Question 1

Cytoplasmic µ, in the immunologic classification of ALL, is expressed in __________ ALL.

Accepted Answer

A)  Common ALL 
B)  T-cell 
C)  Precursor B-cell 
D)  B-cell 
E)  Burkitt's lymphoma 
A)  Common ALL 
B)  T-cell 
C)  Precursor B-cell 
D)  B-cell 
E)  Burkitt's lymphoma

Question 2

Which cytochemical stains show strong positivity in acute monocytic leukemia (M5)?

Accepted Answer

A)  Peroxidase 
B)  Nonspecific esterase 
C)  SBB 
D)  TdT 
E)  None of the above 
A)  Peroxidase 
B)  Nonspecific esterase 
C)  SBB 
D)  TdT 
E)  None of the above

Question 3

Lack of a significant increase in reticulocytes in erythroleukemia is due to:

Accepted Answer

A)  Extramedullary hematopoiesis 
B)  Intramedullary hematopoiesis 
C)  Ineffective erythropoiesis 
D)  Ineffective hematopoiesis 
E)  None of the above 
A)  Extramedullary hematopoiesis 
B)  Intramedullary hematopoiesis 
C)  Ineffective erythropoiesis 
D)  Ineffective hematopoiesis 
E)  None of the above

Question 4

In leukemia, the presence of immature malignant cells is classified as __________.

Accepted Answer

A)  Chronic 
B)  Myeloid 
C)  Acute 
D)  Lymphoid 
E)  Myeloid metaplasia 
A)  Chronic 
B)  Myeloid 
C)  Acute 
D)  Lymphoid 
E)  Myeloid metaplasia

Question 5

What is the ratio of development of leukemia in adults versus children?

Accepted Answer

A)  5:1 
B)  10:1 
C)  1:10 
D)  1:5 
E)  None of the above 
A)  5:1 
B)  10:1 
C)  1:10 
D)  1:5 
E)  None of the above

Question 6

Which cytochemical stain is used to detect acute megakaryoblastic leukemia (M7)?

Accepted Answer

A)  Myeloperoxidase 
B)  SBB 
C)  Platelet peroxidase 
D)  TdT 
E)  None of the above 
A)  Myeloperoxidase 
B)  SBB 
C)  Platelet peroxidase 
D)  TdT 
E)  None of the above

Question 7

Which of the following cytochemical stains differentiates AML from ALL?

Accepted Answer

A)  Myeloperoxidase 
B)  PAS 
C)  Nonspecific esterase 
D)  All of the above 
E)  None of the above 
A)  Myeloperoxidase 
B)  PAS 
C)  Nonspecific esterase 
D)  All of the above 
E)  None of the above

Question 8

A 5-year-old girl presents with anemia, neutropenia, thrombocytopenia, lymphoblasts, and prolymphocytes. Cytochemical examination shows myeloperoxidase and SBB negative, and a positive for TdT. This hematologic picture is consistent with:

Accepted Answer

A)  ALL 
B)  AML 
C)  CML 
D)  CLL 
E)  None of the above 
A)  ALL 
B)  AML 
C)  CML 
D)  CLL 
E)  None of the above

Question 9

The lymphoblasts found in cases of B-cell acute lymphoblastic leukemia are indistinguishable by cytologic, cytochemical, and immunologic criteria from tumor cells found in __________.

Accepted Answer

A)  Hodgkin's lymphoma 
B)  Chronic lymphocytic leukemia 
C)  Burkitt's lymphoma 
D)  Lymphosarcoma 
E)  L1 ALL 
A)  Hodgkin's lymphoma 
B)  Chronic lymphocytic leukemia 
C)  Burkitt's lymphoma 
D)  Lymphosarcoma 
E)  L1 ALL

Question 10

In performing surface marker analysis for FAB classification M4 and M5, monoclonal antibodies specific for __________ cells would be detected by flow cytometry.

Accepted Answer

A)  Lymphoid 
B)  Monocytic 
C)  Erythroid 
D)  Megakaryocytoid 
E)  None of the above 
A)  Lymphoid 
B)  Monocytic 
C)  Erythroid 
D)  Megakaryocytoid 
E)  None of the above

Question 11

Cytoplasmic marker studies are useful in assessing cell lineage in:

Accepted Answer

A)  ALL 
B)  AML 
C)  CLL 
D)  CML 
E)  Myeloid metaplasia 
A)  ALL 
B)  AML 
C)  CLL 
D)  CML 
E)  Myeloid metaplasia

Question 12

The alpha-naphthyl butyrate stain is used to identify __________ cells.

Accepted Answer

A)  Monocytic 
B)  Granulocytic 
C)  Megakaryocytic 
D)  B lymphocytes 
E)  None of the above 
A)  Monocytic 
B)  Granulocytic 
C)  Megakaryocytic 
D)  B lymphocytes 
E)  None of the above

Question 13

TdT terminal deoxynucleotidyl transferase is found in 90% of acute __________ leukemia.

Accepted Answer

A)  Myelocytic 
B)  Lymphoblastic 
C)  Promyelocytic 
D)  Monocytic 
E)  None of the above 
A)  Myelocytic 
B)  Lymphoblastic 
C)  Promyelocytic 
D)  Monocytic 
E)  None of the above

Question 14

Acute erythroleukemia (M6) is characterized by an abnormal proliferation of __________ and __________ precursors.

