Question 1

If complement CH50 is decreased and complement AH50 is normal in a specimen, the specimen may be deficient in factor(s)

Accepted Answer

A) properdin. 
B) C3. 
C) C1, C2, or C4. 
D) Factor B. 
E) C5, C6, C7, C8, or C9. 
A) properdin. 
B) C3. 
C) C1, C2, or C4. 
D) Factor B. 
E) C5, C6, C7, C8, or C9. C

Question 2

Each complement component below is an anaphylotoxin except

Accepted Answer

A) C3a 
B) C4a 
C) C5a 
D) C2a 
A) C3a 
B) C4a 
C) C5a 
D) C2a D

Question 3

Systemic lupus erythematosus is highly associated with C1q genetic deficiency.

Accepted Answer

A) True 
 B)False  True

Question 4

The only complement receptor on red blood cells is CR4.

Accepted Answer

A) True 
 B)False

Question 5

In what way(s)is complement antiviral?

Accepted Answer

A) Can opsonize viral particle. 
B) Can directly disrupt viral particle. 
C) Can block viral receptors. 
D) All of the above. 
A) Can opsonize viral particle. 
B) Can directly disrupt viral particle. 
C) Can block viral receptors. 
D) All of the above.

Question 6

In the complement fixation test, the presence of an antibody/antigen reaction is detected because

Accepted Answer

A) it precipitates complement proteins. 
B) complement C5-9 are consumed in the specimen. 
C) complement is bound and is unavailable to lyse sensitized red blood cells. 
D) complement is activated and it lyses red blood cells. 
E) complement C3 is consumed in the specimen. 
A) it precipitates complement proteins. 
B) complement C5-9 are consumed in the specimen. 
C) complement is bound and is unavailable to lyse sensitized red blood cells. 
D) complement is activated and it lyses red blood cells. 
E) complement C3 is consumed in the specimen.

Question 7

A specimen has a reduced total hemolytic complement as measured by CH50. When individual components were measured, total C3 was very reduced, but total C4 was within normal limits. How can these results be best explained?

Accepted Answer

A) The subject has severe liver disease. 
B) There has been a recent significant activation of the mannose binding lectin complement path. 
C) There has been a recent significant activation of the alternate complement path. 
D) There has been a recent significant activation of the classic complement path. 
A) The subject has severe liver disease. 
B) There has been a recent significant activation of the mannose binding lectin complement path. 
C) There has been a recent significant activation of the alternate complement path. 
D) There has been a recent significant activation of the classic complement path.

Question 8

Discuss how the anaphylotoxin complement fragments promote a better immune response.

Accepted Answer

The complement fragments that function a

Question 9

All of the following are functions of complement except

Accepted Answer

A) chemotaxis. 
B) specific, selective antigen binding. 
C) anaphylotoxin. 
D) cell lysis. 
E) opsonization. 
A) chemotaxis. 
B) specific, selective antigen binding. 
C) anaphylotoxin. 
D) cell lysis. 
E) opsonization.

Question 10

Explain why one molecule of IgM can activate complement but it takes about 1000 molecules of IgG on a cell surface to activate complement.

Accepted Answer

Complement is activated by the classic p

Question 11

All of the following are properties of complement fragment C5a except

Accepted Answer

A) promotes ability of neutrophils to adhere to blood vessel walls. 
B) serves as initial binding molecule of the membrane attack complex. 
C) promotes increases expression of complement 1 receptor on phagocytes. 
D) promotes adherence of red blood cells, lymphocytes, and endothelial cells to material requiring phagocytosis. 
E) most potent chemotactic fragment. 
A) promotes ability of neutrophils to adhere to blood vessel walls. 
B) serves as initial binding molecule of the membrane attack complex. 
C) promotes increases expression of complement 1 receptor on phagocytes. 
D) promotes adherence of red blood cells, lymphocytes, and endothelial cells to material requiring phagocytosis. 
E) most potent chemotactic fragment.

Question 12

For each of the three complement pathways, once C5 is split into C5a and C5b, formation of the membrane attack complex is identical for all three paths.

Accepted Answer

A) True 
 B)False

Question 13

Each complement component below is an opsonin except

Accepted Answer

A) C4a 
B) C3b 
C) iC3b 
D) C1qrs 
A) C4a 
B) C3b 
C) iC3b 
D) C1qrs

Question 14

A person with a genetic deficiency in complement C3 would be predisposed to have

Accepted Answer

A) immune complex diseases. 
B) accelerated, chronic inflammatory reactions. 
C) recurrent bacterial infections. 
D) autoimmune diseases. 
E) no discernible effect since deficiencies in the classic pathway can be compensated for by the alternate and mannose binding lectin pathways. 
A) immune complex diseases. 
B) accelerated, chronic inflammatory reactions. 
C) recurrent bacterial infections. 
D) autoimmune diseases. 
E) no discernible effect since deficiencies in the classic pathway can be compensated for by the alternate and mannose binding lectin pathways.

Question 15

What is (are)the consequence(s)of complement C3 being cleaved into C3a and C3b in the classic pathway?

