Question 1

Describe why allelic phase is a major obstacle in mapping human genes.

Accepted Answer

Allelic phase is the arrangement of diff

Question 2

Recombination analysis allows for the mapping of genes because the frequency of crossing over is proportional to what distance?

Accepted Answer

distance b

Question 3

The alleles of linked genes tend to __________.

Accepted Answer

A) segregate together during gamete production 
B) assort independently 
C) be mutated more often than unlinked genes 
D) experience a higher rate of crossing over 
E) assort independently and show a higher rate of crossing over 
A) segregate together during gamete production 
B) assort independently 
C) be mutated more often than unlinked genes 
D) experience a higher rate of crossing over 
E) assort independently and show a higher rate of crossing over

Question 4

Incomplete genetic linkage of three genes in a trihybrid produces eight genetically different gamete genotypes. How many different gamete genotypes are produced in a four-gene cross with incomplete genetic linkage?

Accepted Answer

A) 4 
B) 8 
C) 16 
D) 20 
E) 24 
A) 4 
B) 8 
C) 16 
D) 20 
E) 24

Question 5

How is Newton Morton's statistical method helpful for calculating the overall probability of genetic linkage when allelic phase is unknown?

Accepted Answer

Morton's method determines whether genet

Question 6

In a two-point test-cross analysis, what are the "two points" being tested?

Accepted Answer

The answer of In a two-point test-cross analysis, what are...

Question 7

The Zmax from the analysis of a disease gene N and the DNA marker H was 2.5 at θ = 0.1. Which of the following is the best interpretation of this result?

Accepted Answer

A) N and H are not linked. 
B) N and H are separated by 10 cM. 
C) N and H are separated by more than 10 cM. 
D) N and H are separated by less than 10 cM. 
E) No conclusion can be made regarding the linkage of N and H. 
A) N and H are not linked. 
B) N and H are separated by 10 cM. 
C) N and H are separated by more than 10 cM. 
D) N and H are separated by less than 10 cM. 
E) No conclusion can be made regarding the linkage of N and H.

Question 8

The mapping of the human genome in the mid-1980s was integral for identifying new human genetic markers because of the identification of what types of polymorphic DNA markers?

Accepted Answer

SNPs and r

Question 9

What organism exhibits complete genetic linkage, meaning there is no recombination between homologous chromosomes?

Accepted Answer

male Droso

Question 10

Genes A and B are located 10cM from each other on a chromosome. Gene C is located 25cM from gene A and 15cM from gene B. What is the probability that the trihybrid ABC/abc will produce any kind of recombinant gamete?

Accepted Answer

A) 76.5% 
B) 38.25% 
C) 23.5% 
D) 1.5% 
E) 0.75% 
A) 76.5% 
B) 38.25% 
C) 23.5% 
D) 1.5% 
E) 0.75%

Question 11

For a given cross, the expected number of double recombinants is 20 and the observed number of double recombinants is 15. What is the coefficient of coincidence (c)?

Accepted Answer

A) 0.25 
B) 1.33 
C) 20 
D) 0.75 
E) 15 
A) 0.25 
B) 1.33 
C) 20 
D) 0.75 
E) 15

Question 12

What is the relationship between linked genes and syntenic genes? Are syntenic genes always linked?Are linked genes always syntenic? Describe what is meant by each term.

Accepted Answer

Linked genes are always inherited togeth

Question 13

What is the term for chromosomes that do not reshuffle the alleles of linked genes?

Accepted Answer

parental c

Question 14

Which type of crossover event produces all four recombinant chromosomes?

Accepted Answer

A) single-strand crossover 
B) two-strand double crossover 
C) three-strand double crossover 
D) four-strand double crossover 
E) None of the above; all crossover events produce a combination of parental and recombinant chromosomes. 
A) single-strand crossover 
B) two-strand double crossover 
C) three-strand double crossover 
D) four-strand double crossover 
E) None of the above; all crossover events produce a combination of parental and recombinant chromosomes.

Question 15

What is the highest possible frequency of recombination between linked genes that can be generated by any type of crossover event?

Accepted Answer

The answer of What is the highest possible frequency of...

Question 16

Assuming three genes are linked, how many recombinant genotypes would you expect and at what frequency?

