Question 1

An important aspect of transport by facilitated transporters and pumps is ________.

Accepted Answer

A) conformational shifts 
B) rigidity 
C) softness 
D) $\alpha$-helix secondary structure 
E) $\beta$-pleated sheet secondary structure 
A) conformational shifts 
B) rigidity 
C) softness 
D) $\alpha$-helix secondary structure 
E) $\beta$-pleated sheet secondary structure

Question 2

Integral membrane proteins have been engineered to lack the portion that normally projects into the extracellular space. When the gene is inserted in cells, what happens to the mobility of this protein in the membrane?

Accepted Answer

A) It moves at a much faster rate than the wild type protein. 
B) It moves at a much slower rate than the intact protein. 
C) It does not move at all. 
D) It is not inserted into the membrane so nothing can be learned about their mobility. 
E) It flips to the opposite leaflet. 
A) It moves at a much faster rate than the wild type protein. 
B) It moves at a much slower rate than the intact protein. 
C) It does not move at all. 
D) It is not inserted into the membrane so nothing can be learned about their mobility. 
E) It flips to the opposite leaflet.

Question 3

Where in a myelinated axon are nearly all of the ion channels concentrated?

Accepted Answer

A) the cell body 
B) nodes of Ranvier 
C) dendrites 
D) axon terminals 
E) neuron nucleus 
A) the cell body 
B) nodes of Ranvier 
C) dendrites 
D) axon terminals 
E) neuron nucleus

Question 4

Glycolipids have been shown to play roles in certain disease states in humans and other mammals. Which of the situations below illustrate the ways in which this can happen?

Accepted Answer

A) malformed glycolipids can cause neurological disease 
B) mice with missing glycolipids had muscular tremors 
C) they are the site at which bacterial toxins like those that cause botulism and cholera first bind cells 
D) they are the site at which the influenza virus first binds a cell 
E) all of these are correct 
A) malformed glycolipids can cause neurological disease 
B) mice with missing glycolipids had muscular tremors 
C) they are the site at which bacterial toxins like those that cause botulism and cholera first bind cells 
D) they are the site at which the influenza virus first binds a cell 
E) all of these are correct

Question 5

What happens to phospholipid mobility when the cell is treated with agents that disrupt the underlying membrane skeleton?

Accepted Answer

A) Mobility is unchanged. 
B) Mobility is increased because the fences that normally restrict their diffusion are removed. 
C) Mobility is decreased because the fences that normally restrict their diffusion are removed. 
D) Mobility is increased because the treatment raises the temperature. 
E) Mobility is decreased because the treatment lowers the temperature. 
A) Mobility is unchanged. 
B) Mobility is increased because the fences that normally restrict their diffusion are removed. 
C) Mobility is decreased because the fences that normally restrict their diffusion are removed. 
D) Mobility is increased because the treatment raises the temperature. 
E) Mobility is decreased because the treatment lowers the temperature.

Question 6

You fuse a mouse cell and a human cell and then treat the cell with anti-mouse or anti-human protein-directed antibodies that are covalently linked to fluorescent dyes (antibodies to mouse proteins show green fluorescence; antibodies to human proteins show red fluorescence). What does the cell look like immediately after fusion?

Accepted Answer

A) The cell is half red and half green. 
B) The red and green labels are uniformly distributed across the entire membrane. 
C) The red and green labels are distributed in intermingled patches. 
D) The cell appears to be yellow in color. 
E) The cell appears to be brown in color. 
A) The cell is half red and half green. 
B) The red and green labels are uniformly distributed across the entire membrane. 
C) The red and green labels are distributed in intermingled patches. 
D) The cell appears to be yellow in color. 
E) The cell appears to be brown in color.

Question 7

Where is the neuron cell nucleus located?

Accepted Answer

A) axon hillock 
B) cell body 
C) dendrites 
D) axon 
E) terminal knob 
A) axon hillock 
B) cell body 
C) dendrites 
D) axon 
E) terminal knob

Question 8

Which protein in the red blood cell membrane appears to be responsible for the exchange of bicarbonate ions and chloride ions across the red blood cell membrane?

Accepted Answer

A) glycophorin A 
B) glycophorin D 
C) band 3 
D) glyceraldehyde 3-phosphate 
E) alpha-actinin 
A) glycophorin A 
B) glycophorin D 
C) band 3 
D) glyceraldehyde 3-phosphate 
E) alpha-actinin

Question 9

The sodium-potassium pump makes the cell interior more _________ by pumping _______ sodium ions out of the cell for every ___________ potassium ions pumped in.

