Exam 11: Chromosome Structure and Dna Sequence Organization

How do VNTRs relate to DNA fingerprinting?

When native chromatin is digested with micrococcal nuclease, what significant result occurs?

Briefly state what is meant by repetitive DNA.

What are histones, and how are they arranged in nucleosomes?

What is the function of a TERRA (telomere repeat -containing RNA)?

Compare and contrast the chromosome structure of viruses, bacteria, and eukaryotes.

In the formation of nucleosomes, one histone class, H1, is not directly involved, yet it does associate with DNA to form higher -level chromosomal structures. Where does this histone (H1) associate?

Telomerase is an enzyme involved in the replication of the ends of eukaryotic chromosomes.

Viral genomes are always linear, double -stranded DNA.

Each human contains an identical set of VNTRs.

A particular variant of the lambda bacteriophage has a DNA double -stranded genome of 51,365 base pairs. How long would this DNA be?

List the components of a nucleosome.

In human chromosomes, satellite DNA sequences of about 170 base pairs in length are present in tandem arrays of up to 1 million base pairs. Found mainly in centromere regions, these DNA sequences are called _.

Although mutations have been observed in many different genes, they have not been isolated in histones. Why does this seem reasonable? If one wanted to produce antibodies to histones, would it be an easy task? Explain your answer.