Exam 17: The Immune Response

What cellular structure is found to be expanded in plasma cells,but not in their precursor cells?

The HLA-B*35 MHC allele ________.

Which antibodies are the first to be secreted by B cells after antigen stimulation? They appear in the blood after a lag of a few days and have a relatively short half-life?

The rearranged DNA elements encoding the V regions of antibodies are estimated to have a mutation rate 105 times greater than that of other genetic loci in same cell.This phenomenon is referred to as __________.

What is formed when a V coding segment is joined to a J coding segment during DNA rearrangement to form an antibody?

Which class of T cells is composed of primarily inhibitory cells that suppress the proliferation and activities of other types of immune cells that are capable of mounting an autoimmune response?

Which cells are responsible for synthesizing and secreting antibodies?

B cells are activated by ________ and T cells are activated by ______.

Which of the following drugs is often used to help prevent rejection of a tissue transplant?

What causes phagocytic white blood cells like neutrophils and macrophages to migrate toward the site of infection?

Blood contains a group of soluble proteins,which bind extracellular pathogens and destroy them.In one case,an assembly of these activated soluble proteins perforates the bacterial cell membrane,causing lysis and death of the cells.What is this group of soluble proteins called?

The ability of maternal antibodies to get into the fetal circulation can lead to a life-threatening condition in which the fetal red blood cells are killed; this condition is known as ___________.

When does the full repertoire of antibody-producing cells (all such cells that a person will ever have)appear in the lymphoid tissue?

The human genome has been shown to code for 51 different functional VH segments,25 different DH segments and 6 JH segments for the heavy chain variable regions of antibodies.Assuming that any V segment can combine with any of the D and J segments,how many different heavy chains could be made?

Which bonds are largely responsible for holding the chains of an immunoglobulin together?

In an intact immunoglobulin molecule,each light chain domain associates with a heavy chain domain; each domain is encoded by __________.

How is class switching accomplished?

What immune system organ is located in the chest,is responsible for the differentiation of T cells and reaches its peak size during childhood?

What is the name for nucleated white blood cells that circulate between the blood and lymphoid organs?

The foreign substances that incite the body to make antibodies are called ________.