Accepted Answer

A)  Erythroid/lymphoid 
B)  Erythroid/myeloid 
C)  Erythroid/megakaryocytoid 
D)  Erythroid/plasmacytoid 
E)  None of the above 
A)  Erythroid/lymphoid 
B)  Erythroid/myeloid 
C)  Erythroid/megakaryocytoid 
D)  Erythroid/plasmacytoid 
E)  None of the above

Question 15

On Romanowsky-stained smears, Auer rods appear as:

Accepted Answer

A)  Brown staining rods 
B)  Orange staining rods 
C)  Pink or purple staining rods 
D)  Blue staining rods 
E)  None of the above 
A)  Brown staining rods 
B)  Orange staining rods 
C)  Pink or purple staining rods 
D)  Blue staining rods 
E)  None of the above

Question 16

Which of the following hematologic findings are consistent with a case of erythroleukemia?

Accepted Answer

A)  Hypercellular bone marrow with marked erythroid hyperplasia 
B)  > 50% of all nucleated cells in bone marrow are abnormal erythroid forms 
C)  Erythroid/megakaryocytoid 
D)  Auer rods present 
E)  All of the above 
A)  Hypercellular bone marrow with marked erythroid hyperplasia 
B)  > 50% of all nucleated cells in bone marrow are abnormal erythroid forms 
C)  Erythroid/megakaryocytoid 
D)  Auer rods present 
E)  All of the above

Question 17

Which FAB classification is used to describe an acute leukemia with a spectrum of monocyte differentiation, including promonocytes and monocytes?

Accepted Answer

A)  M5a 
B)  M3m 
C)  M4 
D)  M4Eo 
E)  M5b 
A)  M5a 
B)  M3m 
C)  M4 
D)  M4Eo 
E)  M5b

Question 18

What is meant by the FAB classification?

Accepted Answer

A)  A system devised by French, American, and British hematologists to standardize morphologic classification of acute myeloid and lymphoid leukemias 
B)  A system devised by French, American, and British hematologists to standardize chronic myeloid and lymphoid leukemias 
C)  A system devised by French, American, and British hematologists to standardize hemolytic anemias 
D)  A system devised by French, American, and British hematologists to standardize lymphomas 
E)  None of the above 
A)  A system devised by French, American, and British hematologists to standardize morphologic classification of acute myeloid and lymphoid leukemias 
B)  A system devised by French, American, and British hematologists to standardize chronic myeloid and lymphoid leukemias 
C)  A system devised by French, American, and British hematologists to standardize hemolytic anemias 
D)  A system devised by French, American, and British hematologists to standardize lymphomas 
E)  None of the above

Question 19

Which cytochemical stain, more specific than SBB stain, should be recommended for granulocytic differentiation?

Accepted Answer

A)  Specific esterase 
B)  Myeloperoxidase 
C)  Nonspecific esterase 
D)  PAS 
E)  Alpha-naphthyl butyrate 
A)  Specific esterase 
B)  Myeloperoxidase 
C)  Nonspecific esterase 
D)  PAS 
E)  Alpha-naphthyl butyrate

Question 20

Which French-American-British classification of ALL typically demonstrates a predominantly uniform population of small blasts with scant cytoplasm, clefting of the nucleus, and variable cytoplasmic vacuolation?

Accepted Answer

A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above 
A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above

Exam 16: Introduction to Leukemia and the Acute Leukemias

Cytoplasmic µ, in the immunologic classification of ALL, is expressed in __________ ALL.

Which cytochemical stains show strong positivity in acute monocytic leukemia (M5)?

Lack of a significant increase in reticulocytes in erythroleukemia is due to:

In leukemia, the presence of immature malignant cells is classified as __________.

What is the ratio of development of leukemia in adults versus children?

Which cytochemical stain is used to detect acute megakaryoblastic leukemia (M7)?

Which of the following cytochemical stains differentiates AML from ALL?

A 5-year-old girl presents with anemia, neutropenia, thrombocytopenia, lymphoblasts, and prolymphocytes. Cytochemical examination shows myeloperoxidase and SBB negative, and a positive for TdT. This hematologic picture is consistent with:

The lymphoblasts found in cases of B-cell acute lymphoblastic leukemia are indistinguishable by cytologic, cytochemical, and immunologic criteria from tumor cells found in __________.

In performing surface marker analysis for FAB classification M4 and M5, monoclonal antibodies specific for __________ cells would be detected by flow cytometry.

Cytoplasmic marker studies are useful in assessing cell lineage in:

The alpha-naphthyl butyrate stain is used to identify __________ cells.

TdT terminal deoxynucleotidyl transferase is found in 90% of acute __________ leukemia.

Acute erythroleukemia (M6) is characterized by an abnormal proliferation of __________ and __________ precursors.

On Romanowsky-stained smears, Auer rods appear as:

Which of the following hematologic findings are consistent with a case of erythroleukemia?

Which FAB classification is used to describe an acute leukemia with a spectrum of monocyte differentiation, including promonocytes and monocytes?

What is meant by the FAB classification?

Which cytochemical stain, more specific than SBB stain, should be recommended for granulocytic differentiation?

Which French-American-British classification of ALL typically demonstrates a predominantly uniform population of small blasts with scant cytoplasm, clefting of the nucleus, and variable cytoplasmic vacuolation?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Acute erythroleukemia (M6) is characterized by an abnormal proliferation of and precursors.