Exam 22: Population Genetics and Evolution

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Inbreeding depression, the reduction in fitness of inbred organisms, often results from the reduced level of what (within the gene pool)?

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What are the two most common types of nonrandom mating?

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In an island population, the frequencies of the three MN blood types are given here: M: 550 MN: 725 N: 225 a. Calculate the allele frequency of M and N. b. Assuming random mating, what are the expected frequencies for each blood type? c. Use chi-square analysis to test your hypothesis that mating is random for this population.

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If the frequency of hemophilia, an X-linked recessive disease, is 10% in males, what is the frequency of carriers in the population (both males and females)?

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Phenylketonuria (PKU)is extremely common in Ireland, affecting approximately 1 in 4500 live births. Assuming that the population is in Hardy-Weinberg equilibrium, what is the frequency of PKU carriers?

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You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in Hardy-Weinberg equilibrium due to population substructure, which method can be used to calculate allele frequency?

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What are the three key elements for determining F, a measure that a particular allele is IBD, using pedigree analysis?

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