Question 1

Which of the following types of chromatin are open and actively involved in gene expression (transcription)?

Accepted Answer

A)  Heterochromatin 
B)  Homochromatin 
C)  Euchromatin 
D)  Interchromatin 
A)  Heterochromatin 
B)  Homochromatin 
C)  Euchromatin 
D)  Interchromatin C

Question 2

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

Accepted Answer

A)  Ring chromosome 
B)  Isochromosome 
C)  Derivative chromosome 
D)  Balanced translocation 
A)  Ring chromosome 
B)  Isochromosome 
C)  Derivative chromosome 
D)  Balanced translocation C

Question 3

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

Accepted Answer

A)  Kinetochore 
B)  Euchromatin 
C)  Histone protein H1 
D)  Heterochromatin 
A)  Kinetochore 
B)  Euchromatin 
C)  Histone protein H1 
D)  Heterochromatin A

Question 4

Human chromosomes 21 and 22 are described as which of the following with regard to the location of the centromere?

Accepted Answer

A)  Telocentric 
B)  Holocentric 
C)  Metacentric 
D)  Acrocentric 
A)  Telocentric 
B)  Holocentric 
C)  Metacentric 
D)  Acrocentric

Question 5

A chromosome that has the centromere in the center of the chromosome is called:

Accepted Answer

A)  Acrocentric 
B)  Telocentric 
C)  Metacentric 
D)  Holocentric 
A)  Acrocentric 
B)  Telocentric 
C)  Metacentric 
D)  Holocentric

Question 6

In a C banding pattern, what part of the chromosome stains?

Accepted Answer

A)  Whole chromosome 
B)  Heterochromatin 
C)  Euchromatin 
D)  Centromere 
A)  Whole chromosome 
B)  Heterochromatin 
C)  Euchromatin 
D)  Centromere

Question 7

Colcemid is used in the procedure of preparing a chromosome spread for karyotype analysis to do which of the following?

Accepted Answer

A)  Spread the chromosomes out within the cell 
B)  Inhibit microtubule formation 
C)  Induce cells to enter mitosis 
D)  Fix cells to the slide prior to staining 
A)  Spread the chromosomes out within the cell 
B)  Inhibit microtubule formation 
C)  Induce cells to enter mitosis 
D)  Fix cells to the slide prior to staining

Question 8

A nucleosome consists of DNA and which of the following combinations of histone proteins?

Accepted Answer

A)  2(H1), 2(H2
A) , 2(H3), 2(H4) 
B)  2(H2
A) , 2(H2
B) , 2(H3), 2(H4) 
C)  2(H1), 2(H2
A) , 2(H2
B) , 2(H4) 
D)  2(H2), 2(H3), 2(H4), 2(H5) 
A)  2(H1), 2(H2
A) , 2(H3), 2(H4) 
B)  2(H2
A) , 2(H2
B) , 2(H3), 2(H4) 
C)  2(H1), 2(H2
A) , 2(H2
B) , 2(H4) 
D)  2(H2), 2(H3), 2(H4), 2(H5)

Question 9

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

Accepted Answer

A)  Sub-band, band, chromosome, region 
B)  Region, band, sub-band, chromosome 
C)  Band, chromosome, region, sub-band 
D)  Chromosome, region, band, sub-band 
A)  Sub-band, band, chromosome, region 
B)  Region, band, sub-band, chromosome 
C)  Band, chromosome, region, sub-band 
D)  Chromosome, region, band, sub-band

Question 10

Down's syndrome is caused when an extra copy of chromosome 21 is created, which is what kind of genetic event?

Accepted Answer

A)  Gene mutation 
B)  Chromosome mutation 
C)  Genome mutation 
D)  Euploidy 
A)  Gene mutation 
B)  Chromosome mutation 
C)  Genome mutation 
D)  Euploidy

Question 11

What are the structures found only at the ends of human chromosomes?

Accepted Answer

A)  Kinetochores 
B)  Telomeres 
C)  Centromeres 
D)  Histones 
A)  Kinetochores 
B)  Telomeres 
C)  Centromeres 
D)  Histones

Question 12

Before its conversion to a microarray technique, CGH was performed by hybridizing labeled DNA to what support?

Accepted Answer

A)  Immobilized PCR products 
B)  Normal chromosome spread 
C)  Nitrocellulose membrane 
D)  Agarose gel 
A)  Immobilized PCR products 
B)  Normal chromosome spread 
C)  Nitrocellulose membrane 
D)  Agarose gel

Question 13

Which is the proper order for the four phases of the cell cycle?

Accepted Answer

A)  G1, S, M, G2 
B)  G1, S, G2, M 
C)  G2, S, M, G1 
D)  M, S, G1, G2 
A)  G1, S, M, G2 
B)  G1, S, G2, M 
C)  G2, S, M, G1 
D)  M, S, G1, G2

Question 14

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

Accepted Answer

A)  Examination of 20 spreads in interphase FISH has increased sensitivity. 
B)  One can identify mutations anywhere in the chromosome in interphase FISH. 
C)  Interphase FISH allows identification of all chromosomes. 
D)  Results are available faster in interphase FISH procedures than metaphase FISH procedures. 
A)  Examination of 20 spreads in interphase FISH has increased sensitivity. 
B)  One can identify mutations anywhere in the chromosome in interphase FISH. 
C)  Interphase FISH allows identification of all chromosomes. 
D)  Results are available faster in interphase FISH procedures than metaphase FISH procedures.

