Question 1

Which of the following cell wall components can initiate the mannose binding lection pathway of complement activation?

Accepted Answer

A) Glucose 
B) Mannose 
C) Fucose 
D) N- acetylglucosamine 
E) All of the above 
A) Glucose 
B) Mannose 
C) Fucose 
D) N- acetylglucosamine 
E) All of the above

Question 2

Which of the following are TRUE regarding the alternate pathway of complement activation?

Accepted Answer

A) Factor D has a similar function to C1qrs, and Factor B has a similar function to C2. 
B) The activation surface of an organism serves to spontaneously cleave C3 into C3a and C3b. 
C) Unlike the classic complement pathway, the alternate pathway is independent of calcium and magnesium. 
D) The composition of the C3 convertase is a Factor B/Properdin complex. 
A) Factor D has a similar function to C1qrs, and Factor B has a similar function to C2. 
B) The activation surface of an organism serves to spontaneously cleave C3 into C3a and C3b. 
C) Unlike the classic complement pathway, the alternate pathway is independent of calcium and magnesium. 
D) The composition of the C3 convertase is a Factor B/Properdin complex.

Question 3

The C3 convertases for the classic and mannose binding lectin paths of complement activation are identical.

Accepted Answer

A) True 
 B)False

Question 4

The abbreviation C3a in relation to complement gives what information?

Accepted Answer

A) The capital C indicates this is a complement component. 
B) The lower case letter indicates that this is a fragment of the component. 
C) The numeral tells which complement component. 
D) All of the above. 
A) The capital C indicates this is a complement component. 
B) The lower case letter indicates that this is a fragment of the component. 
C) The numeral tells which complement component. 
D) All of the above.

Question 5

The complement system is a group of proteins solely comprised of activators and substrates for the system.

Accepted Answer

A) True 
 B)False

Question 6

When antigen binds to antibody, the ________ is (are) activated.

Accepted Answer

A) mannose binding pathway 
B) alternate pathway 
C) classic pathway 
D) All of the above 
A) mannose binding pathway 
B) alternate pathway 
C) classic pathway 
D) All of the above

Question 7

Hereditary angioedema is associated with a deficiency in________.

Accepted Answer

C1 INH or

Question 8

Describe the mechanism of acquired (nongenetic)complement deficiency.

Accepted Answer

Complement components can become deficie

Question 9

Which of the following is TRUE regarding the C3 convertase in the classic complement pathway?

Accepted Answer

A) Magnesium is required to stabilize the complex. 
B) It is incorporated into the membrane attack unit. 
C) It is inactivated once it splits a C3 molecule into C3a and C3b. 
D) Its composition is C2bC4a. 
E) All of the above. 
A) Magnesium is required to stabilize the complex. 
B) It is incorporated into the membrane attack unit. 
C) It is inactivated once it splits a C3 molecule into C3a and C3b. 
D) Its composition is C2bC4a. 
E) All of the above.

Question 10

The activated components of complement are generally very stable to promote a long period of activity and shortened time of infection.

Accepted Answer

A) True 
 B)False

Question 11

Which of the following is TRUE regarding paroxysmal nocturnal hemoglobinuria (PNH)?

Accepted Answer

A) It can be diagnosed by the deficiency of CD55 and CD59 on red blood cells. 
B) Red blood cells are deficient in the complement regulatory proteins DAF (decay accelerating factor)and protectin. 
C) Symptoms include lysis of red blood cells with hemoglobin appearing in the urine and a tendency to develop blood clots. 
D) All of the above. 
A) It can be diagnosed by the deficiency of CD55 and CD59 on red blood cells. 
B) Red blood cells are deficient in the complement regulatory proteins DAF (decay accelerating factor)and protectin. 
C) Symptoms include lysis of red blood cells with hemoglobin appearing in the urine and a tendency to develop blood clots. 
D) All of the above.

Question 12

Complement components are completely destroyed if a specimen is

Accepted Answer

A) kept at body temperature for 30 minutes. 
B) kept at room temperature for 30 minutes. 
C) frozen. 
D) heated to 56° C for 30 minutes. 
E) All of the above. 
A) kept at body temperature for 30 minutes. 
B) kept at room temperature for 30 minutes. 
C) frozen. 
D) heated to 56° C for 30 minutes. 
E) All of the above.

Question 13

When there is a complement deficiency, the CH50 increases.

Accepted Answer

A) True 
 B)False

Question 14

All of the following conditions have been associated with deficiencies in complement regulatory proteins except

Accepted Answer

A) hereditary angioedema. 
B) paroxysmal nocturnal hemoglobinuria. 
C) chronic susceptibility to Neisseria infections. 
D) systemic lupus erythematosus. 
E) hemolytic- uremic syndrome. 
A) hereditary angioedema. 
B) paroxysmal nocturnal hemoglobinuria. 
C) chronic susceptibility to Neisseria infections. 
D) systemic lupus erythematosus. 
E) hemolytic- uremic syndrome.

Question 15

Complement fragments only attach to foreign cells, not host cells.

Accepted Answer

A) True 
 B)False

Question 16

The cells with receptors for the anaphylotoxins are________.

Accepted Answer

mast cells

Question 17

What is (are)the consequence(s)of complement C5 being cleaved into C5a and C5b?

