Question 1

In mammalian cells, cytosolic rRNA

Accepted Answer

A)  is composed of 4 different size classes of RNA. 
B)  is rapidly degraded during protein synthesis. 
C)  is composed of only two types of rRNA. 
D)  contains the codons for protein synthesis. 
E)  is part of the and 6S subunits. 
A)  is composed of 4 different size classes of RNA. 
B)  is rapidly degraded during protein synthesis. 
C)  is composed of only two types of rRNA. 
D)  contains the codons for protein synthesis. 
E)  is part of the and 6S subunits.

Question 2

All of the following are CORRECT statements about the process of transcription (in vivo) EXCEPT

Accepted Answer

A)  accurate transcription involves a protein called sigma which permits RNA polymerase to bind and initiate transcription at specific sites on the DNA molecule. 
B)  the entire DNA molecule is transcribed once transcription begins. 
C)  an mRNA produced as a result of transcription may code for more than one polypeptide chain in prokaryotes. 
D)  a newly synthesized RNA molecule is complementary in base sequence to only one strand of the DNA which served as template. 
A)  accurate transcription involves a protein called sigma which permits RNA polymerase to bind and initiate transcription at specific sites on the DNA molecule. 
B)  the entire DNA molecule is transcribed once transcription begins. 
C)  an mRNA produced as a result of transcription may code for more than one polypeptide chain in prokaryotes. 
D)  a newly synthesized RNA molecule is complementary in base sequence to only one strand of the DNA which served as template.

Question 3

Which of the following is not characteristic of tRNAs?

Accepted Answer

A)  They form extensive secondary structure. 
B)  They have many modified bases. 
C)  They are spliced post-transcriptionally. 
D)  They get nucleotides added to their end post- transcriptionally. 
E)  They contain the codon for translation. 
A)  They form extensive secondary structure. 
B)  They have many modified bases. 
C)  They are spliced post-transcriptionally. 
D)  They get nucleotides added to their end post- transcriptionally. 
E)  They contain the codon for translation.

Question 4

Alternative splicing of mRNA precursors

Accepted Answer

A)  allows the production of different protein products from one gene. 
B)  is usually the consequence of deleterious mutations. 
C)  allows two or more genes to contribute to the production of a single protein. 
D)  gives rise to random mRNA isoforms. 
A)  allows the production of different protein products from one gene. 
B)  is usually the consequence of deleterious mutations. 
C)  allows two or more genes to contribute to the production of a single protein. 
D)  gives rise to random mRNA isoforms.

Question 5

Regarding regulation of transcription, which of the following statements is correct?

Accepted Answer

A)  The CAP protein-cAMP complex binds the lac repressor thereby permitting transcription of the lac operon. 
B)  The lac repressor is a small piece of RNA which binds the operator region of the lac operon. 
C)  The operator region of the lac operon is less than 150 base pairs in length. 
D)  The z gene of the lac operon codes for the lac repressor. 
E)  All of the above. 
A)  The CAP protein-cAMP complex binds the lac repressor thereby permitting transcription of the lac operon. 
B)  The lac repressor is a small piece of RNA which binds the operator region of the lac operon. 
C)  The operator region of the lac operon is less than 150 base pairs in length. 
D)  The z gene of the lac operon codes for the lac repressor. 
E)  All of the above.

Question 6

Regarding RNA synthesis, which of the following statements is correct?

Accepted Answer

A)  The rho subunit is required for chain initiation. 
B)  Synthesis of mRNA from a DNA template strand occurs in a 5 ==> direction anti-parallel to the template. 
C)  The first nucleotide placed in an RNA transcript of prokaryotic cells is GTP and ATP. 
D)  Both A and B are correct. 
E)  Both B and C are correct. 
A)  The rho subunit is required for chain initiation. 
B)  Synthesis of mRNA from a DNA template strand occurs in a 5 ==> direction anti-parallel to the template. 
C)  The first nucleotide placed in an RNA transcript of prokaryotic cells is GTP and ATP. 
D)  Both A and B are correct. 
E)  Both B and C are correct.

Question 7

Which of the following RNAs are synthesized in the nucleolus?

