Question 1

Platelet aggregation results in __________ as measured by a platelet aggregometer.

Accepted Answer

A)  Increased absorbance 
B)  Decreased transmittance 
C)  Decreased absorbance 
D)  Increased light scatter 
E)  None of the above 
A)  Increased absorbance 
B)  Decreased transmittance 
C)  Decreased absorbance 
D)  Increased light scatter 
E)  None of the above

Question 2

Plasmin is generated from a circulating inactive zymogen called __________.

Accepted Answer

A)  Plasminogen 
B)  Fibrin 
C)  Fibrinogen 
D)  Thrombin 
E)  Collagen 
A)  Plasminogen 
B)  Fibrin 
C)  Fibrinogen 
D)  Thrombin 
E)  Collagen

Question 3

The extrinsic system of coagulation is monitored by the __________.

Accepted Answer

A)  Activated partial thromboplastin time (APTT) 
B)  Prothrombin time (PT) 
C)  Fibrinogen assay 
D)  Thrombin time (TT) 
E)  Reptilase time 
A)  Activated partial thromboplastin time (APTT) 
B)  Prothrombin time (PT) 
C)  Fibrinogen assay 
D)  Thrombin time (TT) 
E)  Reptilase time

Question 4

The organelle zone is composed of __________.

Accepted Answer

A)  Alpha granules 
B)  Dense granules 
C)  Lysosomes 
D)  Glycogen 
E)  All of the above 
A)  Alpha granules 
B)  Dense granules 
C)  Lysosomes 
D)  Glycogen 
E)  All of the above

Question 5

What is the function of plasmin?

Accepted Answer

A)  Destroy fibrin and fibrinogen 
B)  Produce FDP 
C)  Destroy factors V, VIII 
D)  Indirectly enhances factor XII to XIIa 
E)  All of the above 
A)  Destroy fibrin and fibrinogen 
B)  Produce FDP 
C)  Destroy factors V, VIII 
D)  Indirectly enhances factor XII to XIIa 
E)  All of the above

Question 6

The platelet membrane represents a fluid lipid bilayer composed of:

Accepted Answer

A)  Glycoproteins 
B)  Glycolipids 
C)  Lipoproteins 
D)  All of the above 
E)  None of the above 
A)  Glycoproteins 
B)  Glycolipids 
C)  Lipoproteins 
D)  All of the above 
E)  None of the above

Question 7

All of the following are effective in aggregating platelets in vitro except:

Accepted Answer

A)  ADP 
B)  Magnesium 
C)  Collagen 
D)  Epinephrine 
E)  Thrombin 
A)  ADP 
B)  Magnesium 
C)  Collagen 
D)  Epinephrine 
E)  Thrombin

Question 8

The organelle region is responsible for the __________ activities of the platelet.

Accepted Answer

A)  Metabolic 
B)  Physical 
C)  Kinetic 
D)  Enzymatic 
E)  None of the above 
A)  Metabolic 
B)  Physical 
C)  Kinetic 
D)  Enzymatic 
E)  None of the above

Question 9

The thrombin time is a measure of the ability of thrombin to convert __________ to fibrin.

Accepted Answer

A)  Plasmin 
B)  Fibrinogen 
C)  Prothrombin 
D)  Plasminogen 
E)  Collagen 
A)  Plasmin 
B)  Fibrinogen 
C)  Prothrombin 
D)  Plasminogen 
E)  Collagen

Question 10

What major contractile protein in the platelet cytosol accounts for 20-30% of total platelet protein and functions within microtubules in organizing parallel filaments capable of contraction?

Accepted Answer

A)  Sphingomyelin 
B)  Myelin 
C)  Myosin 
D)  Actin 
E)  None of the above 
A)  Sphingomyelin 
B)  Myelin 
C)  Myosin 
D)  Actin 
E)  None of the above

Question 11

The clear zone of cytoplasm that surrounds a higher stained granulomere is termed __________.

Accepted Answer

A)  Collagen 
B)  Glycocalyx 
C)  Hyalomere 
D)  Centromere 
E)  None of the above 
A)  Collagen 
B)  Glycocalyx 
C)  Hyalomere 
D)  Centromere 
E)  None of the above

Question 12

What is the end product of coagulation?

Accepted Answer

A)  Thrombin 
B)  Fibrinogen 
C)  Prothrombin 
D)  Fibrin 
E)  None of the above 
A)  Thrombin 
B)  Fibrinogen 
C)  Prothrombin 
D)  Fibrin 
E)  None of the above

Question 13

The activation of __________ acts as the common link between the fibrinolytic system, the kinin system, and the complement system.

