Exam 10: Human Genetic Mapping, Genome Wide Association Studies, and Complex Traits

Which of the following can a genome-wide association study not do?

Which of the following pieces of evidence suggest that genetic factors have an influence on height? Please select all that apply.

Microarrays can be used to examine gene expression and also to conduct genome-wide association studies (GWAS). Which of the following are true about these microarrays? Please select all that apply.

For a locus to be classed as polymorphic, the second most common polymorphism must be found at least 10% of the time.

Why are regions between genes (intergenic regions) often chosen as mapping markers in genome-wide association studies? Please select all that apply.

Match the type of DNA sequence variation with its name -Additions or deletions of pieces of DNA

People with a genetic disease that is common in one population but uncommon in other populations usually have the same haplotype.

Match the type of DNA sequence variation with its name -Changes at one nucleotide

What does linkage disequilibrium refer to?

The On-line Mendelian Inheritance in Man (OMIM) database is an important resource for human genetics. Most of the content in OMIM relates to monogenic diseases. Which of the following conditions are not generally thought to be monogenic? Please select all that apply.

Consider two genes, A and B, with alleles A & a, and B & b. In a population, 60% of gametes have A and 40% have a; 90% of gametes have B and 10% have b. In an experiment, 625 gametes are AB, 408 are aB, 72 are Ab, and 45 ab. Which of the following statements are true about genes A and B in this population? Please select all that apply.

What term is used for the fraction of phenotypic variation that can be attributed to genetic differences among individuals?

Cystic fibrosis (CF) is a common disease in European populations. Most individuals with the disease have the same mutation in the CF gene. What does this suggest about the evolution of CF?

Fill in the blank. If all individuals in a population carry the same allele for a particular gene, then the allele is said to be ____ in that population

Match the type of DNA sequence variation with its name -Changes in the number of copies of a small sequence

Exome sequencing is powerful technique that has been used to identify genes linked to a number of rare genetic conditions. Which of the following is a disadvantage of exome sequencing?

Match the type of DNA sequence variation with its name -Changes occurring only in a small number of related individuals

Match the missing words in the following phrase. In [A]-Wide Association Studies, researchers identify lots of [B] with ([C]) and without ([D]) a [E]. Genomes are compared and any [F] that are consistently associated with the trait are identified.

Which if the following statements about human evolution and diversity is true?

What molecular genetics term is used for making a connection between the gene as it relates to a phenotype and the gene in terms of its DNA sequence?