Question 1

Mutation of the BRCA protein can lead to

Accepted Answer

A)  breast cancer. 
B)  lymphoma. 
C)  arthritis. 
D)  bone tumors. 
A)  breast cancer. 
B)  lymphoma. 
C)  arthritis. 
D)  bone tumors. A

Question 2

The best definition for DNA replication is when a cell copies its __________ genome and is __________ cell division.

Accepted Answer

A)  entire; a required element of 
B)  partial; a required element of 
C)  entire; not required for 
D)  partial; not required for 
A)  entire; a required element of 
B)  partial; a required element of 
C)  entire; not required for 
D)  partial; not required for A

Question 3

What is a possible outcome when UV light reacts with riboflavin or tryptophan?

Accepted Answer

A)  methylated riboflavin 
B)  reactive oxygen species 
C)  spontaneous deglycosylation 
D)  production of an abasic site 
A)  methylated riboflavin 
B)  reactive oxygen species 
C)  spontaneous deglycosylation 
D)  production of an abasic site B

Question 4

Cytosine can be deaminated because it has a free __________ that can be removed.

Accepted Answer

A)  keto group 
B)  amine 
C)  amide group 
D)  ester group 
A)  keto group 
B)  amine 
C)  amide group 
D)  ester group

Question 5

If one parent has Lynch syndrome but the other does not,what is the likelihood that the child will also have Lynch syndrome?

Accepted Answer

A)  10% 
B)  25% 
C)  50% 
D)  100% 
A)  10% 
B)  25% 
C)  50% 
D)  100%

Question 6

What is the function of telomerase in termination of DNA synthesis?

Accepted Answer

A)  remove the telomeres 
B)  reverse transcription of the telomeres 
C)  bind to single-strand DNA to prevent refolding 
D)  shorten the DNA strand after each replication 
A)  remove the telomeres 
B)  reverse transcription of the telomeres 
C)  bind to single-strand DNA to prevent refolding 
D)  shorten the DNA strand after each replication

Question 7

What would a possible outcome be if no primer could be added at the end of a linear chromosome during replication?

Accepted Answer

A)  DNA synthesis would restart on the same strand. 
B)  DNA synthesis would be enhanced. 
C)  The chromosome would be shortened every subsequent replication. 
D)  The chromosome would be elongated every subsequent replication. 
A)  DNA synthesis would restart on the same strand. 
B)  DNA synthesis would be enhanced. 
C)  The chromosome would be shortened every subsequent replication. 
D)  The chromosome would be elongated every subsequent replication.

Question 8

Which prokaryotic polymerase is mainly responsible for DNA proofreading?

Accepted Answer

A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol   
A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol

Question 9

Explain the trombone model of DNA synthesis.

Accepted Answer

The trombone model of DNA synthesis at t

Question 10

Which of the following is the most common type of DNA damage?

Accepted Answer

A)  deamination of cytosine 
B)  deamination of uracil 
C)  methylation of adenine 
D)  methylation of tyrosine 
A)  deamination of cytosine 
B)  deamination of uracil 
C)  methylation of adenine 
D)  methylation of tyrosine

Question 11

A replication fork is necessary because it allows

Accepted Answer

A)  for DNA replication to start on a single strand. 
B)  for DNA replication to start on the double strand. 
C)  DNA to break into half to start replication. 
D)  DNA to unwind completely to start replication. 
A)  for DNA replication to start on a single strand. 
B)  for DNA replication to start on the double strand. 
C)  DNA to break into half to start replication. 
D)  DNA to unwind completely to start replication.

Question 12

The DNA alkylation of guanine is possible because the __________ of guanine is __________ and reacts rapidly with __________ alkylating agents.

Accepted Answer

A)  N-7; nucleophilic; electrophilic 
B)  N-5; nucleophilic; electrophilic 
C)  N-7; electrophilic; nucleophilic 
D)  N-5; electrophilic; nucleophilic 
A)  N-7; nucleophilic; electrophilic 
B)  N-5; nucleophilic; electrophilic 
C)  N-7; electrophilic; nucleophilic 
D)  N-5; electrophilic; nucleophilic

Question 13

What role does PARP1 have in repairing a single-strand DNA break?

