Question 1

Fitzgerald factor corresponds to __________.

Accepted Answer

A)  Prothrombin 
B)  Prekallikrein 
C)  Fibrinogen 
D)  High-molecular-weight kininogen 
E)  None of the above 
A)  Prothrombin 
B)  Prekallikrein 
C)  Fibrinogen 
D)  High-molecular-weight kininogen 
E)  None of the above

Question 2

What is the coagulation factor assigned as factor VI?

Accepted Answer

A)  Calcium 
B)  Fibrinogen 
C)  Hageman factor 
D)  Christmas factor 
E)  None of the above 
A)  Calcium 
B)  Fibrinogen 
C)  Hageman factor 
D)  Christmas factor 
E)  None of the above

Question 3

Platelet factor III facilitates __________ formation by the intrinsic coagulation system.

Accepted Answer

A)  Plasmin 
B)  Thrombin 
C)  Fibrinogen 
D)  Fibrin 
E)  None of the above 
A)  Plasmin 
B)  Thrombin 
C)  Fibrinogen 
D)  Fibrin 
E)  None of the above

Question 4

What is the normal platelet count?

Accepted Answer

A)  300,000 to 500,000/µL 
B)  150,000 to 400,000/µL 
C)  500,000 to 700,000/µL 
D)  50,000 to 150,000/µL 
E)  None of the above 
A)  300,000 to 500,000/µL 
B)  150,000 to 400,000/µL 
C)  500,000 to 700,000/µL 
D)  50,000 to 150,000/µL 
E)  None of the above

Question 5

Glycocalyx, a mucopolysaccharide, coats the luminal surface of the endothelium and possesses the ability to stimulate weakly the physiologic anticoagulant __________.

Accepted Answer

A)  Coumarin 
B)  Heparin 
C)  Antithrombin III 
D)  Warfarin 
E)  None of the above 
A)  Coumarin 
B)  Heparin 
C)  Antithrombin III 
D)  Warfarin 
E)  None of the above

Question 6

Factor VII is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above 
A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 7

What factor(s) is/are inhibited by antithrombin III?

Accepted Answer

A)  Xa 
B)  IXa 
C)  XIIa 
D)  VIIIa 
E)  All of the above 
A)  Xa 
B)  IXa 
C)  XIIa 
D)  VIIIa 
E)  All of the above

Question 8

Which are cofactors in the blood coagulation system?

Accepted Answer

A)  Factor III 
B)  Factor V 
C)  Factor VIII 
D)  Fitzgerald factor 
E)  All of the above 
A)  Factor III 
B)  Factor V 
C)  Factor VIII 
D)  Fitzgerald factor 
E)  All of the above

Question 9

All of the following events occur under control of the intrinsic pathway except:

Accepted Answer

A)  Factor XII is activated to XIIa. 
B)  Factor VII activates X to Xa. 
C)  Factor XIa activates factor IX to IXa in the presence of calcium. 
D)  Factor IXa works with cofactor VIII and PF3 to activate factor X. 
E)  The macromolecular complex of IXa, VIII, X, and calcium assembles on the surface of activated platelets. 
A)  Factor XII is activated to XIIa. 
B)  Factor VII activates X to Xa. 
C)  Factor XIa activates factor IX to IXa in the presence of calcium. 
D)  Factor IXa works with cofactor VIII and PF3 to activate factor X. 
E)  The macromolecular complex of IXa, VIII, X, and calcium assembles on the surface of activated platelets.

Question 10

An abnormally prolonged PT will result from all of the following except:

Accepted Answer

A)  Vitamin K defect 
B)  Liver disease 
C)  Presence of inhibitors 
D)  Hypofibrinogenemia 
E)  None of the above 
A)  Vitamin K defect 
B)  Liver disease 
C)  Presence of inhibitors 
D)  Hypofibrinogenemia 
E)  None of the above

Question 11

Patients with platelet disorders usually exhibit __________.

Accepted Answer

A)  Telangiectasia 
B)  Petechiae 
C)  Hematomas 
D)  Ecchymosis 
E)  None of the above 
A)  Telangiectasia 
B)  Petechiae 
C)  Hematomas 
D)  Ecchymosis 
E)  None of the above

Question 12

The kinin system is activated by the coagulation and __________ systems.

Accepted Answer

A)  Complement 
B)  Fibrinolytic 
C)  Reticuloendothelial 
D)  All of the above 
E)  None of the above 
A)  Complement 
B)  Fibrinolytic 
C)  Reticuloendothelial 
D)  All of the above 
E)  None of the above

Question 13

Platelets are cellular fragments derived from the cytoplasm of __________ present in the bone marrow.

