Exam 10: Human Genetic Mapping, Genome Wide Association Studies, and Complex Traits

What does a Manhattan plot show?

Genetic analysis in model organisms such as Drosophila cannot easily be replicated in humans. Which of the following factors are true of Drosophila but not humans? Please select all that apply.

Complex traits are affected by multiple genes. Individuals with the same phenotype for a complex trait will also share the same genotype.

Match the missing words in the following phrase. Analysis of complex traits requires [A] analysis to determine how much of the [B] in a trait is attributable to genetics. When measurements are taken of a [C] in a population, e. g., height, the results form a [D]. Many of these follow [E] shapes but this is not always the case - for example, flies with red or white eyes fall into two [F] categories.

What term is used for a block of alleles that is inherited together?

Fill in the blank. Migrating humans often lived in small groups, and by chance the genetic diversity in these groups may have been different to the diversity in the wider population. This phenomenon is known as the ____ ___

What term is used for genes that affect the phenotype of a complex trait?

Nine features of a GWAS array are shown, as well as the hybridization results from an experiment (hybridized = red, not hybridized = white). What is the genotype of the person being investigated? ..GCTAGTCCG.. ..AAATATCAGT.. ..CCTGGGCTAG.. ..GCTACTCCG.. ..AAATTTCAGT.. ..CCTGGCCTAG.. ..GCTAATCCG.. ..CCTGGACTAG.. ..CCTGGTCTAG..