Question 1

What is the causative agent for Rocky Mountain spotted fever?

Accepted Answer

A)  Rickettsia rickettsii 
B)  Borrelia burgdorferi 
C)  Dolichos biflorus 
D)  Ehrlichia 
A)  Rickettsia rickettsii 
B)  Borrelia burgdorferi 
C)  Dolichos biflorus 
D)  Ehrlichia A

Question 2

HBsAg is what part of the hepatitis B virus?

Accepted Answer

A)  Core protein 
B)  Coat protein 
C)  Dane particle 
D)  Capsid protein 
A)  Core protein 
B)  Coat protein 
C)  Dane particle 
D)  Capsid protein B

Question 3

What treatment is recommended for chronic liver disease due to hepatitis C virus infection?

Accepted Answer

A)  Gamma globulin 
B)  Prednisone 
C)  Alpha interferon 
D)  Gamma interferon 
A)  Gamma globulin 
B)  Prednisone 
C)  Alpha interferon 
D)  Gamma interferon C

Question 4

Why is transmission of cytomegalovirus (CMV) through blood components not a significant risk to most recipients?

Accepted Answer

A)  Most recipients are CMV-positive. 
B)  Most recipients are CMV-negative. 
C)  The CMV cannot tolerate cold storage temperatures. 
D)  None of the above. 
A)  Most recipients are CMV-positive. 
B)  Most recipients are CMV-negative. 
C)  The CMV cannot tolerate cold storage temperatures. 
D)  None of the above.

Question 5

How is a donor's eligibility status affected when Western blot results are indeterminate over a period of 6 months and deemed as false-positives?

Accepted Answer

A)  Donor is placed on a re-entry list 
B)  Donor is eligible to donate 
C)  Donor is not eligible to donate 
D)  None of the above 
A)  Donor is placed on a re-entry list 
B)  Donor is eligible to donate 
C)  Donor is not eligible to donate 
D)  None of the above

Question 6

This disease can be transmitted through blood transfusion and is characterized by sponge-like lesions of the brain.

Accepted Answer

A)  Cytomegalovirus 
B)  Epstein-Barr virus 
C)  Creutzfeldt-Jakob disease 
D)  Chagas disease 
A)  Cytomegalovirus 
B)  Epstein-Barr virus 
C)  Creutzfeldt-Jakob disease 
D)  Chagas disease

Question 7

The most sensitive test for the detection of HIV infection is the:

Accepted Answer

A)  polymerase chain reaction. 
B)  Western blot. 
C)  immunofluorescence. 
D)  Southern blot. 
A)  polymerase chain reaction. 
B)  Western blot. 
C)  immunofluorescence. 
D)  Southern blot.

Question 8

In the HIV-1 virus is a core protein.

Accepted Answer

A)  gp41 
B)  p24 
C)  p55 
D)  p16 
A)  gp41 
B)  p24 
C)  p55 
D)  p16

Question 9

A person infected with HIV-1 is diagnosed with AIDS-related condition (ARC). What antibodies will be present in the patient's serum at this stage?

Accepted Answer

A)  Anti-p24 
B)  Anti-gp41 
C)  Anti-p26 
D)  Anti-p24 and anti-gp41 
A)  Anti-p24 
B)  Anti-gp41 
C)  Anti-p26 
D)  Anti-p24 and anti-gp41

Question 10

Which statement regarding HDV is true?

Accepted Answer

A)  The HDV is a DNA virus. 
B)  A carrier of hepatitis B virus cannot contract HDV infection. 
C)  Most HDV infections occur via blood transfusion. 
D)  HDV can occur simultaneously with hepatitis B virus. 
A)  The HDV is a DNA virus. 
B)  A carrier of hepatitis B virus cannot contract HDV infection. 
C)  Most HDV infections occur via blood transfusion. 
D)  HDV can occur simultaneously with hepatitis B virus.

Question 11

How is the hepatitis A virus usually spread?

Accepted Answer

A)  Oral-fecal route 
B)  Blood transfusion 
C)  Sexual transmission 
D)  None of the above 
A)  Oral-fecal route 
B)  Blood transfusion 
C)  Sexual transmission 
D)  None of the above

Question 12

Which of the following statements regarding the Western blot confirmation test for HIV infection is false?

Accepted Answer

A)  Viral components are distributed according to molecular weights. 
B)  Most persons with AIDS show bands to p24 and gp41. 
C)  Interpretation of test depends upon degree of immunofluorescence. 
D)  A purified viral lysate is dissolved in SDS and separated by PAGE electrophoresis. 
A)  Viral components are distributed according to molecular weights. 
B)  Most persons with AIDS show bands to p24 and gp41. 
C)  Interpretation of test depends upon degree of immunofluorescence. 
D)  A purified viral lysate is dissolved in SDS and separated by PAGE electrophoresis.

