Question 1

Which of the following are actions of p53? (Select all correct choices)

Accepted Answer

A) The p53 protein can bind to several members of the Bcl-2 family proteins in a manner that stimulates apoptosis. 
B) The p53 protein can bind to Bax proteins at the outer mitochondrial membrane, directly triggering membrane permeabilization and release of apoptotic factors. 
C) The p53 protein can bind to several members of the Bcl-2 family proteins in a manner that stimulates meiosis. 
D) The p53 protein can bind to DNA and proofread it for errors. 
A) The p53 protein can bind to several members of the Bcl-2 family proteins in a manner that stimulates apoptosis. 
B) The p53 protein can bind to Bax proteins at the outer mitochondrial membrane, directly triggering membrane permeabilization and release of apoptotic factors. 
C) The p53 protein can bind to several members of the Bcl-2 family proteins in a manner that stimulates meiosis. 
D) The p53 protein can bind to DNA and proofread it for errors. A, B

Question 2

A single layer of cells that covers a culture dish is called _________.

Accepted Answer

A) a permalayer 
B) an imperium 
C) a monolayer 
D) a unilayer 
A) a permalayer 
B) an imperium 
C) a monolayer 
D) a unilayer C

Question 3

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes?

Accepted Answer

A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase 
A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase B

Question 4

What generally happens if cells that have been transformed into cancer cells in culture by carcinogenic chemicals or viruses are introduced into a host animal?

Accepted Answer

A) Nothing happens; they do not survive the introduction process. 
B) They are reconverted to normal cells in the host. 
C) They generally cause tumors in the host animal. 
D) The host animal's immune system destroys the transformed cancer cells. 
A) Nothing happens; they do not survive the introduction process. 
B) They are reconverted to normal cells in the host. 
C) They generally cause tumors in the host animal. 
D) The host animal's immune system destroys the transformed cancer cells.

Question 5

The cancer vaccine Provenge utilizes which type of cells from the patient?

Accepted Answer

A) erythrocytes 
B) fibroblasts 
C) Schwann cells 
D) white blood cells 
E) prostate cells 
A) erythrocytes 
B) fibroblasts 
C) Schwann cells 
D) white blood cells 
E) prostate cells

Question 6

If any of the proteins involved in mismatch repair are damaged, the mutation rate and cancer risk will rise; this is called the ___________.

Accepted Answer

A) stability phenotype 
B) mutator phenotype 
C) mutator genotype 
D) alteration phenotype 
E) alteration genotype 
A) stability phenotype 
B) mutator phenotype 
C) mutator genotype 
D) alteration phenotype 
E) alteration genotype

Question 7

What effect does the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus have on the cells infected with the virus?

Accepted Answer

A) The infected cells stop growing. 
B) The infected cells proliferate in an uncontrolled manner. 
C) The infected cells undergo apoptosis. 
D) The infected cells hyperdifferentiate. 
A) The infected cells stop growing. 
B) The infected cells proliferate in an uncontrolled manner. 
C) The infected cells undergo apoptosis. 
D) The infected cells hyperdifferentiate.

Question 8

What evidence suggests that while viruses may play a role in cancer development and increase a person's risk of developing cancer, they are rarely the sole determinant responsible for the disease?

Accepted Answer

A) Human papilloma virus (HPV)is transmitted by sexual intercourse. 
B) Although HPV is found in ~90% of human cervical cancers, most women infected with the virus never develop the cancer. 
C) HPV is found in ~90% of human cervical cancers, and women infected with the virus develop the cancer. 
D) All women infected with HPV develop cervical cancer. 
A) Human papilloma virus (HPV)is transmitted by sexual intercourse. 
B) Although HPV is found in ~90% of human cervical cancers, most women infected with the virus never develop the cancer. 
C) HPV is found in ~90% of human cervical cancers, and women infected with the virus develop the cancer. 
D) All women infected with HPV develop cervical cancer.

Question 9

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

Accepted Answer

A) Active immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Passive immunotherapy 
A) Active immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Passive immunotherapy

Question 10

About 25% of breast cancers are composed of cells that overexpress the HER2 gene. What property does the overexpression of this gene confer upon the tumor cells?

