Question 1

The polymerase chain reaction has revolutionized genetics because

Accepted Answer

A) it is capable of making virtually unlimited copies of DNA for study. 
B) it is capable of making copies of DNA with very little starting material. 
C) it is capable of making large numbers of DNA copies very quickly. 
D) All of these 
E) A and B only 
A) it is capable of making virtually unlimited copies of DNA for study. 
B) it is capable of making copies of DNA with very little starting material. 
C) it is capable of making large numbers of DNA copies very quickly. 
D) All of these 
E) A and B only D

Question 2

Linkage disequilibrium refers to a condition in which

Accepted Answer

A) a set of SNPs recombine often. 
B) a set of haplotypes recombine often. 
C) a set of specific alleles of two or more genes tend to appear together. 
D) a set of specific alleles of two or more genes only rarely appear together. 
E) a haplotype block rearranges every generation. 
A) a set of SNPs recombine often. 
B) a set of haplotypes recombine often. 
C) a set of specific alleles of two or more genes tend to appear together. 
D) a set of specific alleles of two or more genes only rarely appear together. 
E) a haplotype block rearranges every generation. C

Question 3

Why does the transcriptome differ within an organism's cell types?

Accepted Answer

All the genes of a multicellular organism are not expressed in every cell type.The various cell types express different subsets of the genome,and the makeup of the transcripts (the transcriptome)differs depending on which genes are expressed at a given time.

Question 4

The ________ gene is responsible for removing many of the drugs introduced into the human body.

Accepted Answer

A) HAR-1 
B) CYP2D6 
C) ASPM 
D) FOXP2 
E) BRCA1 
A) HAR-1 
B) CYP2D6 
C) ASPM 
D) FOXP2 
E) BRCA1

Question 5

Metagenomic analysis involves

Accepted Answer

A) culturing microbes isolated from the environment. 
B) extracting DNA from cultured microbes. 
C) analyzing DNA from environmental samples. 
D) sequencing cloned DNA individually. 
E) determining culture conditions for different microbes. 
A) culturing microbes isolated from the environment. 
B) extracting DNA from cultured microbes. 
C) analyzing DNA from environmental samples. 
D) sequencing cloned DNA individually. 
E) determining culture conditions for different microbes.

Question 6

Which of the following is an archaean that has been identified in the human gut?

Accepted Answer

A) Escherichia coli 
B) Enterobacter aerogenes 
C) Bifidobacterium longum 
D) Methanobrevibacter smithii 
E) Caenorhabditis elegans 
A) Escherichia coli 
B) Enterobacter aerogenes 
C) Bifidobacterium longum 
D) Methanobrevibacter smithii 
E) Caenorhabditis elegans

Question 7

Cy3 and Cy5 are radioactive tags used in microarrays.

Accepted Answer

A) True 
 B)False

Question 8

The FOXP2 protein appears to play a critical role in brain size regulation.

Accepted Answer

A) True 
 B)False

Question 9

Which of the following triggers the RNAi pathway?

Accepted Answer

A) mRNA 
B) rRNA 
C) tRNA 
D) shRNA 
E) snRNA 
A) mRNA 
B) rRNA 
C) tRNA 
D) shRNA 
E) snRNA

Question 10

The subfield of genomics that deals with gene expression and interaction is

Accepted Answer

A) comparative genomics. 
B) functional genomics. 
C) structural genomics. 
D) hypothetical genomics. 
E) expression genomics. 
A) comparative genomics. 
B) functional genomics. 
C) structural genomics. 
D) hypothetical genomics. 
E) expression genomics.

Question 11

Why are two selectable markers present in the target vector used for making mouse gene knockouts?

Accepted Answer

Two selectable markers are used for maki

Question 12

What is the difference between a "knockout" and a "knockdown" of a gene?

Accepted Answer

Both terms refer to the alteration in th

Question 13

Calculate the number of copies that would be produced from a single starting molecule after 10 rounds of PCR.

