Exam 14: Autoimmunity

A 10-year-old girl was brought in to her physician's office because she had been complaining that she was thirsty and had to go to the bathroom all the time.She had lost 15 pounds over the last 6 months and was more irritable than usual,especially after meals.The girl's fasting blood glucose was 575 mg/dL,her C-peptide was 0.5 ng/mL,and she had autoantibodies against glutamic acid decarboxylase and insulin.This girl has:

Which of the following are characteristic of cold autoimmune hemolytic anemia?

A disease characterized by hypoactivity of the thyroid with weight gain and a sluggish metabolism due to destruction of thyroglobulin best describes:

Systemic lupus erythematosus can be characterized by all of the following EXCEPT:

An autoimmune disease characterized by pain and progressive destruction of the joints,weight loss,morning stiffness,and presence of an antibody directed against IgG best describes:

Antibodies directed against thyroglobulin represent a significant finding in which of the following autoimmune diseases?

Which of the following would be an indicator of systemic lupus?

In the slide agglutination for lupus,which of the following is detected?

A 25-year-old female sees her physician because of swelling in the joints of her hands and generally feeling tired and run down.A slide agglutination test for antibody directed against IgG is positive.What is the most likely cause of her symptoms?

A 54-year-old woman presents to her optometrist complaining that she has been having difficulty focusing on objects,both near and far.Her vision problems are getting progressively worse.She also thinks that her eyelids are drooping and she is thinking of getting plastic surgery to "put them back up." The optometrist cannot find a good reason for her vision problems but is able to fit her with glasses and recommends that she see a rheumatologist.The rheumatologist sends the women's blood for autoantibody testing,and the laboratory professionals report that the woman has autoantibodies against the acetylcholine receptor.This woman has:

A 35-year-old female experiences difficulty in walking,and her hands and feet are numb from time to time.Suspecting a disease involving the central nervous system,her physician orders an MRI.The MRI reveals lesions on the myelin sheath.What is the most likely disease?

Which of the following lab findings would be most likely to indicate multiple sclerosis?

Reasons for autoimmunity may include all of the following EXCEPT:

In which one of the following autoimmune diseases are antibodies to acetylcholine receptors produced,thereby blocking the signal to muscles?

The "CREST" variant of which disease is associated with the presence of an anticentromere antibody?

Homogeneous staining of the nucleus in an ANA test indicates:

A 56-year-old woman presents to her physician complaining of weight gain and joint problems.She is increasingly having difficulty walking up stairs and manipulating her fingers.Fingers in both hands as well as knees on both legs are equally painful and stiff.The symptoms have been progressing over the last 6 months.Rheumatoid factor is elevated,and antinuclear antibodies are not detected.Complement levels in her joints are less than the levels in her serum.This woman has:

A 40-year-old woman presents with a lemon-yellow,waxy pallor and a red,beefy tongue.She is extremely fatigued and is having difficulty getting up in the morning and getting through the day.Antiparietal cell antibodies are found in her serum.This woman has:

A 33-year-old female presents with red and irritated eyes for the last month.Discharge from the eyes is not apparent.She also has had recurrent low-grade fever and a rash on her chest and legs.Her joints have been achy for the last few months,and her mouth has been so dry it is often difficult to swallow food.Antinuclear antibody testing is performed,and a speckled pattern is observed on hep-2 cells.Follow-up testing reveals the presence of autoantibodies against SS-A and SS-B.This woman has:

The fluorescent antinuclear antibody test for lupus is an example of which of the following?