Question 1

All of the following are functions performed by the complement system except:

Accepted Answer

A)  direct lysis of bacteria. 
B)  promotion of phagocytosis. 
C)  decreased vascular permeability. 
D)  smooth muscle contraction. 
A)  direct lysis of bacteria. 
B)  promotion of phagocytosis. 
C)  decreased vascular permeability. 
D)  smooth muscle contraction. C

Question 2

Which is a characteristic of natural killer (NK) cells?

Accepted Answer

A)  They bind to and lyse antibody-coated cells in ADCC. 
B)  They require the presence of MHC to respond to antigen. 
C)  They produce antibody to act on foreign antigens. 
D)  They possess the TCR on their membrane surface. 
A)  They bind to and lyse antibody-coated cells in ADCC. 
B)  They require the presence of MHC to respond to antigen. 
C)  They produce antibody to act on foreign antigens. 
D)  They possess the TCR on their membrane surface. A

Question 3

Extravascular hemolysis occurs when red blood cells are coated with antibody; what organ sequesters these cells?

Accepted Answer

A)  Thymus 
B)  Reticuloendothelial system 
C)  Bone marrow 
D)  All of the above 
A)  Thymus 
B)  Reticuloendothelial system 
C)  Bone marrow 
D)  All of the above B

Question 4

In an immune response,______________  antibodies are formed before______________  .

Accepted Answer

A)  IgG, IgA 
B)  IgM, IgG 
C)  IgG, IgM 
D)  IgM, IgA 
A)  IgG, IgA 
B)  IgM, IgG 
C)  IgG, IgM 
D)  IgM, IgA

Question 5

What does hemolysis represent in an antigen-antibody reaction?

Accepted Answer

A)  A negative result 
B)  A positive result 
C)  An inconclusive result 
D)  None of the above 
A)  A negative result 
B)  A positive result 
C)  An inconclusive result 
D)  None of the above

Question 6

Which of the following are produced after exposure to genetically different nonself antigens of the same species?

Accepted Answer

A)  Alloantibodies 
B)  Autoantibodies 
C)  Drug-induced antibodies 
D)  All of the above 
A)  Alloantibodies 
B)  Autoantibodies 
C)  Drug-induced antibodies 
D)  All of the above

Question 7

What are the principle receptors for the FC portion of immunoglobulin and the CR1 complement component, respectively?

Accepted Answer

A)  IgM, C3b 
B)  IgG, C3b 
C)  IgG, C3d 
D)  IgM, C3d 
A)  IgM, C3b 
B)  IgG, C3b 
C)  IgG, C3d 
D)  IgM, C3d

Question 8

HDN is most often associated with what class of antibody?

Accepted Answer

A)  IgG1 
B)  IgM 
C)  IgE 
D)  IgG4 
A)  IgG1 
B)  IgM 
C)  IgE 
D)  IgG4

Question 9

A person with the genotype MM shows a 3+ reaction when red blood cells are mixed with M antisera; whereas a person with the genotype MN shows a 1+ reaction. What phenomenon is occurring here?

Accepted Answer

A)  Dosage 
B)  Prozone 
C)  Zeta potential 
D)  Hemolysis 
A)  Dosage 
B)  Prozone 
C)  Zeta potential 
D)  Hemolysis

Question 10

Which of the following antibodies is considered the most significant in blood banking because it reacts at body temperature?

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE

Question 11

IgG-coated RBCs will be phagocytized by what effector cells?

Accepted Answer

A)  Monocytes/macrophages 
B)  T cells 
C)  Eosinophils 
D)  Basophils 
A)  Monocytes/macrophages 
B)  T cells 
C)  Eosinophils 
D)  Basophils

Question 12

Which of the following blood group systems is not likely to cause HDN?

Accepted Answer

A)  Kell 
B)  ABO 
C)  MN 
D)  Rh 
A)  Kell 
B)  ABO 
C)  MN 
D)  Rh

Question 13

The four unique serum proteins of the alternate pathway of complement include all but which of the following?

