Exam 4: Descent With Modification: Dna Replication and Mutation

Which of these are found at a replication fork? Please select all that apply.

Where is the next nucleotide added to the growing chain during DNA replication?

Match the missing words in the following phrase. [A] relieves supercoils ahead of the replication fork, then [B] unwinds the double helix. [C] synthesizes DNA, and [D] joins discontinuous pieces of DNA together.

The Meselson-Stahl experiment used DNA containing ¹⁴N and ¹⁵N to show that DNA replication is semi-conservative. If replication had been conservative (i.e., one double helix formed of 'old' DNA, and one completely new double helix), what would have been the expected outcome of the experiment after one round of replication?

Match the missing words in the following phrase: Somatic mutations can give rise to cancer. Genes that encode proteins that stop cells dividing uncontrollably are called [A]. Mutations that [B] the amount or activity of the resultant proteins can lead to cancer. Genes encoding proteins that promote cell division are called [C]. Mutations that [D] the amount or activity of the resultant proteins can lead to cancer.

During DNA replication, the leading strand of the separated double helix is synthesized using continuous replication. The lagging strand is synthesized using discontinuous replication.

Match the missing words in the following phrase. Darwin's principle of 'descent with modification' describes the balance between fitness and [A]. Natural [B] are acted on by [C], favoring individuals with the best [D] for that particular environment.

Using the following DNA as template, the sequence of the newly-synthesized strand is 5'______________3' Template DNA: 5'ACGTAGCACATGACT3'