Accepted Answer

A) The tumor cells are more responsive to Herceptin stimulation in the body. 
B) The tumor cells are less responsive to Herceptin stimulation. 
C) The tumor cells are more likely to undergo apoptosis. 
D) These cells are especially sensitive to growth factor stimulation. 
E) These cells are especially resistant to growth factor stimulation. 
A) The tumor cells are more responsive to Herceptin stimulation in the body. 
B) The tumor cells are less responsive to Herceptin stimulation. 
C) The tumor cells are more likely to undergo apoptosis. 
D) These cells are especially sensitive to growth factor stimulation. 
E) These cells are especially resistant to growth factor stimulation.

Question 11

What is a "humanized" monoclonal antibody, as used in passive immunotherapy?

Accepted Answer

A) An antibody that is derived from mouse lymphocytes and used in human cancer therapy 
B) A human antibody that is produced by one cancer patient and administered to another 
C) A mouse-produced engineered antibody with an antigen recognition surface of mouse origin 
D) An antibody that is introduced for expression in humans by human researchers 
E) An antibody against a tumor antigen that is produced by healthy people 
A) An antibody that is derived from mouse lymphocytes and used in human cancer therapy 
B) A human antibody that is produced by one cancer patient and administered to another 
C) A mouse-produced engineered antibody with an antigen recognition surface of mouse origin 
D) An antibody that is introduced for expression in humans by human researchers 
E) An antibody against a tumor antigen that is produced by healthy people

Question 12

If patients with advanced chronic myelogenous leukemia were initially treated with Gleevec, they eventually develop resistance to the drug. What seems to cause the resistance?

Accepted Answer

A) mutations in the BCR portion of the fusion gene 
B) mutations in the ABL portion of the fusion gene 
C) ABL gene deletion 
D) ABL gene amplification 
E) BCR gene amplification 
A) mutations in the BCR portion of the fusion gene 
B) mutations in the ABL portion of the fusion gene 
C) ABL gene deletion 
D) ABL gene amplification 
E) BCR gene amplification

Question 13

Twenty-first century drug research using computational methods hopes to identify new medications from which of the following sources?

Accepted Answer

A) plants 
B) fungi 
C) bacteria 
D) all are correct choices 
A) plants 
B) fungi 
C) bacteria 
D) all are correct choices

Question 14

Oncogenes are __________.

Accepted Answer

A) eukaryotic cellular genes that were incorporated into the viral genome during a previous infection 
B) genes that originated in bacterial genomes 
C) genes that originated in viral genomes but are found in eukaryotic genomes 
D) genes that originated in bacterial genomes, moved to viral genomes and were eventually transferred to eukaryotes 
A) eukaryotic cellular genes that were incorporated into the viral genome during a previous infection 
B) genes that originated in bacterial genomes 
C) genes that originated in viral genomes but are found in eukaryotic genomes 
D) genes that originated in bacterial genomes, moved to viral genomes and were eventually transferred to eukaryotes

Question 15

How does the behavior of the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Accepted Answer

A) The altered receptor behaves in the same way as the wild-type receptor. 
B) The altered receptor constitutively stimulates cell growth in the presence and absence of the growth factor. 
C) The altered receptor stimulates cell growth in the presence of the growth factor, but not in its absence. 
D) The altered receptor constitutively represses growth and cell proliferation in the presence and absence of the growth factor. 
E) The altered receptor stimulates cell growth in the absence of the growth factor, but not in its presence. 
A) The altered receptor behaves in the same way as the wild-type receptor. 
B) The altered receptor constitutively stimulates cell growth in the presence and absence of the growth factor. 
C) The altered receptor stimulates cell growth in the presence of the growth factor, but not in its absence. 
D) The altered receptor constitutively represses growth and cell proliferation in the presence and absence of the growth factor. 
E) The altered receptor stimulates cell growth in the absence of the growth factor, but not in its presence.

Question 16

Lacking any functional TP53 gene __________. (Select all correct choices)

Accepted Answer

A) causes a cell carrying damaged DNA to be destroyed 
B) causes a cell carrying damaged DNA to fail to be destroyed 
C) will allow genetically unstable cells to continue to divide 
D) will stop genetically unstable cells from dividing 
A) causes a cell carrying damaged DNA to be destroyed 
B) causes a cell carrying damaged DNA to fail to be destroyed 
C) will allow genetically unstable cells to continue to divide 
D) will stop genetically unstable cells from dividing

Question 17

What part of the cell cycle does the pRB protein help to regulate?

