Question 1

Some retroviruses are able to transform cells through

Accepted Answer

A) Inserting themselves near a proto-oncogene in the host genome. 
B) Acquiring oncogenes within their own genome. 
C) Possessing genes that specify proteins that activate cellular genes involved in proliferation. 
D) A,B,and C. 
E) None of the above. 
A) Inserting themselves near a proto-oncogene in the host genome. 
B) Acquiring oncogenes within their own genome. 
C) Possessing genes that specify proteins that activate cellular genes involved in proliferation. 
D) A,B,and C. 
E) None of the above. D

Question 2

Experiments using temperature-sensitive mutants of RSV to infect chicken embryo fibroblasts demonstrated that

Accepted Answer

A) Infection with RSV is necessary to initiate transformation of these cells,but the RSV genome is not needed to maintain the transformed state. 
B) The RSV transforming gene is necessary for both the initiation and maintenance of transformation in these cells. 
C) Infection with RSV alone is unable to transform these cells. 
D) Cells infected with RSV continue to exhibit normal cellular morphology. 
E) None of the above. 
A) Infection with RSV is necessary to initiate transformation of these cells,but the RSV genome is not needed to maintain the transformed state. 
B) The RSV transforming gene is necessary for both the initiation and maintenance of transformation in these cells. 
C) Infection with RSV alone is unable to transform these cells. 
D) Cells infected with RSV continue to exhibit normal cellular morphology. 
E) None of the above. B

Question 3

Which of the following is true of c-src?

Accepted Answer

A) It is present only in vertebrate cells containing integrated viral DNA. 
B) It results in cellular transformation. 
C) It is an example of a proto-oncogene. 
D) It is highly conserved among vertebrate species. 
E) C and D. 
A) It is present only in vertebrate cells containing integrated viral DNA. 
B) It results in cellular transformation. 
C) It is an example of a proto-oncogene. 
D) It is highly conserved among vertebrate species. 
E) C and D. E

Question 4

Dulbecco and Rubin discovered that they could infect chicken embryo fibroblasts with RSV in culture.Which of the following was NOT a characteristic exhibited by these cells after they were infected?

Accepted Answer

A) Virus particles were produced by these cells for many weeks. 
B) Cells formed clusters,or foci,after infection. 
C) The cells seemed to demonstrate uninhibited proliferation. 
D) The cells exhibited flattened morphology. 
E) The cells exhibited metabolic properties similar to those observed in tumor cells. 
A) Virus particles were produced by these cells for many weeks. 
B) Cells formed clusters,or foci,after infection. 
C) The cells seemed to demonstrate uninhibited proliferation. 
D) The cells exhibited flattened morphology. 
E) The cells exhibited metabolic properties similar to those observed in tumor cells.

Question 5

Which of the following enzymes are encoded by retroviral DNA?

Accepted Answer

A) Integrase. 
B) Reverse transcriptase. 
C) RNA polymerase II. 
D) A and B. 
E) None of these enzymes are encoded by retroviral DNA. 
A) Integrase. 
B) Reverse transcriptase. 
C) RNA polymerase II. 
D) A and B. 
E) None of these enzymes are encoded by retroviral DNA.

Question 6

Once a cell has been infected with a virus,how might viral genes be transmitted from mother to daughter cells?

Accepted Answer

A) Viral DNA carries its own replication machinery,replicating its own genome independently of host enzymes. 
B) Viral DNA may be integrated into the host cell's chromosomes,so that it is replicated along with host DNA prior to cell division. 
C) Viral DNA may be linked to host DNA through protein bridges,allowing it to tag along with host chromosomal DNA during cell division. 
D) B and C. 
E) All of the above. 
A) Viral DNA carries its own replication machinery,replicating its own genome independently of host enzymes. 
B) Viral DNA may be integrated into the host cell's chromosomes,so that it is replicated along with host DNA prior to cell division. 
C) Viral DNA may be linked to host DNA through protein bridges,allowing it to tag along with host chromosomal DNA during cell division. 
D) B and C. 
E) All of the above.

Question 7

The ability of cells suspended in soft semi-solid)agar medium to form colonies is a good predictor that

Accepted Answer

A) These cells will form tumors if injected subcutaneously into immunocompromised mice. 
B) These cells have stopped proliferating and will die. 
C) These cells would fail to grow in normal medium. 
D) These cells have an increased requirement for growth factors. 
E) None of the above. 
A) These cells will form tumors if injected subcutaneously into immunocompromised mice. 
B) These cells have stopped proliferating and will die. 
C) These cells would fail to grow in normal medium. 
D) These cells have an increased requirement for growth factors. 
E) None of the above.