Question 13

Donors who have tested positive for syphilis are deferred for what period of time?

Accepted Answer

A)  Permanently 
B)  1 month post treatment 
C)  6 months post treatment 
D)  1 year post diagnosis with documentation of treatment 
A)  Permanently 
B)  1 month post treatment 
C)  6 months post treatment 
D)  1 year post diagnosis with documentation of treatment

Question 14

All of the following viruses have been associated with TAH except:

Accepted Answer

A)  hepatitis A. 
B)  hepatitis B. 
C)  hepatitis D. 
D)  hepatitis E. 
A)  hepatitis A. 
B)  hepatitis B. 
C)  hepatitis D. 
D)  hepatitis E.

Question 15

What is the source of hepatitis B immune globulin (HBIG)?

Accepted Answer

A)  Persons with a high titer of anti-HBc(IgG) 
B)  Persons with a high titer of anti-HBe 
C)  Persons with a high titer of anti-HBs 
D)  Persons with a high titer of anti-HBc(IgM) 
A)  Persons with a high titer of anti-HBc(IgG) 
B)  Persons with a high titer of anti-HBe 
C)  Persons with a high titer of anti-HBs 
D)  Persons with a high titer of anti-HBc(IgM)

Question 16

The hepatitis C virus is thought to be included in which family?

Accepted Answer

A)  Hepadnaviridae 
B)  Retroviridae 
C)  Flaviviridae 
D)  Picornaviridae 
A)  Hepadnaviridae 
B)  Retroviridae 
C)  Flaviviridae 
D)  Picornaviridae

Question 17

How can hepatitis A infection be prevented?

Accepted Answer

A)  Plasma protein fraction (PPF) 
B)  Normal serum albumin (NS
A)  
C)  Immune serum globulin (ISG) 
D)  Fresh frozen plasma (FPP) 
A)  Plasma protein fraction (PPF) 
B)  Normal serum albumin (NS
A)  
C)  Immune serum globulin (ISG) 
D)  Fresh frozen plasma (FPP)

Question 18

Which of the following is not included in the signs and symptoms of TAH?

Accepted Answer

A)  Jaundice 
B)  Splenomegaly 
C)  Dark urine 
D)  Acholic stools 
A)  Jaundice 
B)  Splenomegaly 
C)  Dark urine 
D)  Acholic stools

Question 19

What is the incubation period of hepatitis A virus in transfusion-associated hepatitis?

Accepted Answer

A)  40 to 60 days 
B)  90 to 180 days 
C)  20 to 40 days 
D)  1 to 20 days 
A)  40 to 60 days 
B)  90 to 180 days 
C)  20 to 40 days 
D)  1 to 20 days

Question 20

Which cell is invaded by the HIV viruses?

Accepted Answer

A)  Monocyte 
B)  Neutrophil 
C)  Lymphocyte 
D)  Basophil 
A)  Monocyte 
B)  Neutrophil 
C)  Lymphocyte 
D)  Basophil

Exam 18: Transfusion-Transmitted Diseases

What is the causative agent for Rocky Mountain spotted fever?

HBsAg is what part of the hepatitis B virus?

What treatment is recommended for chronic liver disease due to hepatitis C virus infection?

Why is transmission of cytomegalovirus (CMV) through blood components not a significant risk to most recipients?

How is a donor's eligibility status affected when Western blot results are indeterminate over a period of 6 months and deemed as false-positives?

This disease can be transmitted through blood transfusion and is characterized by sponge-like lesions of the brain.

The most sensitive test for the detection of HIV infection is the:

In the HIV-1 virus is a core protein.

A person infected with HIV-1 is diagnosed with AIDS-related condition (ARC). What antibodies will be present in the patient's serum at this stage?

Which statement regarding HDV is true?

How is the hepatitis A virus usually spread?

Which of the following statements regarding the Western blot confirmation test for HIV infection is false?

Donors who have tested positive for syphilis are deferred for what period of time?

All of the following viruses have been associated with TAH except:

What is the source of hepatitis B immune globulin (HBIG)?

The hepatitis C virus is thought to be included in which family?

How can hepatitis A infection be prevented?

Which of the following is not included in the signs and symptoms of TAH?

What is the incubation period of hepatitis A virus in transfusion-associated hepatitis?

Which cell is invaded by the HIV viruses?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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