Accepted Answer

A) negative, 3, 2 
B) negative, 2, 3 
C) positive, 3, 2 
D) positive, 2, 3 
E) negative, 4, 3 
A) negative, 3, 2 
B) negative, 2, 3 
C) positive, 3, 2 
D) positive, 2, 3 
E) negative, 4, 3

Question 10

Which enzyme releases certain membrane proteins from a membrane and was instrumental in the discovery of GPI-anchored proteins?

Accepted Answer

A) phospholipase 
B) lipase 
C) hydroxyurease 
D) protease 
E) trypsin 
A) phospholipase 
B) lipase 
C) hydroxyurease 
D) protease 
E) trypsin

Question 11

Which of the following is a function of membranes?

Accepted Answer

A) compartmentalization 
B) creating a selectively permeable barrier 
C) mediating intercellular interactions 
D) helping cells respond to external stimuli 
E) all of these are correct choices 
A) compartmentalization 
B) creating a selectively permeable barrier 
C) mediating intercellular interactions 
D) helping cells respond to external stimuli 
E) all of these are correct choices

Question 12

Why are proteins separated on an SDS polyacrylamide gel equally attracted to the positive electrode?

Accepted Answer

A) They carry a relatively uniform positive charge distribution 
B) They carry a relatively uniform negative charge distribution. 
C) They are all the same molecular weight. 
D) They are all the same size. 
E) They all have the same degree of hydrophobicity. 
A) They carry a relatively uniform positive charge distribution 
B) They carry a relatively uniform negative charge distribution. 
C) They are all the same molecular weight. 
D) They are all the same size. 
E) They all have the same degree of hydrophobicity.

Question 13

An amino acid is made to replace another amino acid in membrane-spanning $\alpha$-helices by site-directed mutagenesis of the gene coding for the protein. This is done in order to determine how close together two such $\alpha$-helices are in the structure of an integral protein. The amino acid is added to facilitate the attachment of a nitroxide group which can be used to detect position The amino acid substituted is:____________________.

Accepted Answer

A) phenylalanine 
B) alanine 
C) cysteine 
D) methionine 
E) proline 
A) phenylalanine 
B) alanine 
C) cysteine 
D) methionine 
E) proline

Question 14

Which technique allows an investigation of the microheterogeneity of a membrane so that one can see localized differences in protein distribution within membranes?

Accepted Answer

A) freeze-denture replication 
B) freeze-fracture replication 
C) X-ray crystallography 
D) circular dichroism 
E) quick-freeze replication 
A) freeze-denture replication 
B) freeze-fracture replication 
C) X-ray crystallography 
D) circular dichroism 
E) quick-freeze replication

Question 15

Concentrated areas of sphingolipids and cholesterol that are more gelated and ordered than the surrounding fluid membrane are called ______________ .

Accepted Answer

A) lipid islands 
B) collections 
C) lipid rafts 
D) lipid domains 
E) dense bilayers 
A) lipid islands 
B) collections 
C) lipid rafts 
D) lipid domains 
E) dense bilayers

Question 16

People who have the A blood type possess ________.

Accepted Answer

A) an enzyme that adds an N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids 
B) an enzyme that adds a galactose to the end of the oligosaccharide chain on RBC membrane glycolipids 
C) an enzyme that adds phospholipids to the end of the oligosaccharide chain on RBC membrane glycolipids 
D) no enzymes capable of attaching galactose or N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids 
E) both an enzyme that adds an N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids and an enzyme that adds a galactose to the end of the oligosaccharide chain on RBC membrane glycolipids 
A) an enzyme that adds an N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids 
B) an enzyme that adds a galactose to the end of the oligosaccharide chain on RBC membrane glycolipids 
C) an enzyme that adds phospholipids to the end of the oligosaccharide chain on RBC membrane glycolipids 
D) no enzymes capable of attaching galactose or N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids 
E) both an enzyme that adds an N-acetylgalactosamine to the end of the oligosaccharide chain on RBC membrane glycolipids and an enzyme that adds a galactose to the end of the oligosaccharide chain on RBC membrane glycolipids

Question 17

Synaptic malfunction or dysfunction may cause which of the following diseases?

Accepted Answer

A) myasthenia gravis 
B) Parkinson's disease 
C) schizophrenia 
D) depression 
E) all of these are correct 
A) myasthenia gravis 
B) Parkinson's disease 
C) schizophrenia 
D) depression 
E) all of these are correct

Question 18

What technique utilizes the properties of nitroxides to be sensitive to the distance that separates them and an unpaired electron?

Accepted Answer

A) site-directed mutagenesis 
B) site-directed amenuensis 
C) hydropathy plots 
D) electron paramagnetic resonance (EPR)spectroscopy 
E) infrared spectroscopy 
A) site-directed mutagenesis 
B) site-directed amenuensis 
C) hydropathy plots 
D) electron paramagnetic resonance (EPR)spectroscopy 
E) infrared spectroscopy

Question 19

What evidence convinced Overton that membranes were composed of lipids?

Accepted Answer

A) He could see the lipids in the microscope. 
B) Membranes were destroyed by enzymes that degraded lipids. 
C) More lipid-soluble solutes entered root hair cells faster than polar solutes. 
D) Membranes dissolved in gasoline. 
E) Membranes did not dissolve in water. 
A) He could see the lipids in the microscope. 
B) Membranes were destroyed by enzymes that degraded lipids. 
C) More lipid-soluble solutes entered root hair cells faster than polar solutes. 
D) Membranes dissolved in gasoline. 
E) Membranes did not dissolve in water.

Question 20

Hemolytic anemias are characterized by fragile, abnormally shaped erythrocytes; the disease has been traced to mutations in ________.

Accepted Answer

A) both actin and spectrin 
B) both actin and ankyrin 
C) hemoglobin 
D) spectrin 
E) both ankyrin and spectrin 
A) both actin and spectrin 
B) both actin and ankyrin 
C) hemoglobin 
D) spectrin 
E) both ankyrin and spectrin

An important aspect of transport by facilitated transporters and pumps is ________.

Integral membrane proteins have been engineered to lack the portion that normally projects into the extracellular space. When the gene is inserted in cells, what happens to the mobility of this protein in the membrane?

Where in a myelinated axon are nearly all of the ion channels concentrated?

Glycolipids have been shown to play roles in certain disease states in humans and other mammals. Which of the situations below illustrate the ways in which this can happen?

What happens to phospholipid mobility when the cell is treated with agents that disrupt the underlying membrane skeleton?

Where is the neuron cell nucleus located?

Which protein in the red blood cell membrane appears to be responsible for the exchange of bicarbonate ions and chloride ions across the red blood cell membrane?

The sodium-potassium pump makes the cell interior more _____ by pumping _ sodium ions out of the cell for every _________ potassium ions pumped in.

Which enzyme releases certain membrane proteins from a membrane and was instrumental in the discovery of GPI-anchored proteins?

Which of the following is a function of membranes?

Why are proteins separated on an SDS polyacrylamide gel equally attracted to the positive electrode?

Which technique allows an investigation of the microheterogeneity of a membrane so that one can see localized differences in protein distribution within membranes?

Concentrated areas of sphingolipids and cholesterol that are more gelated and ordered than the surrounding fluid membrane are called ______________ .

People who have the A blood type possess ________.

Synaptic malfunction or dysfunction may cause which of the following diseases?

What technique utilizes the properties of nitroxides to be sensitive to the distance that separates them and an unpaired electron?

What evidence convinced Overton that membranes were composed of lipids?

Hemolytic anemias are characterized by fragile, abnormally shaped erythrocytes; the disease has been traced to mutations in ________.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes and Metabolism

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

Cancer

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 4: The Structure and Function of the Plasma Membrane

An important aspect of transport by facilitated transporters and pumps is ________.

Integral membrane proteins have been engineered to lack the portion that normally projects into the extracellular space. When the gene is inserted in cells, what happens to the mobility of this protein in the membrane?

Where in a myelinated axon are nearly all of the ion channels concentrated?

Glycolipids have been shown to play roles in certain disease states in humans and other mammals. Which of the situations below illustrate the ways in which this can happen?

What happens to phospholipid mobility when the cell is treated with agents that disrupt the underlying membrane skeleton?

Where is the neuron cell nucleus located?

Which protein in the red blood cell membrane appears to be responsible for the exchange of bicarbonate ions and chloride ions across the red blood cell membrane?

The sodium-potassium pump makes the cell interior more _________ by pumping _______ sodium ions out of the cell for every ___________ potassium ions pumped in.

Which enzyme releases certain membrane proteins from a membrane and was instrumental in the discovery of GPI-anchored proteins?

Which of the following is a function of membranes?

Why are proteins separated on an SDS polyacrylamide gel equally attracted to the positive electrode?

Which technique allows an investigation of the microheterogeneity of a membrane so that one can see localized differences in protein distribution within membranes?

Concentrated areas of sphingolipids and cholesterol that are more gelated and ordered than the surrounding fluid membrane are called ______________ .

People who have the A blood type possess ________.

Synaptic malfunction or dysfunction may cause which of the following diseases?

What technique utilizes the properties of nitroxides to be sensitive to the distance that separates them and an unpaired electron?

What evidence convinced Overton that membranes were composed of lipids?

Hemolytic anemias are characterized by fragile, abnormally shaped erythrocytes; the disease has been traced to mutations in ________.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes and Metabolism

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

Cancer

The Immune Response

Techniques in Cell and Molecular Biology

Filters

The sodium-potassium pump makes the cell interior more _____ by pumping _ sodium ions out of the cell for every _________ potassium ions pumped in.