Question 1

All of the following autoimmune diseases affect the muscles except _____.

Accepted Answer

A) SLE 
B) dermatomyositis 
C) myasthenia gravis 
D) polymyositis 
A) SLE 
B) dermatomyositis 
C) myasthenia gravis 
D) polymyositis A

Question 2

Which of the following does not need to be disposed of in cytotoxic waste bags?

Accepted Answer

A) Mitoxantrone 
B) Etanercept 
C) Methotrexate 
D) Azathioprine 
A) Mitoxantrone 
B) Etanercept 
C) Methotrexate 
D) Azathioprine B

Question 3

Which class of medication is prescribed commonly to suppress inflammation,reduce flare-ups,and treat pain in autoimmune disorders?

Accepted Answer

A) Antibiotics 
B) Glucocorticoids 
C) Antivirals 
D) Mineralocorticoids 
A) Antibiotics 
B) Glucocorticoids 
C) Antivirals 
D) Mineralocorticoids B

Question 4

MATCHING
Match the following drugs with their drug classes.
-Methylprednisolone

Accepted Answer

A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid 
A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid

Question 5

How does aspirin help relieve the pain associated with MS?

Accepted Answer

A) It inhibits MAO,which reduces anxiety and decreases pain perception. 
B) It blocks purine synthesis,reducing the levels of pain mediators. 
C) It increases streptokinase activity,which helps synthesize prostaglandins,reducing pain. 
D) It blocks cyclooxygenase (COX)enzyme activity,which inhibits pain mediators. 
A) It inhibits MAO,which reduces anxiety and decreases pain perception. 
B) It blocks purine synthesis,reducing the levels of pain mediators. 
C) It increases streptokinase activity,which helps synthesize prostaglandins,reducing pain. 
D) It blocks cyclooxygenase (COX)enzyme activity,which inhibits pain mediators.

Question 6

In myasthenia gravis,the body attacks and destroys receptor sites in the neuromuscular junction that bind _____.

Accepted Answer

A) dopamine (D
A)  
B) norepinephrine (N
E)  
C) acetylcholine (ACh) 
D) g-aminobutyric acid (GAB
A)  
A) dopamine (D
A)  
B) norepinephrine (N
E)  
C) acetylcholine (ACh) 
D) g-aminobutyric acid (GAB
A)

Question 7

Which of the following is not considered an autoimmune disease?

Accepted Answer

A) Myasthenia gravis 
B) Multiple sclerosis (MS) 
C) Osteoarthritis 
D) Systemic lupus erythematosus (SL
E)  
A) Myasthenia gravis 
B) Multiple sclerosis (MS) 
C) Osteoarthritis 
D) Systemic lupus erythematosus (SL
E)

Question 8

Which of the following is genetically engineered to block the inflammatory process triggered by an increased concentration of TNF?

Accepted Answer

A) Anakinra 
B) Cyclosporine 
C) Adalimumab 
D) Methotrexate 
A) Anakinra 
B) Cyclosporine 
C) Adalimumab 
D) Methotrexate

Question 9

_____ is used in the treatment of multiple sclerosis because it effectively decreases the progression of the disease.

Accepted Answer

A) Mitoxantrone 
B) Hydroxychloroquine 
C) Cyclosporine 
D) Betamethasone 
A) Mitoxantrone 
B) Hydroxychloroquine 
C) Cyclosporine 
D) Betamethasone

Question 10

MATCHING
Match the following drugs with their drug classes.
-Cyclosporine

Accepted Answer

A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid 
A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid

Question 11

Immunosuppressive drugs work by _____.

Accepted Answer

A) interfering with the formation of prostaglandin 
B) damaging RNA and DNA needed for replication 
C) forming enzymes to synthesize antigens 
D) reconfiguring the cell duplication process 
A) interfering with the formation of prostaglandin 
B) damaging RNA and DNA needed for replication 
C) forming enzymes to synthesize antigens 
D) reconfiguring the cell duplication process

Question 12

How do glucocorticoids help suppress the immune system?

Accepted Answer

A) They interfere with the formation of immune cells by damaging RNA and DNA needed for cell replication. 
B) They inhibit the synthesis of antibodies that are responsible for attacking the body's healthy cells. 
C) They increase levels of antigens in the body. 
D) They increase leukocytes and T cells. 
A) They interfere with the formation of immune cells by damaging RNA and DNA needed for cell replication. 
B) They inhibit the synthesis of antibodies that are responsible for attacking the body's healthy cells. 
C) They increase levels of antigens in the body. 
D) They increase leukocytes and T cells.

Question 13

Which of the following drugs can be used to treat spasticity in MS?

Accepted Answer

A) Infliximab 
B) Carbamazepine 
C) Baclofen 
D) Amantadine 
A) Infliximab 
B) Carbamazepine 
C) Baclofen 
D) Amantadine

Question 14

Which of the following contains a black box warning for GI ulceration?