Accepted Answer

A) C3b complexes with C2a4b to form C5 convertase. 
B) C3a enters the plasma as an anaphylotoxin. 
C) C3b attaches to the cell membrane as an opsonin. 
D) All of the above. 
A) C3b complexes with C2a4b to form C5 convertase. 
B) C3a enters the plasma as an anaphylotoxin. 
C) C3b attaches to the cell membrane as an opsonin. 
D) All of the above.

Question 16

Which complement regulatory protein is expressed on red blood cells to prevent them from being damaged by complement?

Accepted Answer

A) C4 binding protein 
B) C1 inhibitor 
C) S protein 
D) Factor H 
E) decay accelerating factor 
A) C4 binding protein 
B) C1 inhibitor 
C) S protein 
D) Factor H 
E) decay accelerating factor

Question 17

What is the recognition unit in the classic complement pathway?

Accepted Answer

A) Factor B and properdin 
B) mannose and mannose binding lectin 
C) C2 and C4 
D) C1qrs 
E) C3 
A) Factor B and properdin 
B) mannose and mannose binding lectin 
C) C2 and C4 
D) C1qrs 
E) C3

Question 18

List the three stages of complement cascade.

Accepted Answer

1. Recognition-identifying a situation i

Question 19

The only complement receptor on red blood cells is ________.

Accepted Answer

CR1 or com

Question 20

The most abundant complement component in plasma is________.

Accepted Answer

The answer of The most abundant complement component in plasma...

If complement CH50 is decreased and complement AH50 is normal in a specimen, the specimen may be deficient in factor(s)

Each complement component below is an anaphylotoxin except

Systemic lupus erythematosus is highly associated with C1q genetic deficiency.

The only complement receptor on red blood cells is CR4.

In what way(s)is complement antiviral?

In the complement fixation test, the presence of an antibody/antigen reaction is detected because

A specimen has a reduced total hemolytic complement as measured by CH50. When individual components were measured, total C3 was very reduced, but total C4 was within normal limits. How can these results be best explained?

Discuss how the anaphylotoxin complement fragments promote a better immune response.

All of the following are functions of complement except

Explain why one molecule of IgM can activate complement but it takes about 1000 molecules of IgG on a cell surface to activate complement.

All of the following are properties of complement fragment C5a except

For each of the three complement pathways, once C5 is split into C5a and C5b, formation of the membrane attack complex is identical for all three paths.

Each complement component below is an opsonin except

A person with a genetic deficiency in complement C3 would be predisposed to have

What is (are)the consequence(s)of complement C3 being cleaved into C3a and C3b in the classic pathway?

Which complement regulatory protein is expressed on red blood cells to prevent them from being damaged by complement?

What is the recognition unit in the classic complement pathway?

List the three stages of complement cascade.

The only complement receptor on red blood cells is ________.

The most abundant complement component in plasma is________.

What Is Immunology

Overview of the Immune System

Immunoglobulins

Infection and Immunity: Hostparasite Relationships

Hypersensitivity

Immunologic Detection of Infectious Diseases

Autoimmune Diseases and Immunodeficiency Disorders

Transplant Immunology

Tumor Immunology

Clinical Applications of Flow Cytometry

Hybridization Techniques

Amplification Techniques

Molecular Applications in Cytogenetics

Histocompatibility Laboratory Techniques and Applications

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Exam 5: The Complement System

If complement CH50 is decreased and complement AH50 is normal in a specimen, the specimen may be deficient in factor(s)

Each complement component below is an anaphylotoxin except

Systemic lupus erythematosus is highly associated with C1q genetic deficiency.

The only complement receptor on red blood cells is CR4.

In what way(s)is complement antiviral?

In the complement fixation test, the presence of an antibody/antigen reaction is detected because

A specimen has a reduced total hemolytic complement as measured by CH50. When individual components were measured, total C3 was very reduced, but total C4 was within normal limits. How can these results be best explained?

Discuss how the anaphylotoxin complement fragments promote a better immune response.

All of the following are functions of complement except

Explain why one molecule of IgM can activate complement but it takes about 1000 molecules of IgG on a cell surface to activate complement.

All of the following are properties of complement fragment C5a except

For each of the three complement pathways, once C5 is split into C5a and C5b, formation of the membrane attack complex is identical for all three paths.

Each complement component below is an opsonin except

A person with a genetic deficiency in complement C3 would be predisposed to have

What is (are)the consequence(s)of complement C3 being cleaved into C3a and C3b in the classic pathway?

Which complement regulatory protein is expressed on red blood cells to prevent them from being damaged by complement?

What is the recognition unit in the classic complement pathway?

List the three stages of complement cascade.

The only complement receptor on red blood cells is ________.

The most abundant complement component in plasma is________.

What Is Immunology

Overview of the Immune System

Immunoglobulins

Infection and Immunity: Hostparasite Relationships

Hypersensitivity

Immunologic Detection of Infectious Diseases

Autoimmune Diseases and Immunodeficiency Disorders

Transplant Immunology

Tumor Immunology

Clinical Applications of Flow Cytometry

Hybridization Techniques

Amplification Techniques

Molecular Applications in Cytogenetics

Histocompatibility Laboratory Techniques and Applications

Filters