Question 1

The definition of a transposon is a segment of

Accepted Answer

A)  DNA that can move from one region to another. 
B)  RNA that can move from one region to another. 
C)  DNA that is easily transcribed. 
D)  DNA that is in need of repair. 
A)  DNA that can move from one region to another. 
B)  RNA that can move from one region to another. 
C)  DNA that is easily transcribed. 
D)  DNA that is in need of repair.

Question 2

HIVRT is closely related to which DNA polymerase?

Accepted Answer

A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol IV 
A)  Pol I 
B)  Pol II 
C)  Pol III 
D)  Pol IV

Question 3

Mutation of the BRCA protein can lead to

Accepted Answer

A)  breast cancer. 
B)  lymphoma. 
C)  arthritis. 
D)  bone tumors. 
A)  breast cancer. 
B)  lymphoma. 
C)  arthritis. 
D)  bone tumors.

Question 4

Eukaryotic genomes overcome the slow synthesis rate by

Accepted Answer

A)  eliminating the need for unwinding the DNA. 
B)  providing more replication origins. 
C)  using multiple primases. 
D)  only replicating part of the DNA in one cycle. 
A)  eliminating the need for unwinding the DNA. 
B)  providing more replication origins. 
C)  using multiple primases. 
D)  only replicating part of the DNA in one cycle.

Question 5

The definition of a retrotransposon is a segment of

Accepted Answer

A)  DNA that goes through an RNA intermediate to be moved. 
B)  RNA that goes through a DNA intermediate to be moved. 
C)  DNA that needs to be excised. 
D)  DNA that is folded incorrectly. 
A)  DNA that goes through an RNA intermediate to be moved. 
B)  RNA that goes through a DNA intermediate to be moved. 
C)  DNA that needs to be excised. 
D)  DNA that is folded incorrectly.

Question 6

Describe the mechanism for repair of DNA damage by photolyase.

Accepted Answer

As shown in Figure 20.41 in the text, DN

Question 7

The role of CDK in DNA synthesis is to

Accepted Answer

A)  remove the histones. 
B)  block further production of pre-RCs while converting pre-RC to RPC. 
C)  block further production of methylated DNA. 
D)  terminate synthesis. 
A)  remove the histones. 
B)  block further production of pre-RCs while converting pre-RC to RPC. 
C)  block further production of methylated DNA. 
D)  terminate synthesis.

Question 8

The function of Dam methylase in DNA synthesis is to methylate the

Accepted Answer

A)  new DNA strand. 
B)  old DNA strand. 
C)  RNA primer. 
D)  primase. 
A)  new DNA strand. 
B)  old DNA strand. 
C)  RNA primer. 
D)  primase.

Question 9

All DNA is synthesized in which direction?

Accepted Answer

A)  5 '  $\rightarrow$3 ' 
B)  3 '  $\rightarrow$5 ' 
C)  1 '  $\rightarrow$5 ' 
D)  5 '  $\rightarrow$ 1 ' 
A)  5 '  $\rightarrow$3 ' 
B)  3 '  $\rightarrow$5 ' 
C)  1 '  $\rightarrow$5 ' 
D)  5 '  $\rightarrow$ 1 '

Question 10

What is the name for the relationship between the original DNA and replicate DNA?

Accepted Answer

A)  father and son 
B)  parent and children 
C)  parent and daughter 
D)  mother and daughter 
A)  father and son 
B)  parent and children 
C)  parent and daughter 
D)  mother and daughter

Question 11

Distinguish between base excision and nucleotide excision repair.

Accepted Answer

Base excision repair is responsible for

Question 12

MGMT is called the suicide enzyme because its active site permanently becomes

Accepted Answer

A)  phosphorylated. 
B)  methylated. 
C)  protonated. 
D)  ionized. 
A)  phosphorylated. 
B)  methylated. 
C)  protonated. 
D)  ionized.

Question 13

Lynch syndrome is a genetic deficiency in repairs.

