Question 1

HIV belongs to which family?

Accepted Answer

A)  Flaviviridae 
B)  Retroviridae 
C)  Hepadnaviridae 
D)  Picornaviridae 
A)  Flaviviridae 
B)  Retroviridae 
C)  Hepadnaviridae 
D)  Picornaviridae

Question 2

Which of the following parasites has not been associated with transmission via blood transfusion?

Accepted Answer

A)  Trypanosoma cruzi 
B)  Plasmodium sp 
C)  Leishmania 
D)  None of the above 
A)  Trypanosoma cruzi 
B)  Plasmodium sp 
C)  Leishmania 
D)  None of the above

Question 3

Which two infectious agents share the same vector?

Accepted Answer

A)  Rickettsia and Leishmania 
B)  Babesia and Borrelia 
C)  Borrelia and Plasmodium 
D)  Babesia and Trypanosoma 
A)  Rickettsia and Leishmania 
B)  Babesia and Borrelia 
C)  Borrelia and Plasmodium 
D)  Babesia and Trypanosoma

Question 4

American Association of Blood Banks (AABB) Standards mandate the donor of blood or component given to a recipient who develops clinical or laboratory evidence of transfusion-associated hepatitis (TAH), HIV infection, or HTLV-I/II infection must be permanently deferred if the unit was:

Accepted Answer

A)  a directed donation. 
B)  the only unit transfused. 
C)  one of four transfused to the recipient. 
D)  positive for cytomegalovirus. 
A)  a directed donation. 
B)  the only unit transfused. 
C)  one of four transfused to the recipient. 
D)  positive for cytomegalovirus.

Question 5

A single donor tested positive for HIV-1 via enzyme immunoassay screening techniques. The blood was retested and found to be nonreactive. What is the status of the donor whole blood unit?

Accepted Answer

A)  A confirmatory test should be performed. 
B)  Blood and components are okay for use. 
C)  The unit should be discarded. 
D)  The donor should be placed on the re-entry list. 
A)  A confirmatory test should be performed. 
B)  Blood and components are okay for use. 
C)  The unit should be discarded. 
D)  The donor should be placed on the re-entry list.

Question 6

The cytomegalovirus and Epstein-Barr virus belong to which family of viruses?

Accepted Answer

A)  Flaviviridae 
B)  Retroviridae 
C)  Herpesviridae 
D)  Picornaviridae 
A)  Flaviviridae 
B)  Retroviridae 
C)  Herpesviridae 
D)  Picornaviridae

Question 7

A person with acute hepatitis B infection is immune to infection from other hepatitis viruses.

Accepted Answer

A) True 
 B)False

Question 8

Why are donors deferred for 6 months following receipt of blood products?

Accepted Answer

A)  To permit adequate screening for transfusion-acquired viral infections 
B)  Because donation may cause recurrence of the condition that required transfusion 
C)  To allow clearance of all transfused cells in the donor 
D)  To allow donor recovery from the condition that required transfusion 
A)  To permit adequate screening for transfusion-acquired viral infections 
B)  Because donation may cause recurrence of the condition that required transfusion 
C)  To allow clearance of all transfused cells in the donor 
D)  To allow donor recovery from the condition that required transfusion

Question 9

According to the Centers for Disease Control (CDC), an HIV-positive person is considered to have AIDS according to what criterion?

Accepted Answer

A)  Presence of anti-p24 
B)  Presence of anti-gp41 
C)  Fewer than 200 CD8+ T cells per µL 
D)  Fewer than 200 CD4+ T cells per µL 
A)  Presence of anti-p24 
B)  Presence of anti-gp41 
C)  Fewer than 200 CD8+ T cells per µL 
D)  Fewer than 200 CD4+ T cells per µL

Question 10

The hepatitis B virus belongs to which family?

Accepted Answer

A)  Picornaviridae 
B)  Hepadnaviridae 
C)  Flaviviridae 
D)  Retroviridae 
A)  Picornaviridae 
B)  Hepadnaviridae 
C)  Flaviviridae 
D)  Retroviridae

Question 11

In an individual infected with hepatitis B virus, which of the following is detected first?

Accepted Answer

A)  HBsAg 
B)  HBeAg 
C)  anti-HBc 
D)  anti-HBs 
A)  HBsAg 
B)  HBeAg 
C)  anti-HBc 
D)  anti-HBs

Question 12

What marker usually is not detected when the hepatitis B-infected patient enters the convalescent phase?

Accepted Answer

A)  Anti-HBc 
B)  HBsAg 
C)  HBeAg 
D)  Anti-HBe 
A)  Anti-HBc 
B)  HBsAg 
C)  HBeAg 
D)  Anti-HBe

Question 13

Which of the following viral infections poses a severe threat to chronically transfused individuals who carry the hepatitis B virus (HBV)?

