Question 1

Which of the following would cause a genetic mutation?

Accepted Answer

A)  DNA makes too many copies in the cell. 
B)  DNA synthesis does not occur. 
C)  DNA damage is not corrected. 
D)  Death of a cell occurs. 
A)  DNA makes too many copies in the cell. 
B)  DNA synthesis does not occur. 
C)  DNA damage is not corrected. 
D)  Death of a cell occurs.

Question 2

MGMT is called the suicide enzyme because its active site permanently becomes

Accepted Answer

A)  phosphorylated. 
B)  methylated. 
C)  protonated. 
D)  ionized. 
A)  phosphorylated. 
B)  methylated. 
C)  protonated. 
D)  ionized.

Question 3

The definition of a transposon is a segment of

Accepted Answer

A)  DNA that can move from one region to another. 
B)  RNA that can move from one region to another. 
C)  DNA that is easily transcribed. 
D)  DNA that is in need of repair. 
A)  DNA that can move from one region to another. 
B)  RNA that can move from one region to another. 
C)  DNA that is easily transcribed. 
D)  DNA that is in need of repair.

Question 4

What are the mechanisms for excision nucleotide repairs in eukaryotes?

Accepted Answer

A)  global genomic and mismatch 
B)  global genomic and base excision 
C)  transcription-coupled and partial genomic 
D)  transcription-coupled and global genomic 
A)  global genomic and mismatch 
B)  global genomic and base excision 
C)  transcription-coupled and partial genomic 
D)  transcription-coupled and global genomic

Question 5

Describe the experiment that demonstrated that complete unwinding of the chromosome does not occur.

Accepted Answer

John Cairnes grew E.coli in the presence

Question 6

Describe the mechanism of retroviral DNA integration into a eukaryotic genome.

Accepted Answer

HIV integration into the host cell genom

Question 7

What is the function of the MutS-MutL-MutH protein complex?

Accepted Answer

A)  base excision 
B)  mismatch repair 
C)  DNA adenylation 
D)  DNA methylation 
A)  base excision 
B)  mismatch repair 
C)  DNA adenylation 
D)  DNA methylation

Question 8

HIVRT is closely related to which DNA polymerase?

Accepted Answer

A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol IV 
A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol IV

Question 9

All DNA is synthesized in which direction?

Accepted Answer

A)    
B)    
C)    
D)    
A)    
B)    
C)    
D)

Question 10

Describe the differences among Pol I,Pol II,and Pol III in prokaryotic organisms.

Accepted Answer

Pol III is the main polymerizing enzyme

Question 11

The   -hydroxyl group used to initiate DNA synthesis comes from

Accepted Answer

A)  a RNA primer. 
B)  the magnesium ion. 
C)  uracils, always. 
D)  amino acids, always. 
A)  a RNA primer. 
B)  the magnesium ion. 
C)  uracils, always. 
D)  amino acids, always.

Question 12

Homologous recombination can only be used in late S phase or G2 phase because it

Accepted Answer

A)  requires the presence of an intact sister chromatid as a template. 
B)  does not require the presence of a homologous template. 
C)  requires the cell to be in cell division. 
D)  requires the cell to be in the resting phase. 
A)  requires the presence of an intact sister chromatid as a template. 
B)  does not require the presence of a homologous template. 
C)  requires the cell to be in cell division. 
D)  requires the cell to be in the resting phase.

Question 13

How is Dam methylase able to be a control mechanism for DNA replication initiation?

Accepted Answer

Methylation by Dam methylase is used to

Question 14

Contrast missense mutations,nonsense mutations,and silent mutations.

Accepted Answer

It takes three nucleotide bases in DNA t

Question 15

Using the figure below,explain the replication and termination of DNA synthesis in E.coli.

Accepted Answer

DNA synthesis proceeds bidirectionally u

Question 16

How is an individual with Lynch syndrome at higher risk for cancer?

Accepted Answer

Lynch syndrome is caused by autosomal do

Question 17

What role do BRCA1 and BRCA2 play in DNA repair?

Accepted Answer

A)  find the double-strand break 
B)  assist with strand invasion 
C)  repair pyrimidine dimers 
D)  synthesize new DNA bases 
A)  find the double-strand break 
B)  assist with strand invasion 
C)  repair pyrimidine dimers 
D)  synthesize new DNA bases

Question 18

What would happen first if a cell was no longer able to produce DnaA?

Accepted Answer

A)  DnaC would not be able to bind to DnaB. 
B)  DnaB would not bind to primase. 
C)  The genome would not be unwound. 
D)  Pol III would not be able to bind to the DNA. 
A)  DnaC would not be able to bind to DnaB. 
B)  DnaB would not bind to primase. 
C)  The genome would not be unwound. 
D)  Pol III would not be able to bind to the DNA.

Question 19

Most cancers are caused by which kind of DNA mutation?

Accepted Answer

A)  base substitution 
B)  abasic site 
C)  somatic 
D)  nucleotide deletions 
A)  base substitution 
B)  abasic site 
C)  somatic 
D)  nucleotide deletions

Question 20

How can DNA strands be synthesized using bidirectional replication?

Accepted Answer

A)  They are not synthesized simultaneously. 
B)  One strand is synthesized   , whereas the other is   . 
C)  They are synthesized through Okazaki fragments. 
D)  They are synthesized using RNA polymerases. 
A)  They are not synthesized simultaneously. 
B)  One strand is synthesized   , whereas the other is   . 
C)  They are synthesized through Okazaki fragments. 
D)  They are synthesized using RNA polymerases.

Exam 20: Dna Replication, repair, and Recombination

Which of the following would cause a genetic mutation?

MGMT is called the suicide enzyme because its active site permanently becomes

The definition of a transposon is a segment of

What are the mechanisms for excision nucleotide repairs in eukaryotes?

Describe the experiment that demonstrated that complete unwinding of the chromosome does not occur.

Describe the mechanism of retroviral DNA integration into a eukaryotic genome.

What is the function of the MutS-MutL-MutH protein complex?

HIVRT is closely related to which DNA polymerase?

All DNA is synthesized in which direction?

Describe the differences among Pol I,Pol II,and Pol III in prokaryotic organisms.

The -hydroxyl group used to initiate DNA synthesis comes from

Homologous recombination can only be used in late S phase or G2 phase because it

How is Dam methylase able to be a control mechanism for DNA replication initiation?

Contrast missense mutations,nonsense mutations,and silent mutations.

Using the figure below,explain the replication and termination of DNA synthesis in E.coli.

How is an individual with Lynch syndrome at higher risk for cancer?

What role do BRCA1 and BRCA2 play in DNA repair?

What would happen first if a cell was no longer able to produce DnaA?

Most cancers are caused by which kind of DNA mutation?

How can DNA strands be synthesized using bidirectional replication?

Principles of Biochemistry

Physical Biochemistry: Energy Conversion,water,and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

Rna Synthesis, processing, and Gene Silencing

Protein Synthesis, posttranslational Modification, and Transport

Gene Regulation

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