Question 1

A constitutive mutation in the lac operon may be of several types. Name two types of constitutive mutations.

Accepted Answer

lacI - and lacOc

Question 2

What is alternative splicing?

Accepted Answer

Alternative splicing is a process that allows, through differential splicing of
pre -mRNA, a variety of different forms of mRNA. This process allows a number of different proteins to be formed from a single gene.

Question 3

What is an allosteric molecule?

Accepted Answer

one that can change shape, and therefore function, in interactions with other molecules

Question 4

The enzyme permease cleaves the linkage between glucose and galactose residues in lactose.

Accepted Answer

A) True 
 B)False

Question 5

Name two consensus sequences or modular DNA sequences that may be found upstream from coding regions of some eukaryotic genes.

Accepted Answer

TATA and C

Question 6

Which term most appropriately refers to a regulatory protein in prokaryotes?

Accepted Answer

A)  gyrase action 
B)  DNA binding protein 
C)  helicase activation 
D)  RNA processing 
E)  translation 
A)  gyrase action 
B)  DNA binding protein 
C)  helicase activation 
D)  RNA processing 
E)  translation

Question 7

Present an overview of prokaryotic regulation in terms of growth efficiency.

Accepted Answer

Genetic systems have evolved that allow

Question 8

In general, one could say that there are fewer levels of regulation possible in prokaryotes than in eukaryotes.

Accepted Answer

A) True 
 B)False

Question 9

Describe the general structure of a transcription factor.

Accepted Answer

Transcription factors are modu

Question 10

Regulation of RNA transport through the nuclear membrane is as common in prokaryotes as in eukaryotes.

Accepted Answer

A) True 
 B)False

Question 11

State whether the following statement is true or false; then give your reasoning: The terminating "hairpin" loop occurs in the trp operon when sufficient tryptophan is
present.

Accepted Answer

A) True 
 B)False

Question 12

Describe the positive control exerted by the catabolite activating protein (CAP). Include a description of catabolite repression.

Accepted Answer

Regarding regulation of the lac operon,

Question 13

Transcription in eukaryotes is generally influenced by enhancers, just as in prokaryotes.

Accepted Answer

A) True 
 B)False

Question 14

Describe three characteristics of enhancers.

Accepted Answer

position need not be fixed, or

Question 15

What is the function of the lacY gene in the lac operon?

Accepted Answer

The lacY gene codes for permea

Question 16

Regarding the lactose utilization system in E. coli, a gratuitous inducer is a molecule that is chemically analogous to lactose and induces the operon, but it is not a
substrate for the enzymes of the lac operon.

Accepted Answer

A) True 
 B)False

Question 17

Which of the following terms best characterizes catabolite repression associated with the lac operon in E. coli?

Accepted Answer

A)  inducible system 
B)  positive control 
C)  constitutive 
D)  repressible system 
E)  negative control 
A)  inducible system 
B)  positive control 
C)  constitutive 
D)  repressible system 
E)  negative control

Question 18

Under a system of negative control, genetic expression occurs unless some form of regulator shuts off such expression.

Accepted Answer

A) True 
 B)False

Question 19

What is the location of an enhancer in relation to the gene it affects?

Accepted Answer

The position of an enhancer ne

Question 20

Present a detailed description of the actions of the regulatory proteins in inducible and repressible enzyme systems.

Accepted Answer

Inducible system: The repressor is norma

Exam 15: Regulation of Gene Expression

A constitutive mutation in the lac operon may be of several types. Name two types of constitutive mutations.

What is alternative splicing?

What is an allosteric molecule?

The enzyme permease cleaves the linkage between glucose and galactose residues in lactose.

Name two consensus sequences or modular DNA sequences that may be found upstream from coding regions of some eukaryotic genes.

Which term most appropriately refers to a regulatory protein in prokaryotes?

Present an overview of prokaryotic regulation in terms of growth efficiency.

In general, one could say that there are fewer levels of regulation possible in prokaryotes than in eukaryotes.

Describe the general structure of a transcription factor.

Regulation of RNA transport through the nuclear membrane is as common in prokaryotes as in eukaryotes.

State whether the following statement is true or false; then give your reasoning: The terminating "hairpin" loop occurs in the trp operon when sufficient tryptophan is present.

Describe the positive control exerted by the catabolite activating protein (CAP). Include a description of catabolite repression.

Transcription in eukaryotes is generally influenced by enhancers, just as in prokaryotes.

Describe three characteristics of enhancers.

What is the function of the lacY gene in the lac operon?

Regarding the lactose utilization system in E. coli, a gratuitous inducer is a molecule that is chemically analogous to lactose and induces the operon, but it is not a substrate for the enzymes of the lac operon.

Which of the following terms best characterizes catabolite repression associated with the lac operon in E. coli?

Under a system of negative control, genetic expression occurs unless some form of regulator shuts off such expression.

What is the location of an enhancer in relation to the gene it affects?

Present a detailed description of the actions of the regulatory proteins in inducible and repressible enzyme systems.

Introduction to Genetics

Mitosis and Meiosis

Mendelian Genetics

Modifications of Mendelian Ratios

Sex Determination and Sex Chromosomes

Chromosome Mutations: Variation in Number and Arrangement

Linkage and Chromosome Mapping in Eukaryotes

Genetic Analysis and Mapping in Bacteria and Bactierophages

DNA Structure and Analysis

DNA Replication and Recombination

Chromosome Structure and Dna Sequence Organization

The Genetic Code and Transcription

Translation and Proteins

Gene Mutation, Dna Repair, and Transposition

The Genetics of Cancer

Recombinant Dna Technology

Genomics and Proteomics

Applications and Ethics of Genetic Engineering and Biotechnology

Developmental Genetics

Quantitative Genetics and Multifactorial Traits

Population and Evolutionary Genetics

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