Accepted Answer

A)  Superinfection by hepatitis C virus (HCV) 
B)  Infection with hepatitis G virus (HGV) 
C)  Superinfection by hepatitis D virus (HDV) 
D)  Non-A, non-B, non-C virus (NANBNC virus) 
A)  Superinfection by hepatitis C virus (HCV) 
B)  Infection with hepatitis G virus (HGV) 
C)  Superinfection by hepatitis D virus (HDV) 
D)  Non-A, non-B, non-C virus (NANBNC virus)

Question 14

A blood donor's serologic tests were reactive for HIV-1/2 antibodies. The test was repeated, and both were reactive. A Western blot confirmatory test was done and was negative. What is the protocol for this donor?

Accepted Answer

A)  Unit is discarded. 
B)  Health department is notified. 
C)  Unit is OK to use. 
D)  Donor is permanently deferred. 
A)  Unit is discarded. 
B)  Health department is notified. 
C)  Unit is OK to use. 
D)  Donor is permanently deferred.

Question 15

Which test can reveal an asymptomatic patient with TAH?

Accepted Answer

A)  BUN 
B)  AST 
C)  ALT 
D)  Amylase 
A)  BUN 
B)  AST 
C)  ALT 
D)  Amylase

Question 16

Which of the following findings is not part of the typical pattern of hepatitis A infection?

Accepted Answer

A)  Anti-HAV IgM antibodies 
B)  Anti-HAV IgG antibodies 
C)  Virus in stool 
D)  Elevated ALT 
A)  Anti-HAV IgM antibodies 
B)  Anti-HAV IgG antibodies 
C)  Virus in stool 
D)  Elevated ALT

Question 17

Persons infected with the hepatitis C virus may develop what disease?

Accepted Answer

A)  Chronic liver disease 
B)  Cirrhosis 
C)  Hepatocellular carcinoma 
D)  All of the above 
A)  Chronic liver disease 
B)  Cirrhosis 
C)  Hepatocellular carcinoma 
D)  All of the above

Question 18

Which of the following patients would be at a greater risk for CMV infection?

Accepted Answer

A)  An autologous transplant recipient 
B)  A low-birth-weight infant transfused with CMV-negative blood 
C)  An allogenic bone marrow transplant recipient 
D)  None of the above 
A)  An autologous transplant recipient 
B)  A low-birth-weight infant transfused with CMV-negative blood 
C)  An allogenic bone marrow transplant recipient 
D)  None of the above

Question 19

Which test for HIV infection depends on amplification of HIV integrated in the DNA of infected cells?

Accepted Answer

A)  Western blot 
B)  Polymerase chain reaction 
C)  Immunofluorescence 
D)  Enzyme-linked immunosorbent assay 
A)  Western blot 
B)  Polymerase chain reaction 
C)  Immunofluorescence 
D)  Enzyme-linked immunosorbent assay

Question 20

The hepatitis A virus belongs to which family of viruses?

Accepted Answer

A)  Retroviridae 
B)  Flaviviridae 
C)  Hepadnaviridae 
D)  Picornaviridae 
A)  Retroviridae 
B)  Flaviviridae 
C)  Hepadnaviridae 
D)  Picornaviridae

Exam 18: Transfusion-Transmitted Diseases

HIV belongs to which family?

Which of the following parasites has not been associated with transmission via blood transfusion?

Which two infectious agents share the same vector?

American Association of Blood Banks (AABB) Standards mandate the donor of blood or component given to a recipient who develops clinical or laboratory evidence of transfusion-associated hepatitis (TAH), HIV infection, or HTLV-I/II infection must be permanently deferred if the unit was:

A single donor tested positive for HIV-1 via enzyme immunoassay screening techniques. The blood was retested and found to be nonreactive. What is the status of the donor whole blood unit?

The cytomegalovirus and Epstein-Barr virus belong to which family of viruses?

A person with acute hepatitis B infection is immune to infection from other hepatitis viruses.

Why are donors deferred for 6 months following receipt of blood products?

According to the Centers for Disease Control (CDC), an HIV-positive person is considered to have AIDS according to what criterion?

The hepatitis B virus belongs to which family?

In an individual infected with hepatitis B virus, which of the following is detected first?

What marker usually is not detected when the hepatitis B-infected patient enters the convalescent phase?

Which of the following viral infections poses a severe threat to chronically transfused individuals who carry the hepatitis B virus (HBV)?

A blood donor's serologic tests were reactive for HIV-1/2 antibodies. The test was repeated, and both were reactive. A Western blot confirmatory test was done and was negative. What is the protocol for this donor?

Which test can reveal an asymptomatic patient with TAH?

Which of the following findings is not part of the typical pattern of hepatitis A infection?

Persons infected with the hepatitis C virus may develop what disease?

Which of the following patients would be at a greater risk for CMV infection?

Which test for HIV infection depends on amplification of HIV integrated in the DNA of infected cells?

The hepatitis A virus belongs to which family of viruses?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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