Exam 7: Replication, Maintenance, and Rearrangements of Genomic Dna

When a thymine dimer is encountered on the DNA template strand, what mechanism is responsible for correcting it on the newly synthesized strand?

The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are genes coding proteins involved in the DNA repair mechanism called

Which eukaryotic DNA polymerase replicates the lagging strand in the 3ʹ to 5ʹ direction?

DNA polymerases can synthesize DNA

Why is telomerase important in cancer cells?

Why does the proofreading activity of DNA polymerases rely on synthesis in the 5ʹ to 3ʹ direction as opposed to the 3ʹ to 5ʹ direction?

Which eukaryotic DNA polymerase replicates the leading strand in the 5'to 3'direction?

_______ can be beneficial to organisms such as amphibians to accommodate the generation of large pools of rRNAs, while it can be deleterious in some forms of cancer by dramatically increasing the number of genes driving proliferation.

Why does DNA polymerase synthesize DNA only in the 5ʹ to 3ʹ direction?

In E. coli, the major enzyme responsible for DNA replication is DNA polymerase

The twisting of the parental DNA strands around each other ahead of a replication fork is relieved by enzymes called

Yeast origins of replication are autonomously replicating sequences.

Site-specific recombination

Telomeres are the

Explain Tonegawa's key conclusion about the development of immunoglobulin genes.

IgM antibodies contain _______ constant regions in their heavy chains.

Somatic hypermutation is focused in the diversity region of the immunoglobulin gene.

In eukaryotic cells, RNA primers are removed by the combined action of 5ʹ to 3ʹ exonucleases and

The proofreading property of DNA polymerase is due to its _______ activity.

Both topoisomerase I and topoisomerase II allow DNA to relieve torsion.