Accepted Answer

A) C5a perforates the cell membrane. 
B) C5b binds to C6, C7, C8, and C9. 
C) C5b is released into the plasma as a potent anaphylotoxin. 
D) All of the above. 
A) C5a perforates the cell membrane. 
B) C5b binds to C6, C7, C8, and C9. 
C) C5b is released into the plasma as a potent anaphylotoxin. 
D) All of the above.

Question 18

A complement fixation test is done to see if a specimen contains antibodies to rubella virus. A control negative for antibodies and a control positive for antibodies are run, and the sensitized sheep cells are tested alone with no specimen or complement added. Which of reactions below is correct if the specimen does contain antibodies?

Accepted Answer

A) Positive control, no lysis; negative control, lysis; specimen, no lysis; red cells no lysis 
B) Positive control, lysis; negative control, no lysis; specimen, lysis; red cells lysis 
C) Positive control, lysis; negative control, no lysis; specimen, lysis; red cells no lysis 
D) Positive control, no lysis; negative control, lysis; specimen, no lysis; red cells lysis 
A) Positive control, no lysis; negative control, lysis; specimen, no lysis; red cells no lysis 
B) Positive control, lysis; negative control, no lysis; specimen, lysis; red cells lysis 
C) Positive control, lysis; negative control, no lysis; specimen, lysis; red cells no lysis 
D) Positive control, no lysis; negative control, lysis; specimen, no lysis; red cells lysis

Question 19

Which complement regulatory protein(s)below act(s)to prevent initial complement activation? (Check as many as apply.)

Accepted Answer

A) C1 inhibitor 
B) decay accelerating factor 
C) Factor I 
D) C4 binding protein 
E) Factor H 
A) C1 inhibitor 
B) decay accelerating factor 
C) Factor I 
D) C4 binding protein 
E) Factor H

Question 20

Name one complement regulatory protein that inhibits the membrane attack complex.

Accepted Answer

CD59, S protein, hom

Which of the following cell wall components can initiate the mannose binding lection pathway of complement activation?

Which of the following are TRUE regarding the alternate pathway of complement activation?

The C3 convertases for the classic and mannose binding lectin paths of complement activation are identical.

The abbreviation C3a in relation to complement gives what information?

The complement system is a group of proteins solely comprised of activators and substrates for the system.

When antigen binds to antibody, the ________ is (are) activated.

Hereditary angioedema is associated with a deficiency in________.

Describe the mechanism of acquired (nongenetic)complement deficiency.

Which of the following is TRUE regarding the C3 convertase in the classic complement pathway?

The activated components of complement are generally very stable to promote a long period of activity and shortened time of infection.

Which of the following is TRUE regarding paroxysmal nocturnal hemoglobinuria (PNH)?

Complement components are completely destroyed if a specimen is

When there is a complement deficiency, the CH50 increases.

All of the following conditions have been associated with deficiencies in complement regulatory proteins except

Complement fragments only attach to foreign cells, not host cells.

The cells with receptors for the anaphylotoxins are________.

What is (are)the consequence(s)of complement C5 being cleaved into C5a and C5b?

Which complement regulatory protein(s)below act(s)to prevent initial complement activation? (Check as many as apply.)

Name one complement regulatory protein that inhibits the membrane attack complex.

What Is Immunology

Overview of the Immune System

Immunoglobulins

Infection and Immunity: Hostparasite Relationships

Hypersensitivity

Immunologic Detection of Infectious Diseases

Autoimmune Diseases and Immunodeficiency Disorders

Transplant Immunology

Tumor Immunology

Clinical Applications of Flow Cytometry

Hybridization Techniques

Amplification Techniques

Molecular Applications in Cytogenetics

Histocompatibility Laboratory Techniques and Applications

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Exam 5: The Complement System

Which of the following cell wall components can initiate the mannose binding lection pathway of complement activation?

Which of the following are TRUE regarding the alternate pathway of complement activation?

The C3 convertases for the classic and mannose binding lectin paths of complement activation are identical.

The abbreviation C3a in relation to complement gives what information?

The complement system is a group of proteins solely comprised of activators and substrates for the system.

When antigen binds to antibody, the ________ is (are) activated.

Hereditary angioedema is associated with a deficiency in________.

Describe the mechanism of acquired (nongenetic)complement deficiency.

Which of the following is TRUE regarding the C3 convertase in the classic complement pathway?

The activated components of complement are generally very stable to promote a long period of activity and shortened time of infection.

Which of the following is TRUE regarding paroxysmal nocturnal hemoglobinuria (PNH)?

Complement components are completely destroyed if a specimen is

When there is a complement deficiency, the CH50 increases.

All of the following conditions have been associated with deficiencies in complement regulatory proteins except

Complement fragments only attach to foreign cells, not host cells.

The cells with receptors for the anaphylotoxins are________.

What is (are)the consequence(s)of complement C5 being cleaved into C5a and C5b?

Which complement regulatory protein(s)below act(s)to prevent initial complement activation? (Check as many as apply.)

Name one complement regulatory protein that inhibits the membrane attack complex.

What Is Immunology

Overview of the Immune System

Immunoglobulins

Infection and Immunity: Hostparasite Relationships

Hypersensitivity

Immunologic Detection of Infectious Diseases

Autoimmune Diseases and Immunodeficiency Disorders

Transplant Immunology

Tumor Immunology

Clinical Applications of Flow Cytometry

Hybridization Techniques

Amplification Techniques

Molecular Applications in Cytogenetics

Histocompatibility Laboratory Techniques and Applications

Filters