Accepted Answer

A)  Factor B 
B)  X factor 
C)  Factor D 
D)  Initiating factor 
E)  Factor P 
A)  Factor B 
B)  X factor 
C)  Factor D 
D)  Initiating factor 
E)  Factor P

Question 14

When antigen and antibody combine, they are held together by noncovalent forces. With the absence of a visible lattice, this stage is called______________ .

Accepted Answer

A)  adhesion 
B)  sensitization 
C)  agglutination 
D)  inhibition 
A)  adhesion 
B)  sensitization 
C)  agglutination 
D)  inhibition

Question 15

The immune response that consists of physical barriers, biochemical effectors, and immune cells is the ______________ immune response.

Accepted Answer

A)  auto- 
B)  innate 
C)  localized 
D)  primary 
A)  auto- 
B)  innate 
C)  localized 
D)  primary

Question 16

Opsonization is:

Accepted Answer

A)  the coating of pathogens with factors that facilitate phagocytosis. 
B)  a major role of complement in immunity. 
C)  the binding of an opsonin, such as an antibody, to a receptor on the pathogen's cell membrane. 
D)  all of the above. 
A)  the coating of pathogens with factors that facilitate phagocytosis. 
B)  a major role of complement in immunity. 
C)  the binding of an opsonin, such as an antibody, to a receptor on the pathogen's cell membrane. 
D)  all of the above.

Question 17

An immunogenic substance that reacts with an antibody is:

Accepted Answer

A)  immunoglobulin. 
B)  antigen. 
C)  chromogen. 
D)  agglutinin. 
A)  immunoglobulin. 
B)  antigen. 
C)  chromogen. 
D)  agglutinin.

Question 18

What does polyspecific AHG contain?

Accepted Answer

A)  IgG 
B)  C3b 
C)  C3d 
D)  All of the above 
A)  IgG 
B)  C3b 
C)  C3d 
D)  All of the above

Question 19

In an immune response, what is the time called during which no antibody is detected in the test serum?

Accepted Answer

A)  Secondary response time 
B)  Primary response time 
C)  Latency period 
D)  Amnestic response time 
A)  Secondary response time 
B)  Primary response time 
C)  Latency period 
D)  Amnestic response time

Question 20

What function does chemically modified IgG serve?

Accepted Answer

A)  It creates a pentameric structure to enhance binding. 
B)  Disulfide bonds are reduced in the hinge region of IgG, which promotes flexibility of Fab portions. 
C)  It alters the light chain variability portion of molecule. 
D)  It dissociates the IgG molecules from surface of sensitized red blood cells. 
A)  It creates a pentameric structure to enhance binding. 
B)  Disulfide bonds are reduced in the hinge region of IgG, which promotes flexibility of Fab portions. 
C)  It alters the light chain variability portion of molecule. 
D)  It dissociates the IgG molecules from surface of sensitized red blood cells.

Exam 3: Fundamentals of Immunology

All of the following are functions performed by the complement system except:

Which is a characteristic of natural killer (NK) cells?

Extravascular hemolysis occurs when red blood cells are coated with antibody; what organ sequesters these cells?

In an immune response,______________ antibodies are formed before______________ .

What does hemolysis represent in an antigen-antibody reaction?

Which of the following are produced after exposure to genetically different nonself antigens of the same species?

What are the principle receptors for the FC portion of immunoglobulin and the CR1 complement component, respectively?

HDN is most often associated with what class of antibody?

A person with the genotype MM shows a 3+ reaction when red blood cells are mixed with M antisera; whereas a person with the genotype MN shows a 1+ reaction. What phenomenon is occurring here?

Which of the following antibodies is considered the most significant in blood banking because it reacts at body temperature?

IgG-coated RBCs will be phagocytized by what effector cells?

Which of the following blood group systems is not likely to cause HDN?

The four unique serum proteins of the alternate pathway of complement include all but which of the following?

When antigen and antibody combine, they are held together by noncovalent forces. With the absence of a visible lattice, this stage is called______________ .

The immune response that consists of physical barriers, biochemical effectors, and immune cells is the ______________ immune response.

Opsonization is:

An immunogenic substance that reacts with an antibody is:

What does polyspecific AHG contain?

In an immune response, what is the time called during which no antibody is detected in the test serum?

What function does chemically modified IgG serve?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

In an immune response, antibodies are formed before .