Accepted Answer

A)  Factor XI 
B)  Factor X 
C)  Factor XII 
D)  Factor V 
E)  Factor III 
A)  Factor XI 
B)  Factor X 
C)  Factor XII 
D)  Factor V 
E)  Factor III

Question 14

Enhanced fibrinolysis is present in which disease state(s)?

Accepted Answer

A)  Coagulopathies 
B)  Liver cirrhosis 
C)  Traumatic injuries 
D)  All of the above 
E)  None of the above 
A)  Coagulopathies 
B)  Liver cirrhosis 
C)  Traumatic injuries 
D)  All of the above 
E)  None of the above

Question 15

Which constituent of the peripheral zone contain glycoproteins responsible for blood group specificity (ABO), tissue compatibility [human leukocyte antigen (HLA)], and platelet antigenicity?

Accepted Answer

A)  Glycocalyx 
B)  Plasma membrane 
C)  Open canalicular system 
D)  Submembranous region 
E)  None of the above 
A)  Glycocalyx 
B)  Plasma membrane 
C)  Open canalicular system 
D)  Submembranous region 
E)  None of the above

Question 16

Which substance induces dense and alpha granule secretion?

Accepted Answer

A)  Thromboxane A2 (TXA2) 
B)  ADP 
C)  Epinephrine 
D)  Thrombin 
E)  All of the above 
A)  Thromboxane A2 (TXA2) 
B)  ADP 
C)  Epinephrine 
D)  Thrombin 
E)  All of the above

Question 17

Platelets will not aggregate in the absence of membrane __________.

Accepted Answer

A)  Glycoprotein 
B)  Fibrinogen-binding sites 
C)  Fibrinogen 
D)  Calcium 
E)  All of the above are necessary for platelet aggregation 
A)  Glycoprotein 
B)  Fibrinogen-binding sites 
C)  Fibrinogen 
D)  Calcium 
E)  All of the above are necessary for platelet aggregation

Question 18

What is the heparin cofactor?

Accepted Answer

A)  Protein C 
B)  Antithrombin III 
C)  Warfarin 
D)  Coumarin 
E)  None of the above 
A)  Protein C 
B)  Antithrombin III 
C)  Warfarin 
D)  Coumarin 
E)  None of the above

Question 19

The platelet structure is composed of:

Accepted Answer

A)  Peripheral zone 
B)  Sol-gel zone 
C)  Organelle zone 
D)  All of the above 
E)  None of the above 
A)  Peripheral zone 
B)  Sol-gel zone 
C)  Organelle zone 
D)  All of the above 
E)  None of the above

Question 20

The contact group of coagulation proteins includes all of the following except:

Accepted Answer

A)  Hageman factor 
B)  Plasma thromboplastin antecedent 
C)  Stuart-Prower factor 
D)  Prekallikrein 
E)  High-molecular-weight kininogen 
A)  Hageman factor 
B)  Plasma thromboplastin antecedent 
C)  Stuart-Prower factor 
D)  Prekallikrein 
E)  High-molecular-weight kininogen

Exam 24: Introduction to Hemostasis

Platelet aggregation results in __________ as measured by a platelet aggregometer.

Plasmin is generated from a circulating inactive zymogen called __________.

The extrinsic system of coagulation is monitored by the __________.

The organelle zone is composed of __________.

What is the function of plasmin?

The platelet membrane represents a fluid lipid bilayer composed of:

All of the following are effective in aggregating platelets in vitro except:

The organelle region is responsible for the __________ activities of the platelet.

The thrombin time is a measure of the ability of thrombin to convert __________ to fibrin.

What major contractile protein in the platelet cytosol accounts for 20-30% of total platelet protein and functions within microtubules in organizing parallel filaments capable of contraction?

The clear zone of cytoplasm that surrounds a higher stained granulomere is termed __________.

What is the end product of coagulation?

The activation of __________ acts as the common link between the fibrinolytic system, the kinin system, and the complement system.

Enhanced fibrinolysis is present in which disease state(s)?

Which constituent of the peripheral zone contain glycoproteins responsible for blood group specificity (ABO), tissue compatibility [human leukocyte antigen (HLA)], and platelet antigenicity?

Which substance induces dense and alpha granule secretion?

Platelets will not aggregate in the absence of membrane __________.

What is the heparin cofactor?

The platelet structure is composed of:

The contact group of coagulation proteins includes all of the following except:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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