Accepted Answer

A)  5S rRNA 
B)  tRNA 
C)  28S rRNA 
D)  mRNA 
E)  Both A and C 
A)  5S rRNA 
B)  tRNA 
C)  28S rRNA 
D)  mRNA 
E)  Both A and C

Question 8

The messenger RNA codon for histidine is CAU. The sequence of the DNA template strand for this mRNA is (all written 5' to

Accepted Answer

A)  GTA. 
B)  ATG. 
C)  CAU. 
D)  CAT. 
E)  none of the above 
A)  GTA. 
B)  ATG. 
C)  CAU. 
D)  CAT. 
E)  none of the above

Question 9

Transcription of the following DNA segment proceeds from left to right. ..ATTCAG.5' 5'.TAAGTC. The sequence of the resulting RNA is

Accepted Answer

A)  5'.GUCUUA. 
B)  5'.AUUCUG. 
C)  5'.UAAGUC. 
D)  5'.CUGAAU. 
E)  none of the above. 
A)  5'.GUCUUA. 
B)  5'.AUUCUG. 
C)  5'.UAAGUC. 
D)  5'.CUGAAU. 
E)  none of the above.

Question 10

What is the main function of the nucleolus?

Accepted Answer

A)  Site of synthesis of ribosomal protein. 
B)  Site of synthesis of ribosomal RNA. 
C)  Site of synthesis of DNA which directs formation of transfer RNA. 
D)  Site of synthesis of messenger RNA. 
E)  Site of messenger RNA translation. 
A)  Site of synthesis of ribosomal protein. 
B)  Site of synthesis of ribosomal RNA. 
C)  Site of synthesis of DNA which directs formation of transfer RNA. 
D)  Site of synthesis of messenger RNA. 
E)  Site of messenger RNA translation.

Question 11

Polysomes are

Accepted Answer

A)  polycistronic messengers bound to RNA polymerase. 
B)  polycistronic messengers bound to DNA polymerase. 
C)  polycistronic messengers bound to a single ribosome. 
D)  a group of ribosomes bound to different sections of the same mRNA with each ribosome engaged in the synthesis of the same kind of polypeptide chain. 
E)  none of the above 
A)  polycistronic messengers bound to RNA polymerase. 
B)  polycistronic messengers bound to DNA polymerase. 
C)  polycistronic messengers bound to a single ribosome. 
D)  a group of ribosomes bound to different sections of the same mRNA with each ribosome engaged in the synthesis of the same kind of polypeptide chain. 
E)  none of the above

Question 12

Leucine zipper domains found in many transcription factors function directly in

Accepted Answer

A)  DNA binding. 
B)  transactivation. 
C)  dimerization. 
D)  zinc binding. 
A)  DNA binding. 
B)  transactivation. 
C)  dimerization. 
D)  zinc binding.

Question 13

All of the following are determinants of transcription activation EXCEPT

Accepted Answer

A)  Trans_acting proteins and cofactors. 
B)  Cis_acting elements. 
C)  mRNA processing. 
D)  Locus arrangement. 
E)  Chromatin structure. 
A)  Trans_acting proteins and cofactors. 
B)  Cis_acting elements. 
C)  mRNA processing. 
D)  Locus arrangement. 
E)  Chromatin structure.

Question 14

A drug that specifically affects the activity of RNA polymerase I would be expected to most DIRECTLY affect which of the following processes?

Accepted Answer

A)  ribosome assembly 
B)  spliceosome assembly 
C)  synthesis of RNA polymerases II and III. 
D)  regulation of RNA polymerases II and III. 
E)  assembly of the RNA polymerase I, II and III complex. 
A)  ribosome assembly 
B)  spliceosome assembly 
C)  synthesis of RNA polymerases II and III. 
D)  regulation of RNA polymerases II and III. 
E)  assembly of the RNA polymerase I, II and III complex.

Question 15

All of the statements concerning the cap on mRNA are TRUE EXCEPT

Accepted Answer

A)  the methyl groups are contributed by S-adenosyl methionine. 
B)  it is located at the 5' end of eukaryotic mRNA. 
C)  its structure includes 7 methyl guanine. 
D)  its structure may include 2'0-methyl groups. 
E)  an RNA polymerase is responsible for adding this structure to the primary transcript. 
A)  the methyl groups are contributed by S-adenosyl methionine. 
B)  it is located at the 5' end of eukaryotic mRNA. 
C)  its structure includes 7 methyl guanine. 
D)  its structure may include 2'0-methyl groups. 
E)  an RNA polymerase is responsible for adding this structure to the primary transcript.

Question 16

Splicing occurs

Accepted Answer

A)  in the nucleus, by removing introns from DNA. 
B)  in the nucleus, prior to transcription. 
C)  in the nucleus, either during or subsequent to transcription. 
D)  in the cytoplasm, prior to translation. 
E)  in the cytoplasm, subsequent to translation. 
A)  in the nucleus, by removing introns from DNA. 
B)  in the nucleus, prior to transcription. 
C)  in the nucleus, either during or subsequent to transcription. 
D)  in the cytoplasm, prior to translation. 
E)  in the cytoplasm, subsequent to translation.

