Question 1

Which of the following may result in loss of function of a tumor suppressor gene?

Accepted Answer

A) Nondisjunction of sister chromatids 
B) Failure of a chromatid containing a tumor suppressor gene to attach to a spindle fiber during cell division 
C) Hypermethylation of the promoter for the gene 
D) A,B,and C 
E) None of the above 
A) Nondisjunction of sister chromatids 
B) Failure of a chromatid containing a tumor suppressor gene to attach to a spindle fiber during cell division 
C) Hypermethylation of the promoter for the gene 
D) A,B,and C 
E) None of the above D

Question 2

The chemical structure formed from the reaction of a DNA base with a carcinogen is called

Accepted Answer

A) A lesion. 
B) An adduct. 
C) An ultimate carcinogen. 
D) A xenobiotic. 
E) None of the above. 
A) A lesion. 
B) An adduct. 
C) An ultimate carcinogen. 
D) A xenobiotic. 
E) None of the above. B

Question 3

Which of the following mechanisms is involved in double-strand DNA repair?

Accepted Answer

A) Homology-dependent repair 
B) Nonhomologous end joining 
C) Mismatch repair 
D) A and B 
E) A,B,and C 
A) Homology-dependent repair 
B) Nonhomologous end joining 
C) Mismatch repair 
D) A and B 
E) A,B,and C D

Question 4

Which of the following types of mutations are advantageous to cancer cell growth?

Accepted Answer

A) Those resulting in defective mismatch repair 
B) Inherited defects in double-strand DNA repair 
C) A defect in nucleotide-excision repair 
D) A,B,and C 
E) None of the above 
A) Those resulting in defective mismatch repair 
B) Inherited defects in double-strand DNA repair 
C) A defect in nucleotide-excision repair 
D) A,B,and C 
E) None of the above

Question 5

Which of the following may result in point mutations that can contribute to cancer?

Accepted Answer

A) Deamination of 5-methylcytosine 
B) Unrepaired single-strand breaks during DNA synthesis 
C) Microsatellite instability 
D) Exposure to UV radiation 
E) All of the above 
A) Deamination of 5-methylcytosine 
B) Unrepaired single-strand breaks during DNA synthesis 
C) Microsatellite instability 
D) Exposure to UV radiation 
E) All of the above

Question 6

Which of the following types of cells are most protected from genomic damage?

Accepted Answer

A) Stem cells 
B) Differentiated cells 
C) Transit-amplifying cells 
D) Dividing cells 
E) A,B,and C 
A) Stem cells 
B) Differentiated cells 
C) Transit-amplifying cells 
D) Dividing cells 
E) A,B,and C

Question 7

Mutations that result in compromised function of the spindle assembly checkpoint during mitosis may directly contribute to

Accepted Answer

A) Impaired p53 function. 
B) Impaired DNA replication. 
C) Aneuploidy. 
D) A and B. 
E) None of the above. 
A) Impaired p53 function. 
B) Impaired DNA replication. 
C) Aneuploidy. 
D) A and B. 
E) None of the above.

Question 8

The DNA polymerase pol-δ

Accepted Answer

A) Is involved in DNA synthesis. 
B) Is involved in proofreading newly synthesized DNA. 
C) Exhibits exonuclease activity. 
D) A,B,and C. 
E) None of the above. 
A) Is involved in DNA synthesis. 
B) Is involved in proofreading newly synthesized DNA. 
C) Exhibits exonuclease activity. 
D) A,B,and C. 
E) None of the above.

Question 9

Which of the following is true of the BRCA1 gene?

Accepted Answer

A) Its product normally functions in DNA repair. 
B) Germ-line mutations in this gene are associated with an increased risk for breast and ovarian cancers. 
C) Somatic mutations in this gene are associated with an increased risk for ovarian cancer. 
D) A,B,and C. 
E) None of the above. 
A) Its product normally functions in DNA repair. 
B) Germ-line mutations in this gene are associated with an increased risk for breast and ovarian cancers. 
C) Somatic mutations in this gene are associated with an increased risk for ovarian cancer. 
D) A,B,and C. 
E) None of the above.

Question 10

A patient with chronic myelogenous leukemia CML)exhibits chromosomal translocations in both lymphocytes and myeloid cells.This suggests that the cell in which the initiating mutation occurred was MOST likely

Accepted Answer

A) A lymphocyte. 
B) A macrophage. 
C) A neutrophil. 
D) A hematopoietic stem cell. 
E) A myeloid precursor. 
A) A lymphocyte. 
B) A macrophage. 
C) A neutrophil. 
D) A hematopoietic stem cell. 
E) A myeloid precursor.

Question 11

Keratoses,or benign skin lesions,often exhibit

Accepted Answer

A) Mutant p53 alleles. 
B) Mutations carrying a dipyrimidine substitution. 
C) Mutations resulting from exposure to UV light. 
D) A,B,and C. 
E) None of the above. 
A) Mutant p53 alleles. 
B) Mutations carrying a dipyrimidine substitution. 
C) Mutations resulting from exposure to UV light. 
D) A,B,and C. 
E) None of the above.

Question 12

Defects in which of the following cellular processes may contribute to an increased incidence of cancer?

Accepted Answer

A) Nucleotide-excision repair 
B) Mismatch repair 
C) Base-excision repair 
D) A ,B,and C 
E) None of the above 
A) Nucleotide-excision repair 
B) Mismatch repair 
C) Base-excision repair 
D) A ,B,and C 
E) None of the above

Which of the following may result in loss of function of a tumor suppressor gene?

The chemical structure formed from the reaction of a DNA base with a carcinogen is called

Which of the following mechanisms is involved in double-strand DNA repair?

Which of the following types of mutations are advantageous to cancer cell growth?

Which of the following may result in point mutations that can contribute to cancer?

Which of the following types of cells are most protected from genomic damage?

Mutations that result in compromised function of the spindle assembly checkpoint during mitosis may directly contribute to

The DNA polymerase pol-δ

Which of the following is true of the BRCA1 gene?

A patient with chronic myelogenous leukemia CML)exhibits chromosomal translocations in both lymphocytes and myeloid cells.This suggests that the cell in which the initiating mutation occurred was MOST likely

Keratoses,or benign skin lesions,often exhibit

Defects in which of the following cellular processes may contribute to an increased incidence of cancer?

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Tumor Viruses

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

P53 and Apoptosis: Master Guardian and Executioner

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

Filters

Exam 12: Maintenance of Genomic Integrity and the Development of Cancer

Which of the following may result in loss of function of a tumor suppressor gene?

The chemical structure formed from the reaction of a DNA base with a carcinogen is called

Which of the following mechanisms is involved in double-strand DNA repair?

Which of the following types of mutations are advantageous to cancer cell growth?

Which of the following may result in point mutations that can contribute to cancer?

Which of the following types of cells are most protected from genomic damage?

Mutations that result in compromised function of the spindle assembly checkpoint during mitosis may directly contribute to

The DNA polymerase pol-δ

Which of the following is true of the BRCA1 gene?

A patient with chronic myelogenous leukemia CML)exhibits chromosomal translocations in both lymphocytes and myeloid cells.This suggests that the cell in which the initiating mutation occurred was MOST likely

Keratoses,or benign skin lesions,often exhibit

Defects in which of the following cellular processes may contribute to an increased incidence of cancer?

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Tumor Viruses

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

P53 and Apoptosis: Master Guardian and Executioner

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

Filters