Accepted Answer

A) two recombinant genotypes, more frequent than expected by independent assortment 
B) four recombinant genotypes, more frequent than expected by independent assortment 
C) six recombinant genotypes, more frequent than expected by independent assortment 
D) four recombinant genotypes, less frequent than expected by independent assortment 
E) six recombinant genotypes, less frequent than expected by independent assortment 
A) two recombinant genotypes, more frequent than expected by independent assortment 
B) four recombinant genotypes, more frequent than expected by independent assortment 
C) six recombinant genotypes, more frequent than expected by independent assortment 
D) four recombinant genotypes, less frequent than expected by independent assortment 
E) six recombinant genotypes, less frequent than expected by independent assortment

Question 17

Ascospores in yeast are not arranged in a particular order. Thus, the four haploid ascospores contained within a yeast ascus are known as what?

Accepted Answer

The answer of Ascospores in yeast are not arranged in...

Question 18

What would a Lod score of 3.2 tell you about genetic linkage? What information does the θ value tell you?

Accepted Answer

Scores of greater than 3.0 pro

Question 19

What is the Lod score?

Accepted Answer

The ratio of the two likelihoods describ

Question 20

Which type of crossover event produces two parental and two recombinant chromosomes in gametes?

Accepted Answer

A) single-strand crossover 
B) two-strand double crossover 
C) three-strand double crossover 
D) four-strand double crossover 
E) None of the above; all crossover events produce only recombinant chromosomes. 
A) single-strand crossover 
B) two-strand double crossover 
C) three-strand double crossover 
D) four-strand double crossover 
E) None of the above; all crossover events produce only recombinant chromosomes.

Exam 5: Genetic Linkage and Mapping in Eukaryotes

Describe why allelic phase is a major obstacle in mapping human genes.

Recombination analysis allows for the mapping of genes because the frequency of crossing over is proportional to what distance?

The alleles of linked genes tend to __________.

Incomplete genetic linkage of three genes in a trihybrid produces eight genetically different gamete genotypes. How many different gamete genotypes are produced in a four-gene cross with incomplete genetic linkage?

How is Newton Morton's statistical method helpful for calculating the overall probability of genetic linkage when allelic phase is unknown?

In a two-point test-cross analysis, what are the "two points" being tested?

The Zmax from the analysis of a disease gene N and the DNA marker H was 2.5 at θ = 0.1. Which of the following is the best interpretation of this result?

The mapping of the human genome in the mid-1980s was integral for identifying new human genetic markers because of the identification of what types of polymorphic DNA markers?

What organism exhibits complete genetic linkage, meaning there is no recombination between homologous chromosomes?

Genes A and B are located 10cM from each other on a chromosome. Gene C is located 25cM from gene A and 15cM from gene B. What is the probability that the trihybrid ABC/abc will produce any kind of recombinant gamete?

For a given cross, the expected number of double recombinants is 20 and the observed number of double recombinants is 15. What is the coefficient of coincidence (c)?

What is the relationship between linked genes and syntenic genes? Are syntenic genes always linked?Are linked genes always syntenic? Describe what is meant by each term.

What is the term for chromosomes that do not reshuffle the alleles of linked genes?

Which type of crossover event produces all four recombinant chromosomes?

What is the highest possible frequency of recombination between linked genes that can be generated by any type of crossover event?

Assuming three genes are linked, how many recombinant genotypes would you expect and at what frequency?

Ascospores in yeast are not arranged in a particular order. Thus, the four haploid ascospores contained within a yeast ascus are known as what?

What would a Lod score of 3.2 tell you about genetic linkage? What information does the θ value tell you?

What is the Lod score?

Which type of crossover event produces two parental and two recombinant chromosomes in gametes?

The Molecular Basis of Heredity, Variation, and Evolution

Transmission Genetics

Cell Division and Chromosome Heredity

Gene Interaction

Genetic Analysis and Mapping in Bacteria and Bacteriophages

Dna Structure and Replication

Molecular Biology and Transcription and Rna Processing

The Molecular Biology of Translation

The Integration of Genetic Approaches: Understanding Sickle Cell Disease

Chromosome Structure

Gene Mutation, Dna Repair, and Homologous Recombination

Chromosome Aberrations and Transposition

Regulation of Gene Expression in Bacteria and Bacteriophages

Regulation of Gene Expression in Eukaryotes

Forward Genetics and Recombinant Dna Technology

Applications of Recombinant Dna Technology and Reverse Genetics

Genomics: Genetics From a Whole-Genome Perspective

Cytoplasmic Inheritance and the Evolution of Organelle Genomes

Developmental Genetics

Genetic Analysis of Quantitative Traits

Population Genetics and Evolution

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The Z_max from the analysis of a disease gene N and the DNA marker H was 2.5 at θ = 0.1. Which of the following is the best interpretation of this result?