Accepted Answer

A)  DNA excision 
B)  single-strand 
C)  double-strand 
D)  mismatch 
A)  DNA excision 
B)  single-strand 
C)  double-strand 
D)  mismatch

Question 14

What is the correct order of the following steps to synthesize new DNA? 1. Addition of an RNA primer
2) Extension of the RNA primer
3) Conversion of double-stranded DNA to single-stranded DNA
4) Synthesize new DNA

Accepted Answer

A)  1; 2; 3; 4 
B)  2; 3; 4; 1 
C)  3; 1; 2; 4 
D)  4; 1; 3; 2 
A)  1; 2; 3; 4 
B)  2; 3; 4; 1 
C)  3; 1; 2; 4 
D)  4; 1; 3; 2

Question 15

If 1 5N DNA replicated using conservative replication in 1 4N media, the outcome would be that new DNA has

Accepted Answer

A)  a single intermediate density. 
B)  a lower density. 
C)  only the higher density. 
D)  one high density and one low density strand. 
A)  a single intermediate density. 
B)  a lower density. 
C)  only the higher density. 
D)  one high density and one low density strand.

Question 16

DNA crossover is important during meiosis because it allows

Accepted Answer

A)  the organization of genes on the chromosome to change. 
B)  DNA repair to occur. 
C)  exchange of genetic information. 
D)  base excision to occur. 
A)  the organization of genes on the chromosome to change. 
B)  DNA repair to occur. 
C)  exchange of genetic information. 
D)  base excision to occur.

Question 17

Cytosine can be deaminated because it has a free that can be removed.

Accepted Answer

A)  keto group 
B)  amine 
C)  amide group 
D)  ester group 
A)  keto group 
B)  amine 
C)  amide group 
D)  ester group

Question 18

If a cell has many ROS species, what is the most likely reaction with DNA?

Accepted Answer

A)  Nothing, because ROS do not react with DNA. 
B)  G-C to T-A replacement 
C)  O-alkylation of thymine 
D)  single point excision 
A)  Nothing, because ROS do not react with DNA. 
B)  G-C to T-A replacement 
C)  O-alkylation of thymine 
D)  single point excision

Question 19

Base excision repair removes which kind of bases?

Accepted Answer

A)  mismatched 
B)  methylated 
C)  those damaged by ROS 
D)  uracil 
A)  mismatched 
B)  methylated 
C)  those damaged by ROS 
D)  uracil

Question 20

Homologous recombination can only be used in late S phase or G2 phase because it

Accepted Answer

A)  requires the presence of an intact sister chromatid as a template. 
B)  does not require the presence of a homologous template. 
C)  requires the cell to be in cell division. 
D)  requires the cell to be in the resting phase. 
A)  requires the presence of an intact sister chromatid as a template. 
B)  does not require the presence of a homologous template. 
C)  requires the cell to be in cell division. 
D)  requires the cell to be in the resting phase.

Exam 20: DNA Replication, Repair, and Recombination

The definition of a transposon is a segment of

HIVRT is closely related to which DNA polymerase?

Mutation of the BRCA protein can lead to

Eukaryotic genomes overcome the slow synthesis rate by

The definition of a retrotransposon is a segment of

Describe the mechanism for repair of DNA damage by photolyase.

The role of CDK in DNA synthesis is to

The function of Dam methylase in DNA synthesis is to methylate the

All DNA is synthesized in which direction?

What is the name for the relationship between the original DNA and replicate DNA?

Distinguish between base excision and nucleotide excision repair.

MGMT is called the suicide enzyme because its active site permanently becomes

Lynch syndrome is a genetic deficiency in repairs.

What is the correct order of the following steps to synthesize new DNA? 1. Addition of an RNA primer 2) Extension of the RNA primer 3) Conversion of double-stranded DNA to single-stranded DNA 4) Synthesize new DNA

If 1 5N DNA replicated using conservative replication in 1 4N media, the outcome would be that new DNA has

DNA crossover is important during meiosis because it allows

Cytosine can be deaminated because it has a free that can be removed.

If a cell has many ROS species, what is the most likely reaction with DNA?

Base excision repair removes which kind of bases?

Homologous recombination can only be used in late S phase or G2 phase because it

Principles of Biochemistry

Physical Biochemistry: Energy Conversion, Water, and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

RNA Synthesis, Processing, and Gene Silencing

Protein Synthesis, Posttranslational Modification, and Transport

Gene Regulation

Filters

If ^{1 5}N DNA replicated using conservative replication in ^{1 4}N media, the outcome would be that new DNA has