Question 1

Platelet factor 4 (PF4) neutralizes which anticoagulant?

Accepted Answer

A)  Protein C 
B)  Heparin 
C)  Warfarin 
D)  Coumarin 
E)  None of the above 
A)  Protein C 
B)  Heparin 
C)  Warfarin 
D)  Coumarin 
E)  None of the above

Question 2

What is the coagulation factor assigned as factor V?

Accepted Answer

A)  Calcium 
B)  Fibrinogen 
C)  Stabile factor 
D)  Labile factor 
E)  None of the above 
A)  Calcium 
B)  Fibrinogen 
C)  Stabile factor 
D)  Labile factor 
E)  None of the above

Question 3

Thromboxane A2, a potent aggregating agent of platelets, mediates the platelet __________ in addition to vasoconstriction.

Accepted Answer

A)  Adhesion 
B)  Precipitation 
C)  Release reaction 
D)  All of the above 
E)  None of the above 
A)  Adhesion 
B)  Precipitation 
C)  Release reaction 
D)  All of the above 
E)  None of the above

Question 4

Bleeding from arterioles and venules results in pinpoint __________ hemorrhage.

Accepted Answer

A)  Petechial 
B)  Ecchymoses 
C)  Epistaxis 
D)  All of the above 
E)  None of the above 
A)  Petechial 
B)  Ecchymoses 
C)  Epistaxis 
D)  All of the above 
E)  None of the above

Question 5

Aspirin prevents aggregation of platelets due to:

Accepted Answer

A)  Inactivation of PGI2 
B)  Inactivation of platelet cyclo-oxygenase 
C)  Amplification of PGI2 
D)  Inability of megakaryocytes to synthesize cyclo-oxygenase 
E)  None of the above 
A)  Inactivation of PGI2 
B)  Inactivation of platelet cyclo-oxygenase 
C)  Amplification of PGI2 
D)  Inability of megakaryocytes to synthesize cyclo-oxygenase 
E)  None of the above

Question 6

In the formation of a fibrin monomer, __________ cleaves a portion of the alpha and beta polypeptides in fibrinogen to form fibrinopeptide A and B.

Accepted Answer

A)  Thrombin 
B)  Plasmin 
C)  Prothrombin 
D)  Ristocetin 
E)  Collagen 
A)  Thrombin 
B)  Plasmin 
C)  Prothrombin 
D)  Ristocetin 
E)  Collagen

Question 7

Which of the following represents factor IV?

Accepted Answer

A)  Prothrombin 
B)  Stuart-Prower factor 
C)  Calcium 
D)  Hageman factor 
E)  None of the above 
A)  Prothrombin 
B)  Stuart-Prower factor 
C)  Calcium 
D)  Hageman factor 
E)  None of the above

Question 8

Factor X is assigned as what coagulation protein?

Accepted Answer

A)  Antihemophilic factor 
B)  Christmas factor 
C)  Stuart-Prower factor 
D)  Hageman factor 
E)  None of the above 
A)  Antihemophilic factor 
B)  Christmas factor 
C)  Stuart-Prower factor 
D)  Hageman factor 
E)  None of the above

Question 9

What is the coagulation protein assigned as factor I?

Accepted Answer

A)  Calcium 
B)  Prothrombin 
C)  Fibrinogen 
D)  Labile factor (proaccelerin) 
E)  None of the above 
A)  Calcium 
B)  Prothrombin 
C)  Fibrinogen 
D)  Labile factor (proaccelerin) 
E)  None of the above

Question 10

Activation of platelets results in which of the following?

Accepted Answer

A)  Stickiness 
B)  Adhesion 
C)  Shape change 
D)  Aggregation 
E)  All of the above 
A)  Stickiness 
B)  Adhesion 
C)  Shape change 
D)  Aggregation 
E)  All of the above

Question 11

Laboratory screening in evaluation of a bleeding disorder includes all of the following except:

Accepted Answer

A)  PT 
B)  Platelet count 
C)  APTT 
D)  Bleeding time 
E)  Fibrinogen 
A)  PT 
B)  Platelet count 
C)  APTT 
D)  Bleeding time 
E)  Fibrinogen

Question 12

All of the following are characteristics of the prothrombin group of coagulation proteins except:

Accepted Answer

A)  Factors are absorbed by BaSO4. 
B)  Vitamin K dependent. 
C)  Coagulation proteins are decreased in patients who are vitamin K deficient. 
D)  All factors are consumed during coagulation. 
E)  None of the above. 
A)  Factors are absorbed by BaSO4. 
B)  Vitamin K dependent. 
C)  Coagulation proteins are decreased in patients who are vitamin K deficient. 
D)  All factors are consumed during coagulation. 
E)  None of the above.

Question 13

What is the coagulation factor assigned as factor II?

Accepted Answer

A)  Fibrinogen 
B)  Prothrombin 
C)  Stuart-Prower factor 
D)  Hageman factor 
E)  None of the above 
A)  Fibrinogen 
B)  Prothrombin 
C)  Stuart-Prower factor 
D)  Hageman factor 
E)  None of the above

Question 14

Platelet membrane glycoprotein Ib is the receptor for __________, which serves to mediate the adhesion of platelets to subendothelium.