Accepted Answer

A) Chloroquine 
B) Prednisone 
C) Naproxen 
D) Acetaminophen 
A) Chloroquine 
B) Prednisone 
C) Naproxen 
D) Acetaminophen

Question 15

Why would methylprednisolone be prescribed as an alternate day therapy?

Accepted Answer

A) To minimize adverse effects 
B) Because of its long half-life 
C) Because elimination is slow 
D) Because it is stored in fat so the body can use it when it needs it 
A) To minimize adverse effects 
B) Because of its long half-life 
C) Because elimination is slow 
D) Because it is stored in fat so the body can use it when it needs it

Question 16

An autoimmune disease occurs when the body _____.

Accepted Answer

A) attacks the cells it is designed to protect 
B) defends its own cells,thinking they are germs or a harmful substance 
C) manufactures cells to replace the ones it attacked 
D) creates substances that damage normal body functions 
A) attacks the cells it is designed to protect 
B) defends its own cells,thinking they are germs or a harmful substance 
C) manufactures cells to replace the ones it attacked 
D) creates substances that damage normal body functions

Question 17

_____ levels are elevated in people that have SLE.

Accepted Answer

A) Antinuclear antibody (AN
A)  
B) Monoamine oxidase (MAO) 
C) Protein specific antigen 
D) Adrenocorticotropic hormone 
A) Antinuclear antibody (AN
A)  
B) Monoamine oxidase (MAO) 
C) Protein specific antigen 
D) Adrenocorticotropic hormone

Question 18

_____ is used to treat muscle weakness in patients with myasthenia gravis.

Accepted Answer

A) Glatiramer 
B) Abatacept 
C) Penicillamine 
D) Neostigmine 
A) Glatiramer 
B) Abatacept 
C) Penicillamine 
D) Neostigmine

Question 19

MATCHING
Match the following drugs with their drug classes.
-Chloroquine

Accepted Answer

A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid 
A) Interleukin antagonist 
B) NSAID 
C) TNF inhibitor 
D) Antimalarial 
E) Immunosuppressive
F)Glucocorticoid

Question 20

Why would glucocorticoids be prescribed to help pain associated with RA?

Accepted Answer

A) They increase the synthesis of proinflammatory substances,which decreases pain. 
B) They inhibit the synthesis of tumor necrosis factor (TNF),which is responsible for pain. 
C) They increase the levels of antinuclear antibodies,reducing inflammation and pain. 
D) They reduce the synthesis of prostaglandins. 
A) They increase the synthesis of proinflammatory substances,which decreases pain. 
B) They inhibit the synthesis of tumor necrosis factor (TNF),which is responsible for pain. 
C) They increase the levels of antinuclear antibodies,reducing inflammation and pain. 
D) They reduce the synthesis of prostaglandins.

Exam 15: Treatment of Autoimmune Diseases That Affect the Musculoskeletal System

All of the following autoimmune diseases affect the muscles except _____.

Which of the following does not need to be disposed of in cytotoxic waste bags?

Which class of medication is prescribed commonly to suppress inflammation,reduce flare-ups,and treat pain in autoimmune disorders?

MATCHING Match the following drugs with their drug classes. -Methylprednisolone

How does aspirin help relieve the pain associated with MS?

In myasthenia gravis,the body attacks and destroys receptor sites in the neuromuscular junction that bind _____.

Which of the following is not considered an autoimmune disease?

Which of the following is genetically engineered to block the inflammatory process triggered by an increased concentration of TNF?

_____ is used in the treatment of multiple sclerosis because it effectively decreases the progression of the disease.

MATCHING Match the following drugs with their drug classes. -Cyclosporine

Immunosuppressive drugs work by _____.

How do glucocorticoids help suppress the immune system?

Which of the following drugs can be used to treat spasticity in MS?

Which of the following contains a black box warning for GI ulceration?

Why would methylprednisolone be prescribed as an alternate day therapy?

An autoimmune disease occurs when the body _____.

_____ levels are elevated in people that have SLE.

_____ is used to treat muscle weakness in patients with myasthenia gravis.

MATCHING Match the following drugs with their drug classes. -Chloroquine

Why would glucocorticoids be prescribed to help pain associated with RA?

Fundamentals of Pharmacology

Principles of Pharmacology

Pharmacodynamics

Drug Interactions and Medication Errors

Treatment of Anxiety

Treatment of Depression

Treatment of Schizophrenia and Psychoses

Treatment of Parkinsons Disease and Huntingtons Disease

Treatment of Seizure Disorders

Treatment of Pain and Migraine Headache

Treatment of Alzheimers Disease

Treatment of Sleep Disorders and Attention-Deficit Hyperactivity Disorder

Neuromuscular Blockade

Treatment of Muscle Spasms

Treatment of Osteoporosis and Pagets Disease of the Bone

Treatment of Hyperuricemia and Gout

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