Exam 18: Genomics,Bioinformatics,and Proteomics

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The Human Genome Project,which got underway in 1990,is an international effort to ________.

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Sequencing the dog genome has indicated that a single locus on chromosome 15 may play a major role in genetically distinguishing large dog breeds from small dog breeds.

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The Human Genome Project is an international effort to construct a physical map sequence of the approximately 3 billion base pairs in the haploid human genome.

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What is meant by the term low gene density? Give an example of an organism with low gene density.

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The term paralog is often used in conjunction with discussions of hemoglobin genes.What does this term mean,and how does it apply to hemoglobin genes?

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Which two factors contribute significantly to the wide ranges of genome size among eukaryotes?

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The dog (Canis familiaris)genome has recently been sequenced.About how many of the dog's genes are shared with humans?

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Introns are found only in prokaryotic genomes.

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What is ELSI?

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Numerous scientists around the world have proposed to sequence 10,000 vertebrate genomes in five years.What is the name of this plan?

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Multigene families are characterized by clusters of tandemly arranged unique pseudogenes organized as operons.

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The human genome contains approximately 20,000 protein-coding genes,yet it has the capacity to produce several hundred thousand gene products.What can account for the vast difference in gene number and product number?

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The genomic organization of all living creatures is identical.

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Most of the bacterial genomes described in the text have fewer than ________.

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There is a general inverse relationship between DNA content and organismic complexity.

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Name the two strategic methods that scientists are using to sequence genomes.

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What is meant by the term pseudogene?

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Bacterial genes have introns,and eukaryotic genes lack introns.

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Archaea (formerly known as archaebacteria)is one of the three major divisions of living organisms; the other two are eubacteria and eukaryotes.Nanoarchaeum equitans is in the Archaea domain and has one of the smallest genomes known,about 0.5 Mb.How can an organism complete its life cycle with so little genetic material?

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Intron frequency varies considerably among eukaryotes.Provide a general comparison of intron frequencies in yeast and humans.What about intron size?

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