Accepted Answer

Ten cycles would pro

Question 14

Both strands of the short,double-stranded regulatory RNA molecules are required by the Slicer protein in order to target the complementary RNA for degradation.

Accepted Answer

A) True 
 B)False

Question 15

BLAST is a software that searches for similarities between DNA sequences only.

Accepted Answer

A) True 
 B)False

Question 16

How do we know that some of the microbes in our gut are beneficial to us?

Accepted Answer

Individuals lacking normal int

Question 17

A transgene is a

Accepted Answer

A) hybrid gene. 
B) gene that contains no introns. 
C) bacterial gene that is found in mammalian cells. 
D) human gene of viral origin. 
E) gene introduced into an organism by artificial means. 
A) hybrid gene. 
B) gene that contains no introns. 
C) bacterial gene that is found in mammalian cells. 
D) human gene of viral origin. 
E) gene introduced into an organism by artificial means.

Question 18

A microbiome consists of

Accepted Answer

A) all the microorganisms on Earth. 
B) the community of microorganisms in a particular environment. 
C) the transcriptome from a particular microorganism under different environments. 
D) the proteome from a particular microorganism under different environments. 
E) the proteome from different microorganisms in a particular environment. 
A) all the microorganisms on Earth. 
B) the community of microorganisms in a particular environment. 
C) the transcriptome from a particular microorganism under different environments. 
D) the proteome from a particular microorganism under different environments. 
E) the proteome from different microorganisms in a particular environment.

Question 19

"Knockout" mutants have had the activities of certain genes eliminated,which can aid the researchers in determining the effects of those genes on physiology,development,and other functions.

Accepted Answer

A) True 
 B)False

Question 20

Bioinformatics is a relatively new field that combines elements of genomics with computer science and mathematics.

Accepted Answer

A) True 
 B)False

Exam 9: Functional and Comparative Genomics

The polymerase chain reaction has revolutionized genetics because

Linkage disequilibrium refers to a condition in which

Why does the transcriptome differ within an organism's cell types?

The ________ gene is responsible for removing many of the drugs introduced into the human body.

Metagenomic analysis involves

Which of the following is an archaean that has been identified in the human gut?

Cy3 and Cy5 are radioactive tags used in microarrays.

The FOXP2 protein appears to play a critical role in brain size regulation.

Which of the following triggers the RNAi pathway?

The subfield of genomics that deals with gene expression and interaction is

Why are two selectable markers present in the target vector used for making mouse gene knockouts?

What is the difference between a "knockout" and a "knockdown" of a gene?

Calculate the number of copies that would be produced from a single starting molecule after 10 rounds of PCR.

Both strands of the short,double-stranded regulatory RNA molecules are required by the Slicer protein in order to target the complementary RNA for degradation.

BLAST is a software that searches for similarities between DNA sequences only.

How do we know that some of the microbes in our gut are beneficial to us?

A transgene is a

A microbiome consists of

"Knockout" mutants have had the activities of certain genes eliminated,which can aid the researchers in determining the effects of those genes on physiology,development,and other functions.

Bioinformatics is a relatively new field that combines elements of genomics with computer science and mathematics.

Genetics: An Introduction

DNA: The Genetic Material

DNA Replication

Gene Function

Gene Expression: Transcription

Gene Expression: Translation

Dna Mutation, DNA Repair, and Transposable Elements

Genomics: The Mapping and Sequencing of Genomes

Recombinant DNA Technology

Mendelian Genetics

Chromosomal Basis of Inheritance

Extensions of and Deviations From Mendelian Genetic Principles

Genetic Mapping in Eukaryotes

Genetics of Bacteria and Bacteriophages

Variations in Chromosome Structure and Number

Regulation of Gene Expression in Bacteria and Bacteriophages

Regulation of Gene Expression in Eukaryotes

Genetic Analysis of Development

Genetics of Cancer

Population Genetics

Quantitative Genetics

Molecular Evolution

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