Accepted Answer

A) S to G2 transition 
B) G1 to S transition 
C) G2 to M transition 
D) G0 to G1 transition 
E) M to G2 transition 
A) S to G2 transition 
B) G1 to S transition 
C) G2 to M transition 
D) G0 to G1 transition 
E) M to G2 transition

Question 18

Which type of new screening test will be able to identify cancers based on the relative levels of various proteins in the blood?

Accepted Answer

A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) epinomics 
A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) epinomics

Question 19

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

Accepted Answer

A) Familial adenomatous polyposis coli 
B) Familial hypercholesterolemia 
C) Inherited adenomitis 
D) Familial polypsoidemia 
E) Inherited polypoma intestines 
A) Familial adenomatous polyposis coli 
B) Familial hypercholesterolemia 
C) Inherited adenomitis 
D) Familial polypsoidemia 
E) Inherited polypoma intestines

Question 20

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to be a common occurence. What is presently thought to be the best drug regimen for treating chronic myelogenous leukemia?

Accepted Answer

A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins 
A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins

Which of the following are actions of p53? (Select all correct choices)

A single layer of cells that covers a culture dish is called _________.

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes?

What generally happens if cells that have been transformed into cancer cells in culture by carcinogenic chemicals or viruses are introduced into a host animal?

The cancer vaccine Provenge utilizes which type of cells from the patient?

If any of the proteins involved in mismatch repair are damaged, the mutation rate and cancer risk will rise; this is called the ___________.

What effect does the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus have on the cells infected with the virus?

What evidence suggests that while viruses may play a role in cancer development and increase a person's risk of developing cancer, they are rarely the sole determinant responsible for the disease?

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

About 25% of breast cancers are composed of cells that overexpress the HER2 gene. What property does the overexpression of this gene confer upon the tumor cells?

What is a "humanized" monoclonal antibody, as used in passive immunotherapy?

If patients with advanced chronic myelogenous leukemia were initially treated with Gleevec, they eventually develop resistance to the drug. What seems to cause the resistance?

Twenty-first century drug research using computational methods hopes to identify new medications from which of the following sources?

Oncogenes are __________.

How does the behavior of the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Lacking any functional TP53 gene __________. (Select all correct choices)

What part of the cell cycle does the pRB protein help to regulate?

Which type of new screening test will be able to identify cancers based on the relative levels of various proteins in the blood?

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to be a common occurence. What is presently thought to be the best drug regimen for treating chronic myelogenous leukemia?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

Which of the following are actions of p53? (Select all correct choices)

A single layer of cells that covers a culture dish is called _________.

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes?

What generally happens if cells that have been transformed into cancer cells in culture by carcinogenic chemicals or viruses are introduced into a host animal?

The cancer vaccine Provenge utilizes which type of cells from the patient?

If any of the proteins involved in mismatch repair are damaged, the mutation rate and cancer risk will rise; this is called the ___________.

What effect does the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus have on the cells infected with the virus?

What evidence suggests that while viruses may play a role in cancer development and increase a person's risk of developing cancer, they are rarely the sole determinant responsible for the disease?

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

About 25% of breast cancers are composed of cells that overexpress the HER2 gene. What property does the overexpression of this gene confer upon the tumor cells?

What is a "humanized" monoclonal antibody, as used in passive immunotherapy?

If patients with advanced chronic myelogenous leukemia were initially treated with Gleevec, they eventually develop resistance to the drug. What seems to cause the resistance?

Twenty-first century drug research using computational methods hopes to identify new medications from which of the following sources?

Oncogenes are __________.

How does the behavior of the altered erbB -encoded receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Lacking any functional TP53 gene __________. (Select all correct choices)

What part of the cell cycle does the pRB protein help to regulate?

Which type of new screening test will be able to identify cancers based on the relative levels of various proteins in the blood?

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to be a common occurence. What is presently thought to be the best drug regimen for treating chronic myelogenous leukemia?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters