Question 1

In microsatellites,one-,two-,or three-base sequences are repeated about

Accepted Answer

A)  one million times. 
B)  one hundred thousand times. 
C)  one thousand times. 
D)  two hundred times. 
E)  15-100 times. 
A)  one million times. 
B)  one hundred thousand times. 
C)  one thousand times. 
D)  two hundred times. 
E)  15-100 times. E

Question 2

Misalignment during synapsis is a source of additional number of repeats in minisatellites.

Accepted Answer

A) True 
 B)False  True

Question 3

All DNA sequence changes in the CFTR gene lead to the disease called cystic fibrosis.

Accepted Answer

A) True 
 B)False  False

Question 4

Mapping a disease gene in humans requires

Accepted Answer

A)  large families with pedigrees and DNA sequences. 
B)  large numbers of mapped physical markers with complete genomic coverage and small families with pedigrees and DNA sequences. 
C)  small numbers of mapped markers and small families with pedigrees and DNA sequences 
D)  a multi-generational selective breeding program. 
E)  either large families with pedigrees and DNA sequences or large numbers of mapped physical markers with complete genomic coverage and small families with pedigrees and DNA sequences. 
A)  large families with pedigrees and DNA sequences. 
B)  large numbers of mapped physical markers with complete genomic coverage and small families with pedigrees and DNA sequences. 
C)  small numbers of mapped markers and small families with pedigrees and DNA sequences 
D)  a multi-generational selective breeding program. 
E)  either large families with pedigrees and DNA sequences or large numbers of mapped physical markers with complete genomic coverage and small families with pedigrees and DNA sequences.

Question 5

Define a locus in a classic sense and define it in a modern sense.How are the two definitions similar and different?

Accepted Answer

In the Mendel,Morgan,or classic sense,a

Question 6

The genetic role of minisatellites is well known.

Accepted Answer

A) True 
 B)False

Question 7

Lack of strong hybridization by an allele-specific probe of about 20 bases to DNA to be tested indicates

Accepted Answer

A)  a normal,unchanged sequence. 
B)  a polymorphic sequence. 
C)  that the probe is too short. 
D)  that the probe is too long. 
E)  The information given is not enough. 
A)  a normal,unchanged sequence. 
B)  a polymorphic sequence. 
C)  that the probe is too short. 
D)  that the probe is too long. 
E)  The information given is not enough.

Question 8

SNP is the acronym for:

Accepted Answer

A)  simple Northern probe. 
B)  single nucleotide polymorphism. 
C)  sample in situ probe. 
D)  simple nucleotide probe. 
E)  small nuclear particle 
A)  simple Northern probe. 
B)  single nucleotide polymorphism. 
C)  sample in situ probe. 
D)  simple nucleotide probe. 
E)  small nuclear particle

Question 9

Two parents believed that their baby had been switched with another couple's baby at the hospital.The other couple was certain that they had their own baby and that the infants had not been switched.All the parents agreed to DNA fingerprinting for themselves and their babies to resolve the issue.The image below represents an electrophoretic gel analysis of microsatellites for two pairs of parents and the babies they had taken home (M1 = mother #1,M2 = mother #2,F1 = father #1,F2 = father #2,B1 = baby #1,B2 = baby #2).Use the data from these profiles to answer the following questions: a)Does baby #1 most likely belong to mother #1 and father #1? b)What evidence is there,if any,that baby #1 cannot belong to mother #2 and father #2? c)Is it possible that father #1 and mother #2 are secretly lovers and are actually the parents of baby #1? d)Is it possible that mother #1 and father #2 are actually the parents of baby #2? e)Is this test sufficient to establish paternity? Why or why not?

Accepted Answer

@#IMG-DLM& a)Baby #1 does most likely belong to mo

Question 10

Microsatellites tend to be highly conserved,that is,once made they stay the same.