Question 17

Genes containing intervening sequences (or introns)

Accepted Answer

A)  are rare in eukaryotic cells. 
B)  code for mRNA precursors which must be spliced before translation. 
C)  must undergo a DNA rearrangement before expression. 
D)  do not code for proteins. 
E)  are common in prokaryotes. 
A)  are rare in eukaryotic cells. 
B)  code for mRNA precursors which must be spliced before translation. 
C)  must undergo a DNA rearrangement before expression. 
D)  do not code for proteins. 
E)  are common in prokaryotes.

Question 18

Mammalian RNA polymerase II

Accepted Answer

A)  synthesizes rRNA. 
B)  synthesizes mRNA. 
C)  synthesizes tRNA. 
D)  is least sensitive to alpha-amanitin. 
E)  None of the other answers is correct. 
A)  synthesizes rRNA. 
B)  synthesizes mRNA. 
C)  synthesizes tRNA. 
D)  is least sensitive to alpha-amanitin. 
E)  None of the other answers is correct.

Question 19

The synthesis of RNA complementary to one strand of the DNA is termed

Accepted Answer

A)  translation. 
B)  replication. 
C)  reverse transcription. 
D)  transcription. 
E)  transformation. 
A)  translation. 
B)  replication. 
C)  reverse transcription. 
D)  transcription. 
E)  transformation.

Question 20

The synthesis of which of the following eukaryotic RNAs would be most severely inhibited by the mushroom toxin alpha-amanitin?

Accepted Answer

A)  mitochondrial RNA 
B)  hnRNA 
C)  rRNA 
D)  tRNA 
E)  7SL RNA 
A)  mitochondrial RNA 
B)  hnRNA 
C)  rRNA 
D)  tRNA 
E)  7SL RNA

Exam 5: RNA: Transcription and Rna Processing

In mammalian cells, cytosolic rRNA

All of the following are CORRECT statements about the process of transcription (in vivo) EXCEPT

Which of the following is not characteristic of tRNAs?

Alternative splicing of mRNA precursors

Regarding regulation of transcription, which of the following statements is correct?

Regarding RNA synthesis, which of the following statements is correct?

Which of the following RNAs are synthesized in the nucleolus?

The messenger RNA codon for histidine is CAU. The sequence of the DNA template strand for this mRNA is (all written 5' to

Transcription of the following DNA segment proceeds from left to right. ..ATTCAG.5' 5'.TAAGTC. The sequence of the resulting RNA is

What is the main function of the nucleolus?

Polysomes are

Leucine zipper domains found in many transcription factors function directly in

All of the following are determinants of transcription activation EXCEPT

A drug that specifically affects the activity of RNA polymerase I would be expected to most DIRECTLY affect which of the following processes?

All of the statements concerning the cap on mRNA are TRUE EXCEPT

Splicing occurs

Genes containing intervening sequences (or introns)

Mammalian RNA polymerase II

The synthesis of RNA complementary to one strand of the DNA is termed

The synthesis of which of the following eukaryotic RNAs would be most severely inhibited by the mushroom toxin alpha-amanitin?

Eukaryotic Cell Structure

DNA and RNA: Composition and Structure

Protein I: Composition and Structure

DNA Replication, Recombination, and Repair

Protein Synthesis: Translation and Posttranslational Modifications

Recombinant Dna and Biotechnology

Regulation of Gene Expression

Protein II: Structure-Function Relationships in Protein Families

Enzymes: Classification, Kinetics, and Control

The Cytochromes P450 and Nitric Oxide Synthases

Biological Membranes: Structure and Membrane Transport

Fundamentals of Signal Transduction

Bioenergetics and Oxidative Metabolism

Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control

Carbohydrate Metabolism II: Special Pathways and Glycoconjugates

Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols

Lipid Metabolism II: Pathways of Metabolism of Special Lipids

Amino Acid Metabolism

Purine and Pyrimidine Nucleotide Metabolism

Metabolic Interrelationships

Biochemistry of Hormones

Molecular Cell Biology

Cell Cycle, Programmed Cell Death, and Cancer

Digestion and Absorption of Basic Nutritional Constituents

Digestion and Absorption of Basic Nutritional Constituents

Principles of Nutrition I and II

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