Accepted Answer

A)  Granulocytes 
B)  Megakaryocytes 
C)  Lymphocytes 
D)  Plasma cells 
E)  None of the above 
A)  Granulocytes 
B)  Megakaryocytes 
C)  Lymphocytes 
D)  Plasma cells 
E)  None of the above

Question 14

Which coagulation protein exclusively functions to create covalent bonds between the fibrin monomers formed during the coagulation process to form a stable fibrin clot?

Accepted Answer

A)  Factor II 
B)  Factor XIII 
C)  Factor XII 
D)  Factor IX 
E)  Factor III 
A)  Factor II 
B)  Factor XIII 
C)  Factor XII 
D)  Factor IX 
E)  Factor III

Question 15

Which additional factors are required to enhance or amplify the contact factors involved in the intrinsic system?

Accepted Answer

A)  Fletcher factor/Fitzgerald factor 
B)  Fletcher factor/Stuart-Prower factor 
C)  Christmas factor/Fletcher factor 
D)  Hageman factor/Christmas factor 
E)  None of the above 
A)  Fletcher factor/Fitzgerald factor 
B)  Fletcher factor/Stuart-Prower factor 
C)  Christmas factor/Fletcher factor 
D)  Hageman factor/Christmas factor 
E)  None of the above

Question 16

The release reaction from dense granules involves the secretion of __________.

Accepted Answer

A)  ADP 
B)  Serotonin 
C)  Calcium 
D)  All of the above 
E)  None of the above 
A)  ADP 
B)  Serotonin 
C)  Calcium 
D)  All of the above 
E)  None of the above

Question 17

The term used to describe the sol-gel zone is:

Accepted Answer

A)  Plasma membrane 
B)  Cytoskeleton 
C)  Peroxisomes 
D)  Glycocalyx 
E)  None of the above 
A)  Plasma membrane 
B)  Cytoskeleton 
C)  Peroxisomes 
D)  Glycocalyx 
E)  None of the above

Question 18

What is the function of FDPs?

Accepted Answer

A)  Increase vascular permeability and interfere with thrombin-induced fibrin formation 
B)  Decrease vascular permeability and interfere with thrombin-induced fibrin formation 
C)  Increase vascular permeability and accelerate thrombin-induced fibrin formation 
D)  All of the above 
E)  None of the above 
A)  Increase vascular permeability and interfere with thrombin-induced fibrin formation 
B)  Decrease vascular permeability and interfere with thrombin-induced fibrin formation 
C)  Increase vascular permeability and accelerate thrombin-induced fibrin formation 
D)  All of the above 
E)  None of the above

Question 19

The interrelationship of the coagulation, complement, and fibrinolytic systems is clinically demonstrated in what condition?

Accepted Answer

A)  Thromboembolism 
B)  Hereditary thrombophilia 
C)  Hemophilia 
D)  DIC 
E)  Christmas disease 
A)  Thromboembolism 
B)  Hereditary thrombophilia 
C)  Hemophilia 
D)  DIC 
E)  Christmas disease

Question 20

Antihemophilic factor corresponds to __________.

Accepted Answer

A)  Factor II 
B)  Factor IX 
C)  Factor VIII 
D)  Factor XII 
E)  None of the above 
A)  Factor II 
B)  Factor IX 
C)  Factor VIII 
D)  Factor XII 
E)  None of the above

Exam 24: Introduction to Hemostasis

Fitzgerald factor corresponds to __________.

What is the coagulation factor assigned as factor VI?

Platelet factor III facilitates __________ formation by the intrinsic coagulation system.

What is the normal platelet count?

Glycocalyx, a mucopolysaccharide, coats the luminal surface of the endothelium and possesses the ability to stimulate weakly the physiologic anticoagulant __________.

Factor VII is involved with which clotting pathway?

What factor(s) is/are inhibited by antithrombin III?

Which are cofactors in the blood coagulation system?

All of the following events occur under control of the intrinsic pathway except:

An abnormally prolonged PT will result from all of the following except:

Patients with platelet disorders usually exhibit __________.

The kinin system is activated by the coagulation and __________ systems.

Platelets are cellular fragments derived from the cytoplasm of __________ present in the bone marrow.

Which coagulation protein exclusively functions to create covalent bonds between the fibrin monomers formed during the coagulation process to form a stable fibrin clot?

Which additional factors are required to enhance or amplify the contact factors involved in the intrinsic system?

The release reaction from dense granules involves the secretion of __________.

The term used to describe the sol-gel zone is:

What is the function of FDPs?

The interrelationship of the coagulation, complement, and fibrinolytic systems is clinically demonstrated in what condition?

Antihemophilic factor corresponds to __________.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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