Exam 15: Genetic Analysis of Cellular Processes

Fill in the blank. Temperature-sensitive mutations exhibit the mutation when grown at the restrictive temperature. They exhibit a wild-type phenotype when grown at a _____ temperature.

(Short Answer)

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Question 21

When Nüsslein-Volhard and Wieschaus conducted their genetic screen in Drosophila, they continued to find new genes of interest with increasing numbers of experiments, but the number of new mutations they discovered tailed off after about 2000 chromosomes had been tested.

(True/False)

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Question 22

Tryptophan is an essential amino acid that Neurospora crassa needs in order to be able to grow. The tryptophan biosynthetic pathway has three main steps by which the amino acid tryptophan is produced from chorismate. In an experiment, three N. crassa strains that were suspected of having defects in tryptophan synthesis were cultured on minimal medium (without tryptophan) and on minimum medium (plus tryptophan), with the following results. Which strain is defective in the tryptophan biosynthetic pathway? Minimal medium Minimal medium + tryptophan Strain 1 no growth growth Strain 2 no growth no growth Strain 3 growth growth

(Multiple Choice)

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Question 23

Which of the following is true of dominant loss-of-function mutations?

(Multiple Choice)

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Question 24

Components and analogs of the lac operon are used by researchers as experimental tools. Match the molecule with its activity. -allolactose

(Multiple Choice)

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Question 25

Which of the following is an advantage of a genome-wide mutagenesis screen compared to a random mutagenesis screen?

(Multiple Choice)

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Question 26

Nüsslein-Volhard and Wieschaus used Drosophila melanogaster as a model organism in genetic screens to examine developmental biology. Why was Drosophila a good model organism for this study? Please select all that apply.

(Multiple Choice)

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Question 27

Arginine is synthesized in a pathway involving several enzymes and biosynthetic intermediates. Five Neurospora crassa strains were cultured on minimal media containing various additives, and the results are shown. Match each N. crassa strain with its description. $Arginine is synthesized in a pathway involving several enzymes and biosynthetic intermediates. Five Neurospora crassa strains were cultured on minimal media containing various additives, and the results are shown. Match each N. crassa strain with its description. \begin{array} { | c | c | c | c | c | } \hline & \text { glutamate } & \text { ornithine } & \text { citrulline } & \text { arginine } \\ \hline \text { Strain A } & \text { growth } & \text { growth } & \text { growth } & \text { growth } \\ \hline \text { Strain B } & \text { no growth } & \text { no growth } & \text { growth } & \text { growth } \\ \hline \text { Strain C } & \text { no growth } & \text { no growth } & \text { no growth } & \text { no growth } \\ \hline \text { Strain D } & \text { no growth } & \text { no growth } & \text { no growth } & \text { growth } \\ \hline \text { Strain E } & \text { no growth } & \text { growth } & \text { growth } & \text { growth } \\ \hline \end{array}$ glutamate ornithine citrulline arginine Strain A growth growth growth growth Strain B no growth no growth growth growth Strain C no growth no growth no growth no growth Strain D no growth no growth no growth growth Strain E no growth growth growth growth

(Essay)

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Question 28

Showing 21 - 28 of 28

Fill in the blank. Temperature-sensitive mutations exhibit the mutation when grown at the restrictive temperature. They exhibit a wild-type phenotype when grown at a _____ temperature.

When Nüsslein-Volhard and Wieschaus conducted their genetic screen in Drosophila, they continued to find new genes of interest with increasing numbers of experiments, but the number of new mutations they discovered tailed off after about 2000 chromosomes had been tested.

Which of the following is true of dominant loss-of-function mutations?

Components and analogs of the lac operon are used by researchers as experimental tools. Match the molecule with its activity. -allolactose

Which of the following is an advantage of a genome-wide mutagenesis screen compared to a random mutagenesis screen?

Nüsslein-Volhard and Wieschaus used Drosophila melanogaster as a model organism in genetic screens to examine developmental biology. Why was Drosophila a good model organism for this study? Please select all that apply.

Darwins Finches: Evolution, Genomes, and Genes

The Central Dogma of Molecular Biology

Genome Structure, Organization, and Variation

Descent With Modification: Dna Replication and Mutation

The Inheritance of Single Gene Traits

The Cellular Basis for Mendelian Genetics

X-Linked Genes and Sex Chromosomes

The Inheritance of Multiple Genes

The Locations of Genes on Chromosomes: Linkage and Genetic Maps

Human Genetic Mapping, Genome Wide Association Studies, and Complex Traits

Exchange and Evolution

Transcription: Reading and Expressing Genes

Translation: From Nucleic Acids to Amino Acids

Networks of Gene Regulation

The Genetics of Populations

Metagenomes: Genome Analysis of Communities

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