Question 1

Bone marrow failure in acute leukemia is associated with which of the following complications?

Accepted Answer

A)  Anemia 
B)  Thrombocytopenia 
C)  Granulocytopenia 
D)  All of the above 
E)  None of the above 
A)  Anemia 
B)  Thrombocytopenia 
C)  Granulocytopenia 
D)  All of the above 
E)  None of the above

Question 2

The morphology of acute lymphoblastic leukemia is evaluated on a __________ smear.

Accepted Answer

A)  Peripheral blood 
B)  Bone marrow aspirate 
C)  Cytoprep smear 
D)  Fine needle aspiration 
E)  None of the above 
A)  Peripheral blood 
B)  Bone marrow aspirate 
C)  Cytoprep smear 
D)  Fine needle aspiration 
E)  None of the above

Question 3

Anti-leukemia therapy consists of:

Accepted Answer

A)  Cytotoxic chemotherapy 
B)  Radiotherapy 
C)  Bone marrow transplantation 
D)  Hematopoietic stem cell transplant 
E)  All of the above 
A)  Cytotoxic chemotherapy 
B)  Radiotherapy 
C)  Bone marrow transplantation 
D)  Hematopoietic stem cell transplant 
E)  All of the above

Question 4

Cases of pure __________ ALL have the worst prognosis.

Accepted Answer

A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above 
A)  L1 
B)  L2 
C)  L3 
D)  L4 
E)  None of the above

Question 5

Schistocytes or fragmented cells present in promyelocytic acute leukemia (M3) is suggestive of which condition?

Accepted Answer

A)  Hematuria 
B)  DIC 
C)  Liver disease 
D)  Splenomegaly 
E)  None of the above 
A)  Hematuria 
B)  DIC 
C)  Liver disease 
D)  Splenomegaly 
E)  None of the above

Question 6

Cell __________ is used to distinguish between lymphoid and myeloid groups in leukemia.

Accepted Answer

A)  Maturity 
B)  Lineage 
C)  Count 
D)  Kinetics 
E)  None of the above 
A)  Maturity 
B)  Lineage 
C)  Count 
D)  Kinetics 
E)  None of the above

Question 7

"Pre-leukemia" myelodysplastic features in acute myeloid leukemia may include:

Accepted Answer

A)  Hypergranular neutrophils 
B)  Hypogranular neutrophils 
C)  Monocytoid cells 
D)  Plasmacytoid cells 
E)  None of the above 
A)  Hypergranular neutrophils 
B)  Hypogranular neutrophils 
C)  Monocytoid cells 
D)  Plasmacytoid cells 
E)  None of the above

Question 8

Pure cases of L1 ALL are characterized by the presence of __________ L1 blasts.

Accepted Answer

A) >30% B) >50% C) >90% D) <30% E) None of the above A) >30% B) >50% C) >90% D) <30% E) None of the above

Question 9

In immunologic surface marker studies, __________ are used to detect markers associated with cell lineage and maturation stage.

Accepted Answer

A)  Enzymes 
B)  Antigens 
C)  Antibodies 
D)  Haptens 
E)  None of the above 
A)  Enzymes 
B)  Antigens 
C)  Antibodies 
D)  Haptens 
E)  None of the above

Question 10

Which FAB classification demonstrates at least 3% positivity with peroxidase or SBB, <20% positivity with nonspecific esterase, and contains primarily myeloblasts with distinct nucleoli?

Accepted Answer

A)  M2 
B)  M1 
C)  M4 
D)  M3 
E)  None of the above 
A)  M2 
B)  M1 
C)  M4 
D)  M3 
E)  None of the above

Question 11

A 35-year-old man presents with anemia, neutropenia, thrombocytopenia, myeloblasts with the presence of Auer rods, and one or two distinct nucleoli and promyelocytes. Cytochemistry examination demonstrates peroxidase and Sudan black B (SBB) positive and TdT terminal deoxynucleotidyl transferase (TdT) negative. This hematologic picture is consistent with:

Accepted Answer

A)  Acute lymphoblastic leukemia (ALL) 
B)  Acute myeloblastic leukemia (AML) 
C)  Chronic myelocytic leukemia (CML) 
D)  Chronic lymphocytic leukemia (CLL) 
E)  None of the above 
A)  Acute lymphoblastic leukemia (ALL) 
B)  Acute myeloblastic leukemia (AML) 
C)  Chronic myelocytic leukemia (CML) 
D)  Chronic lymphocytic leukemia (CLL) 
E)  None of the above

Question 12

Promyelocytes constitute 10% of this acute leukemia with more than 50% of leukemia cells positive for peroxidase or SBB. What is the FAB leukemia classification?

Accepted Answer

A)  M1 
B)  M2 
C)  M3 
D)  M4 
E)  None of the above 
A)  M1 
B)  M2 
C)  M3 
D)  M4 
E)  None of the above

Question 13

What clinical features suggest a chronic leukemia?

Accepted Answer

A)  Insidious clinical onset 
B)  Mild organomegaly and presence of immature leukemic cells 
C)  Variable white blood cell (WB
C)  count 
D)  Low WBC count 
E)  All of the above 
A)  Insidious clinical onset 
B)  Mild organomegaly and presence of immature leukemic cells 
C)  Variable white blood cell (WB
C)  count 
D)  Low WBC count 
E)  All of the above

Question 14

Which of the following disorders could mimic a case of erythroleukemia?

Accepted Answer

A)  Megaloblastic anemia 
B)  Congenital dyserythropoietic 
C)  Myelodysplastic syndrome 
D)  All of the above 
E)  None of the above 
A)  Megaloblastic anemia 
B)  Congenital dyserythropoietic 
C)  Myelodysplastic syndrome 
D)  All of the above 
E)  None of the above

Exam 16: Introduction to Leukemia and the Acute Leukemias

Bone marrow failure in acute leukemia is associated with which of the following complications?

The morphology of acute lymphoblastic leukemia is evaluated on a __________ smear.

Anti-leukemia therapy consists of:

Cases of pure __________ ALL have the worst prognosis.

Schistocytes or fragmented cells present in promyelocytic acute leukemia (M3) is suggestive of which condition?

Cell __________ is used to distinguish between lymphoid and myeloid groups in leukemia.

"Pre-leukemia" myelodysplastic features in acute myeloid leukemia may include:

Pure cases of L1 ALL are characterized by the presence of __________ L1 blasts.

In immunologic surface marker studies, __________ are used to detect markers associated with cell lineage and maturation stage.

Which FAB classification demonstrates at least 3% positivity with peroxidase or SBB, <20% positivity with nonspecific esterase, and contains primarily myeloblasts with distinct nucleoli?

Promyelocytes constitute 10% of this acute leukemia with more than 50% of leukemia cells positive for peroxidase or SBB. What is the FAB leukemia classification?

What clinical features suggest a chronic leukemia?

Which of the following disorders could mimic a case of erythroleukemia?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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