Accepted Answer

A)  recognizes the break 
B)  removes the methyl group from guanine 
C)  replaces the mismatched pair 
D)  absorbs light to become excited 
A)  recognizes the break 
B)  removes the methyl group from guanine 
C)  replaces the mismatched pair 
D)  absorbs light to become excited

Question 14

A Holliday junction can best be defined as a region of

Accepted Answer

A)  quadruplex DNA. 
B)  duplex DNA. 
C)  DNA damage. 
D)  DNA pyrimidine duplexes. 
A)  quadruplex DNA. 
B)  duplex DNA. 
C)  DNA damage. 
D)  DNA pyrimidine duplexes.

Question 15

AZT is such a good HIV drug because it

Accepted Answer

A)  prevents new DNA from being replicated. 
B)  prevents HIV from binding to the cell. 
C)  allows DNA to repair itself after viral DNA is added. 
D)  allows DNA to be replicated at a slower rate. 
A)  prevents new DNA from being replicated. 
B)  prevents HIV from binding to the cell. 
C)  allows DNA to repair itself after viral DNA is added. 
D)  allows DNA to be replicated at a slower rate.

Question 16

Tus-Ter terminates DNA synthesis by

Accepted Answer

A)  breaking the single-strand DNA and preventing further synthesis. 
B)  forcing the primase to dissociate. 
C)  blocking the opening of helicase. 
D)  methylating the DNA strand. 
A)  breaking the single-strand DNA and preventing further synthesis. 
B)  forcing the primase to dissociate. 
C)  blocking the opening of helicase. 
D)  methylating the DNA strand.

Question 17

DNA polymerase does not make mismatched base pairs because

Accepted Answer

A)  there are no hydrogen bonds that line up between the mismatches. 
B)  the active site does not fit mismatches well. 
C)  the mismatched pairs make covalent bonds instead of hydrogen bonds. 
D)  the DNA primer does not allow for mismatched pairs. 
A)  there are no hydrogen bonds that line up between the mismatches. 
B)  the active site does not fit mismatches well. 
C)  the mismatched pairs make covalent bonds instead of hydrogen bonds. 
D)  the DNA primer does not allow for mismatched pairs.

Question 18

Compare the two different outcomes of cytosine deamination as replication proceeds.

Accepted Answer

@#IMG-DLM&_TB6697_00 As shown in Figure 20.34,ther

Question 19

Which of the following is a specialized direct DNA repair process?

Accepted Answer

A)  DNA photolyase system 
B)  nucleotide excision repair 
C)  base excision repair 
D)  DNA mismatch repair 
A)  DNA photolyase system 
B)  nucleotide excision repair 
C)  base excision repair 
D)  DNA mismatch repair

Question 20

Describe the differences between Pol   ,Pol   
,and Pol   
in eukaryotic organisms.

Accepted Answer

Pol @#LAT-DLM& has an extremely high processivity

Exam 20: Dna Replication, repair, and Recombination

Mutation of the BRCA protein can lead to

The best definition for DNA replication is when a cell copies its __________ genome and is __________ cell division.

What is a possible outcome when UV light reacts with riboflavin or tryptophan?

Cytosine can be deaminated because it has a free __________ that can be removed.

If one parent has Lynch syndrome but the other does not,what is the likelihood that the child will also have Lynch syndrome?

What is the function of telomerase in termination of DNA synthesis?

What would a possible outcome be if no primer could be added at the end of a linear chromosome during replication?

Which prokaryotic polymerase is mainly responsible for DNA proofreading?

Explain the trombone model of DNA synthesis.

Which of the following is the most common type of DNA damage?

A replication fork is necessary because it allows

The DNA alkylation of guanine is possible because the __________ of guanine is __________ and reacts rapidly with __________ alkylating agents.

What role does PARP1 have in repairing a single-strand DNA break?

A Holliday junction can best be defined as a region of

AZT is such a good HIV drug because it

Tus-Ter terminates DNA synthesis by

DNA polymerase does not make mismatched base pairs because

Compare the two different outcomes of cytosine deamination as replication proceeds.

Which of the following is a specialized direct DNA repair process?

Describe the differences between Pol ,Pol ,and Pol in eukaryotic organisms.

Principles of Biochemistry

Physical Biochemistry: Energy Conversion,water,and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

Rna Synthesis, processing, and Gene Silencing

Protein Synthesis, posttranslational Modification, and Transport

Gene Regulation

Filters

The best definition for DNA replication is when a cell copies its genome and is cell division.

The DNA alkylation of guanine is possible because the of guanine is and reacts rapidly with __ alkylating agents.