Exam 5: Genomics, Proteomics, and Systems Biology

Sequencing the human genome revealed that 40% of the predicted proteins are related to proteins in a remarkably wide variety of eukaryotic organisms, such as yeast, Drosophila, and C. elegans. Considering that shared proteins suggest shared functions, what functions would you expect to be shared?

Why would approximately 40% of the predicted human proteins be related to proteins in simpler organisms?

To sequence the human genome, the International Human Genome Sequencing Consortium

A common characteristic of most bacterial genomes is that ~90% of the genome encodes for proteins.

The human genome contains approximately _______ base pairs.

The experimental inactivation of a gene by homologous recombination with an inactive mutant to assess function of the normal genes in intact organisms is often referred to as what type of experiment?

What percent of genes are similar between mice, rats, and humans?

The large-scale project called ENCODE used RNA-seq to characterize all RNAs in 147 human cell types. The surprise result from analysis of the data revealed that even though there is only 1% of the genome that encodes for protein, as much as _______% of the genome is actually transcribed.