Question 15

The short arm of the chromosome is designated as which of the following?

Accepted Answer

A)  o 
B)  p 
C)  q 
D)  r 
A)  o 
B)  p 
C)  q 
D)  r

Question 16

Comparative genome hybridization detects which type of genetic abnormalities?

Accepted Answer

A)  Amplifications relative to reference DNA 
B)  Absolute gene numbers 
C)  Inversions 
D)  Amino acid substitutions 
A)  Amplifications relative to reference DNA 
B)  Absolute gene numbers 
C)  Inversions 
D)  Amino acid substitutions

Question 17

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

Accepted Answer

A)  Phenotype 
B)  Polymorphism 
C)  Aneuploid 
D)  Mutation 
A)  Phenotype 
B)  Polymorphism 
C)  Aneuploid 
D)  Mutation

Question 18

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

Accepted Answer

A)  Size 
B)  Degree of staining 
C)  Fluorescent color 
D)  Position 
A)  Size 
B)  Degree of staining 
C)  Fluorescent color 
D)  Position

Question 19

The karyotype of a normal male is designated by which of the following?

Accepted Answer

A)  46, XX 
B)  46, XY 
C)  47, XX 
D)  47, XY 
A)  46, XX 
B)  46, XY 
C)  47, XX 
D)  47, XY

Question 20

What is the designation of a cell with three copies of every chromosome?

Accepted Answer

A)  Euploid 
B)  Diploid 
C)  Triploid 
D)  Tetraploid 
A)  Euploid 
B)  Diploid 
C)  Triploid 
D)  Tetraploid

Which of the following types of chromatin are open and actively involved in gene expression (transcription)?

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

Human chromosomes 21 and 22 are described as which of the following with regard to the location of the centromere?

A chromosome that has the centromere in the center of the chromosome is called:

In a C banding pattern, what part of the chromosome stains?

Colcemid is used in the procedure of preparing a chromosome spread for karyotype analysis to do which of the following?

A nucleosome consists of DNA and which of the following combinations of histone proteins?

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

Down's syndrome is caused when an extra copy of chromosome 21 is created, which is what kind of genetic event?

What are the structures found only at the ends of human chromosomes?

Before its conversion to a microarray technique, CGH was performed by hybridizing labeled DNA to what support?

Which is the proper order for the four phases of the cell cycle?

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

The short arm of the chromosome is designated as which of the following?

Comparative genome hybridization detects which type of genetic abnormalities?

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

The karyotype of a normal male is designated by which of the following?

What is the designation of a cell with three copies of every chromosome?

DNA

RNA

Proteins

Nucleic Acid Extraction Methods

Resolution and Detection of Nucleic Acids

Analysis and Characterization of Nucleic Acids and Proteins

Nucleic Acid Amplification

Gene Mutations

DNA Sequencing

DNA Polymorphisms and Human Identification

Detection and Identification of Microorganisms

Molecular Detection of Inherited Diseases

Molecular Oncology

Dna-Based Tissue Typing

Quality Assurance and Quality Control in the Molecular Laboratory

Filters

Exam 8: Chromosomal Structure and Chromosomal Mutations

Which of the following types of chromatin are open and actively involved in gene expression (transcription)?

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

Human chromosomes 21 and 22 are described as which of the following with regard to the location of the centromere?

A chromosome that has the centromere in the center of the chromosome is called:

In a C banding pattern, what part of the chromosome stains?

Colcemid is used in the procedure of preparing a chromosome spread for karyotype analysis to do which of the following?

A nucleosome consists of DNA and which of the following combinations of histone proteins?

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

Down's syndrome is caused when an extra copy of chromosome 21 is created, which is what kind of genetic event?

What are the structures found only at the ends of human chromosomes?

Before its conversion to a microarray technique, CGH was performed by hybridizing labeled DNA to what support?

Which is the proper order for the four phases of the cell cycle?

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

The short arm of the chromosome is designated as which of the following?

Comparative genome hybridization detects which type of genetic abnormalities?

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

The karyotype of a normal male is designated by which of the following?

What is the designation of a cell with three copies of every chromosome?

DNA

RNA

Proteins

Nucleic Acid Extraction Methods

Resolution and Detection of Nucleic Acids

Analysis and Characterization of Nucleic Acids and Proteins

Nucleic Acid Amplification

Gene Mutations

DNA Sequencing

DNA Polymorphisms and Human Identification

Detection and Identification of Microorganisms

Molecular Detection of Inherited Diseases

Molecular Oncology

Dna-Based Tissue Typing

Quality Assurance and Quality Control in the Molecular Laboratory

Filters