Accepted Answer

A) True 
 B)False

Question 11

Molecular geneticists equate an allele with

Accepted Answer

A)  only transcribed genes. 
B)  only non-transcribed DNA. 
C)  any DNA site that is different among genomes. 
D)  any DNA site that is different among coding genomes. 
E)  any DNA site that is different among non-coding genomes. 
A)  only transcribed genes. 
B)  only non-transcribed DNA. 
C)  any DNA site that is different among genomes. 
D)  any DNA site that is different among coding genomes. 
E)  any DNA site that is different among non-coding genomes.

Question 12

Thalidomide was a common treatment for morning sickness in the 1950s.Children born to mothers given this drug showed the phenotypes of a genetic disease known as phocomelia,which involves shortened limbs.This may represent

Accepted Answer

A)  incomplete dominance. 
B)  genetic heterogeneity. 
C)  penetrance. 
D)  phenocopy. 
E)  incomplete penetrance. 
A)  incomplete dominance. 
B)  genetic heterogeneity. 
C)  penetrance. 
D)  phenocopy. 
E)  incomplete penetrance.

Question 13

In microsatellite analysis,all of the following are applicable except

Accepted Answer

A)  must know the sequence of flanking markers. 
B)  must know the sequence of the repeat units in the microsatellite. 
C)  polymorphism is a matter of DNA size. 
D)  electrophoresis. 
E)  PCR. 
A)  must know the sequence of flanking markers. 
B)  must know the sequence of the repeat units in the microsatellite. 
C)  polymorphism is a matter of DNA size. 
D)  electrophoresis. 
E)  PCR.

Question 14

If a couple has a child who suffers from cystic fibrosis,then both must be carriers.

Accepted Answer

A) True 
 B)False

Question 15

QTL is the acronym for quantitative trait loci.

Accepted Answer

A) True 
 B)False

Question 16

Phenocopy of genetic diseases can arise from

Accepted Answer

A)  environmental stimuli in adulthood. 
B)  environmental stimuli in utero. 
C)  genetic alterations. 
D)  All of the choices are correct. 
E)  None of the choices are correct. 
A)  environmental stimuli in adulthood. 
B)  environmental stimuli in utero. 
C)  genetic alterations. 
D)  All of the choices are correct. 
E)  None of the choices are correct.

Question 17

A gene is simply a coding locus.

Accepted Answer

A) True 
 B)False

Question 18

Compare and contrast the definition of an allele by Mendel,Morgan,and other classical geneticists to the definition offered by current geneticists.

Accepted Answer

Mendel and Morgan identified the existen

Question 19

Nearly all SNPs are biallelic.

Accepted Answer

A) True 
 B)False

Question 20

DNA fingerprinting established that Anna Anderson was the same as Grand Duchess Anastasia.

Accepted Answer

A) True 
 B)False

Exam 14: Organellar Inheritance

In microsatellites,one-,two-,or three-base sequences are repeated about

Misalignment during synapsis is a source of additional number of repeats in minisatellites.

All DNA sequence changes in the CFTR gene lead to the disease called cystic fibrosis.

Mapping a disease gene in humans requires

Define a locus in a classic sense and define it in a modern sense.How are the two definitions similar and different?

The genetic role of minisatellites is well known.

Lack of strong hybridization by an allele-specific probe of about 20 bases to DNA to be tested indicates

SNP is the acronym for:

Microsatellites tend to be highly conserved,that is,once made they stay the same.

Molecular geneticists equate an allele with

Thalidomide was a common treatment for morning sickness in the 1950s.Children born to mothers given this drug showed the phenotypes of a genetic disease known as phocomelia,which involves shortened limbs.This may represent

In microsatellite analysis,all of the following are applicable except

If a couple has a child who suffers from cystic fibrosis,then both must be carriers.

QTL is the acronym for quantitative trait loci.

Phenocopy of genetic diseases can arise from

A gene is simply a coding locus.

Compare and contrast the definition of an allele by Mendel,Morgan,and other classical geneticists to the definition offered by current geneticists.

Nearly all SNPs are biallelic.

DNA fingerprinting established that Anna Anderson was the same as Grand Duchess Anastasia.

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

Dna Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Genomes

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetic Analysis of Development

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

Exploring Synthetic Biology: Concepts, Techniques, and Applications

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