Exam 2: Selection and Analytical Evaluation of Methodswith Statistical Techniques

To systematically assess errors associated with laboratory results,a parameter associated with the result of a measurement that characterizes the dispersion of the values reasonably attributed to the substance being measured is considered.This parameter is expressed by a formula that includes preanalytical,analytical,and traceability components and is referred to as:

The ability of an analytical method to assess small variations of the concentration of an analyte,and that is often expressed as the slope of the calibration curve,is referred to as:

A list of intervals followed by a list of frequencies is referred to as a:

A statistic is a:

Following a precision study in which repeatability and reproducibility of 20 samples are assessed,which one of the following formulae would be used to determine the total standard deviation ( $\sigma$ ²_T)?

In a chemistry methods analysis,linearity refers to the:

Comparisons of measurement values between clinical laboratories require a hierarchical approach that obliges routine clinical chemistry measurements to be referred back to a reference measurement procedure.This concept is known as:

The Student t distribution:

You are performing a precision study on a new chemistry analyzer in your hospital lab by analyzing a single sample many times.The study involves performing the analysis on different shifts using different calibrators and analysis by different laboratorians.This aspect of precision is referred to as:

The type of method comparison that compares the average results between two analyses with the differences between varying concentration values of the two analyses is referred to as a(n):

Method selection involves consideration of several different criteria.Assessment of a candidate method's precision,accuracy,and analytical specificity are components of which one of the following categories?

In a qualitative point-of-care test,clinical sensitivity is considered as the:

In the calibration hierarchy,a reference measurement procedure,which is a fully understood procedure of highest analytical quality,is at the top.This procedure is associated with which one of the following types of error?

How is the formula for population standard deviation ( $\sigma$ )stated?

A research project examining cholesterol values using a new Cholestcheck assay produces the following cholesterol values from a random sample of 14,25-year-old women: Mean = 137 mg/dL 2 standard deviations = 6 mg/dL N = 14 The coefficient of variation percent for this assay is:

The statistical analysis used to compare values obtained by a new method with those obtained by an established method is:

Which one of the following is the correct formula for calculating the percent coefficient of variation of a set of measurements?

The type of regression analysis that is considered to reliably estimate the relationship between modified target values and that takes into account errors in both methods 1 and 2 is _____ regression analysis.

Two types of error may be encountered during analysis of a substance.The type of error that occurs with a constant or predictable difference or trend,either positive or negative,and thus is related to bias,is a(n)_____ error.

A population mean (µ)is calculated by which one of the following formulae?