Question 8

Which of the following is considered to be a tumor virus?

Accepted Answer

A) Hepatitis B virus HBV) 
B) Human papillomavirus HPV) 
C) Shope fibroma virus 
D) Human adenovirus 5 
E) All of the above 
A) Hepatitis B virus HBV) 
B) Human papillomavirus HPV) 
C) Shope fibroma virus 
D) Human adenovirus 5 
E) All of the above

Question 9

Scientists may map the insertion sites of viruses in DNA isolated from tumors that formed following retroviral infection in order to

Accepted Answer

A) Identify the viral genes responsible for transformation. 
B) Discover new proto-oncogenes. 
C) Determine how viruses suppress tumorigenesis. 
D) Understand how viruses infect cells. 
E) All of the above. 
A) Identify the viral genes responsible for transformation. 
B) Discover new proto-oncogenes. 
C) Determine how viruses suppress tumorigenesis. 
D) Understand how viruses infect cells. 
E) All of the above.

Question 10

A gene found in a normal cell's genome that can be picked up and altered by a virus to drive cellular transformation is known as

Accepted Answer

A) An oncogene 
B) A proto-oncogene 
C) A transgene 
D) A protogene 
E) None of the above 
A) An oncogene 
B) A proto-oncogene 
C) A transgene 
D) A protogene 
E) None of the above

Question 11

Which of the following is true of retroviruses?

Accepted Answer

A) They are DNA viruses. 
B) Their replication cycle requires DNA to be transcribed to RNA. 
C) The DNA versions of their viral genomes are called proviruses. 
D) B and C. 
E) None of the above. 
A) They are DNA viruses. 
B) Their replication cycle requires DNA to be transcribed to RNA. 
C) The DNA versions of their viral genomes are called proviruses. 
D) B and C. 
E) None of the above.

Question 12

Which of the following is a property of transformed cells?

Accepted Answer

A) Rounded shape 
B) Reduced requirement for mitogenic growth factors 
C) Loss of contact inhibition 
D) Increased transport of glucose 
E) All of the above 
A) Rounded shape 
B) Reduced requirement for mitogenic growth factors 
C) Loss of contact inhibition 
D) Increased transport of glucose 
E) All of the above

Some retroviruses are able to transform cells through

Experiments using temperature-sensitive mutants of RSV to infect chicken embryo fibroblasts demonstrated that

Which of the following is true of c-src?

Dulbecco and Rubin discovered that they could infect chicken embryo fibroblasts with RSV in culture.Which of the following was NOT a characteristic exhibited by these cells after they were infected?

Which of the following enzymes are encoded by retroviral DNA?

Once a cell has been infected with a virus,how might viral genes be transmitted from mother to daughter cells?

The ability of cells suspended in soft semi-solid)agar medium to form colonies is a good predictor that

Which of the following is considered to be a tumor virus?

Scientists may map the insertion sites of viruses in DNA isolated from tumors that formed following retroviral infection in order to

A gene found in a normal cell's genome that can be picked up and altered by a virus to drive cellular transformation is known as

Which of the following is true of retroviruses?

Which of the following is a property of transformed cells?

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

P53 and Apoptosis: Master Guardian and Executioner

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Maintenance of Genomic Integrity and the Development of Cancer

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

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Exam 3: Tumor Viruses

Some retroviruses are able to transform cells through

Experiments using temperature-sensitive mutants of RSV to infect chicken embryo fibroblasts demonstrated that

Which of the following is true of c-src?

Dulbecco and Rubin discovered that they could infect chicken embryo fibroblasts with RSV in culture.Which of the following was NOT a characteristic exhibited by these cells after they were infected?

Which of the following enzymes are encoded by retroviral DNA?

Once a cell has been infected with a virus,how might viral genes be transmitted from mother to daughter cells?

The ability of cells suspended in soft semi-solid)agar medium to form colonies is a good predictor that

Which of the following is considered to be a tumor virus?

Scientists may map the insertion sites of viruses in DNA isolated from tumors that formed following retroviral infection in order to

A gene found in a normal cell's genome that can be picked up and altered by a virus to drive cellular transformation is known as

Which of the following is true of retroviruses?

Which of the following is a property of transformed cells?

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

P53 and Apoptosis: Master Guardian and Executioner

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Maintenance of Genomic Integrity and the Development of Cancer

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

Filters