Exam 21: The Hla System

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Recipient lymphocytotoxic HLA-antibody to donor antigens is associated with:

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Patients who have been presensitized to HLA antigens have a much higher graft survival rate in liver transplantation than nonsensitized patients.

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What kidney transplant strategy is satisfied through matching of the donor and recipient antigens?

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Between which two loci are recombination (crossing over) most likely to occur?

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What is the purpose of washing the cells after the initial cell-serum incubation in the Amos-modified antibody screen procedure?

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Which MHC region encodes for complement proteins?

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The majority of cross-reactive alloantibodies detect HLA specificities of allelic molecules coded by the same locus.

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HLA testing is useful in what other area of study?

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The MHC class I region encodes for all of the following genes except:

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What is the main purpose of crossmatching before transplantation?

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In testing for the HLA-D antigens (DR, DP, DQ, etc.)___________ typing cells of each phenotype are set up in an MLR as against the test cells.

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The majority of HLA alloantibodies are ___________immunoglobulins.

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Why are T cells unacceptable for cytotoxicity testing using fluorescent labeling?

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Why is histocompatibility testing negated in both lung and heart transplants?

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The surface marker, or antigen, detected in histocompatibility testing of a single individual is referred to as HLA:

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How are monoclonal HLA antibodies (MoAbs) produced?

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A double-lung transplant is indicated in which of the following disorders?

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The primary indication for pancreas transplantation is:

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The HLA-A locus antigens A2, A23, A24, and A28 make up the:

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Which of the following is an example of linkage disequilibrium?

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