Accepted Answer

A)  von Willebrand factor 
B)  Christmas factor 
C)  Tissue factor 
D)  Stuart-Prower factor 
E)  Hageman factor 
A)  von Willebrand factor 
B)  Christmas factor 
C)  Tissue factor 
D)  Stuart-Prower factor 
E)  Hageman factor

Question 15

Factor XIII is assigned as what coagulation protein?

Accepted Answer

A)  Antihemophilic factor 
B)  Fibrin-stabilizing factor 
C)  Christmas factor 
D)  Hageman factor 
E)  None of the above 
A)  Antihemophilic factor 
B)  Fibrin-stabilizing factor 
C)  Christmas factor 
D)  Hageman factor 
E)  None of the above

Question 16

Prekallikrein is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above 
A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 17

What statement best describes the process of blood coagulation?

Accepted Answer

A)  A series of biochemical reactions that transforms circulating blood into an insoluble gel through conversion of fibrin to fibrinogen 
B)  A series of biochemical reactions that transforms circulating blood into an insoluble gel through conversion of fibrinogen to fibrin 
C)  The interaction of phospholipids and calcium on the platelet membrane resulting in aggregation. 
D)  The interaction of phospholipids and thrombin on the platelet membrane resulting in adhesion 
E)  None of the above 
A)  A series of biochemical reactions that transforms circulating blood into an insoluble gel through conversion of fibrin to fibrinogen 
B)  A series of biochemical reactions that transforms circulating blood into an insoluble gel through conversion of fibrinogen to fibrin 
C)  The interaction of phospholipids and calcium on the platelet membrane resulting in aggregation. 
D)  The interaction of phospholipids and thrombin on the platelet membrane resulting in adhesion 
E)  None of the above

Question 18

Primary hemostasis is defined as:

Accepted Answer

A)  The process of removing unwanted fibrin deposits following vascular injury 
B)  The process of cleaving fibrin degradation products into D and E fragments 
C)  The process of cleaving fibrin degradation products into D and Y fragments 
D)  The interaction of platelets and the vascular endothelium in halting bleeding following vascular injury 
E)  None of the above 
A)  The process of removing unwanted fibrin deposits following vascular injury 
B)  The process of cleaving fibrin degradation products into D and E fragments 
C)  The process of cleaving fibrin degradation products into D and Y fragments 
D)  The interaction of platelets and the vascular endothelium in halting bleeding following vascular injury 
E)  None of the above

Question 19

The fibrinolytic system is mediated by __________, which acts primarily on fibrin to produce lysis of the clot.

Accepted Answer

A)  Fibrinogen 
B)  Plasminogen 
C)  Plasmin 
D)  Thrombin 
E)  Reptilase 
A)  Fibrinogen 
B)  Plasminogen 
C)  Plasmin 
D)  Thrombin 
E)  Reptilase

Question 20

All of the following events occur in the extrinsic pathway except:

Accepted Answer

A)  Factor VII is activated to factor VIIa in the presence of calcium and tissue factor. 
B)  Factors VII, IV, and III activate factor X to Xa. 
C)  Thrombin generated enhances factors V and VIII to accelerate the intrinsic pathway. 
D)  Collagen activates factor XII to XIIa. 
E)  None of the above. 
A)  Factor VII is activated to factor VIIa in the presence of calcium and tissue factor. 
B)  Factors VII, IV, and III activate factor X to Xa. 
C)  Thrombin generated enhances factors V and VIII to accelerate the intrinsic pathway. 
D)  Collagen activates factor XII to XIIa. 
E)  None of the above.

Exam 24: Introduction to Hemostasis

Platelet factor 4 (PF4) neutralizes which anticoagulant?

What is the coagulation factor assigned as factor V?

Thromboxane A2, a potent aggregating agent of platelets, mediates the platelet __________ in addition to vasoconstriction.

Bleeding from arterioles and venules results in pinpoint __________ hemorrhage.

Aspirin prevents aggregation of platelets due to:

In the formation of a fibrin monomer, __________ cleaves a portion of the alpha and beta polypeptides in fibrinogen to form fibrinopeptide A and B.

Which of the following represents factor IV?

Factor X is assigned as what coagulation protein?

What is the coagulation protein assigned as factor I?

Activation of platelets results in which of the following?

Laboratory screening in evaluation of a bleeding disorder includes all of the following except:

All of the following are characteristics of the prothrombin group of coagulation proteins except:

What is the coagulation factor assigned as factor II?

Platelet membrane glycoprotein Ib is the receptor for __________, which serves to mediate the adhesion of platelets to subendothelium.

Factor XIII is assigned as what coagulation protein?

Prekallikrein is involved with which clotting pathway?

What statement best describes the process of blood coagulation?

Primary hemostasis is defined as:

The fibrinolytic system is mediated by __________, which acts primarily on fibrin to produce lysis of the clot.

All of the following events occur in the extrinsic pathway except:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Thromboxane A₂, a potent aggregating agent of platelets, mediates the platelet __________ in addition to vasoconstriction.