,provide a likely explanation for the origin of the color-blind and cytogenetic conditions in the woman.

What is the composition of a Barr body?

How many chromosomes do Klinefelter and Turner syndromes have,respectively?

An individual with Klinefelter syndrome generally has one Barr body.

An individual with Turner syndrome has no Barr bodies.

Klinefelter syndrome in humans,which leads to underdeveloped testes and sterility,is caused by which chromosomal condition?

Introduction to Genetics

Mitosis and Meiosis

Mendelian Genetics

Modification of Mendelian Ratios

Chromosome Mutations: Variation in Number and Arrangement

Linkage and Chromosome Mapping in Eukaryotes

Genetic Analysis and Mapping in Bacteria and Bacteriophages

DNA structure and Analysis

DNA Replication and Recombination

Chromosome Structure and DNA Sequence Organization

The Genetic Code and Transcription

Translation and Proteins

Gene Mutation,DNA Repair,and Transposition

Regulation of Gene Expression

The Genetics of Cancer

Recombinant DNA Technology

Genomics,Bioinformatics,and Proteomics

Applications and Ethics of Genetic Engineering and Biotechnology

Developmental Genetics

Quantitative Genetics and Multifactorial Traits

Population and Evolutionary Genetics

Conservation Genetics

Filters

Exam 5: Sex Determination and Sex Chromosomes

Give the sex of the following organisms assuming that the autosomes are present in the normal number. Sex Chromosome Organism Complement Humans Drosophila XX --- --- XY --- --- XO --- --- XXX --- --- XXY --- ---

How many Barr bodies would one expect to see in cells of Turner syndrome females and Klinefelter syndrome males?

What particular karyotype was once considered to be related to criminal predisposition?

Give the sex-chromosome constitution (X and Y chromosomes)and possible genotypes of offspring resulting from a cross between a white-eyed female (Xw XwY)and a wild-type male (normal chromosome complement)in Drosophila melanogaster.Include all zygotic combinations whether viable or unviable.

Studies done in the 1960s suggested that individuals with the XYY condition were prone to criminal behavior.What conclusions currently seem appropriate concerning this chromosomal condition?

Normally in humans,all the sons of a male showing a sex-linked phenotype will inherit the trait.

In Drosophila,the female is the heterogametic sex.

A cross is made between a female calico cat and a male cat having the gene for black fur on his X chromosome.What fraction of the offspring would one expect to be calico?

In humans,the genetic basis for determining the sex "male" is accomplished by the presence of ________.

Data produced by C.Bridges in the early part of this century indicate that sex in Drosophila is determined by ________.

Describe an experiment in which transgenic mice were used to identify the male-determining region of the Y chromosome.

A color-blind woman with Turner syndrome (XO)has a father who is color-blind.Given that the gene for the color-blind condition is recessive and X-linked,provide a likely explanation for the origin of the color-blind and cytogenetic conditions in the woman.

What is the composition of a Barr body?

How many chromosomes do Klinefelter and Turner syndromes have,respectively?

An individual with Klinefelter syndrome generally has one Barr body.

An individual with Turner syndrome has no Barr bodies.

Klinefelter syndrome in humans,which leads to underdeveloped testes and sterility,is caused by which chromosomal condition?

Introduction to Genetics

Mitosis and Meiosis

Mendelian Genetics

Modification of Mendelian Ratios

Chromosome Mutations: Variation in Number and Arrangement

Linkage and Chromosome Mapping in Eukaryotes

Genetic Analysis and Mapping in Bacteria and Bacteriophages

DNA structure and Analysis

DNA Replication and Recombination

Chromosome Structure and DNA Sequence Organization

The Genetic Code and Transcription

Translation and Proteins

Gene Mutation,DNA Repair,and Transposition

Regulation of Gene Expression

The Genetics of Cancer

Recombinant DNA Technology

Genomics,Bioinformatics,and Proteomics

Applications and Ethics of Genetic Engineering and Biotechnology

Developmental Genetics

Quantitative Genetics and Multifactorial Traits

Population and Evolutionary Genetics

Conservation Genetics

Filters

Give the sex-chromosome constitution (X and Y chromosomes)and possible genotypes of offspring resulting from a cross between a white-eyed female (X^w X^wY)and a wild-type male (normal chromosome complement)in Drosophila melanogaster.Include all zygotic combinations whether viable or unviable.