Question 1

What type of DNA damage would you expect to occur more frequently in populations as they near the equator?

Accepted Answer

Given the greater intensity of sunlight

Question 2

The genes that encode the immunoglobulin light chain consist of regions that are called _______, _______, and _______.

Accepted Answer

variable (

Question 3

Though not a common mechanism, gene amplification is used by cells to rapidly give rise to multiple copies of mRNAs to meet large demands for particular proteins. How is gene amplification accomplished? Give an example of when a cell may activate this process.

Accepted Answer

Gene amplification occurs through repeat

Question 4

Deamination of cytosine results in the conversion of cytosine to

Accepted Answer

A)  hypoxanthine. 
B)  adenine. 
C)  7-methyl guanosine. 
D)  uracil. 
A)  hypoxanthine. 
B)  adenine. 
C)  7-methyl guanosine. 
D)  uracil.

Question 5

The BRCA genes responsible for inherited breast cancer are involved in the repair of _______ DNA breaks by homologous recombination.

Accepted Answer

double-str

Question 6

In addition to synthesizing DNA, DNA polymerase I has a second catalytic activity: it can

Accepted Answer

A)  synthesize short RNA sequences. 
B)  synthesize short polypeptide sequences. 
C)  remove RNA primers. 
D)  ligate short segments of DNA together. 
A)  synthesize short RNA sequences. 
B)  synthesize short polypeptide sequences. 
C)  remove RNA primers. 
D)  ligate short segments of DNA together.

Question 7

The rate of DNA replication in mammalian cells is tenfold faster than in prokaryotic cells.

Accepted Answer

A) True 
 B)False

Question 8

Which statement about gene amplification is false?

Accepted Answer

A)  Gene amplification is responsible for amplification of ribosomal RNA genes in amphibian oocytes. 
B)  Amplified DNA sequences can be found as free extrachromosomal molecules. 
C)  Gene amplification occurs as an abnormal event in cancer cells. 
D)  Amplified DNA sequences are a common occurrence in virally infected cells. 
A)  Gene amplification is responsible for amplification of ribosomal RNA genes in amphibian oocytes. 
B)  Amplified DNA sequences can be found as free extrachromosomal molecules. 
C)  Gene amplification occurs as an abnormal event in cancer cells. 
D)  Amplified DNA sequences are a common occurrence in virally infected cells.

Question 9

During mismatch repair in E. coli, the parental strand is recognized by

Accepted Answer

A)  single-stranded breaks. 
B)  glycosylated adenines. 
C)  methylated adenines. 
D)  methylation of the O6 position of guanine residues. 
A)  single-stranded breaks. 
B)  glycosylated adenines. 
C)  methylated adenines. 
D)  methylation of the O6 position of guanine residues.

Question 10

Patients with hereditary nonpolyposis colorectal cancer genes should have

Accepted Answer

A)  frequent colonoscopies. 
B)  a colectomy. 
C)  gene-replacement therapy. 
D)  an intraperitoneal injection of the normal enzyme. 
A)  frequent colonoscopies. 
B)  a colectomy. 
C)  gene-replacement therapy. 
D)  an intraperitoneal injection of the normal enzyme.

Question 11

Which statement regarding somatic hypermutation is false?

Accepted Answer

A)  The enzyme activation-induced deaminase (AI
D)  is a key player in somatic hypermutation. 
B)  Somatic hypermutation is thought to be the result of a high frequency of errors during DNA repair. 
C)  Somatic hypermutation is thought to control the proliferation of B lymphocytes by rendering their genome nonreplicable. 
D)  Somatic hypermutation substantially increases affinity for antigen. 
A)  The enzyme activation-induced deaminase (AI
D)  is a key player in somatic hypermutation. 
B)  Somatic hypermutation is thought to be the result of a high frequency of errors during DNA repair. 
C)  Somatic hypermutation is thought to control the proliferation of B lymphocytes by rendering their genome nonreplicable. 
D)  Somatic hypermutation substantially increases affinity for antigen.

Question 12

Describe the AP site that is generated by the action of DNA glycosylase.

Accepted Answer

DNA glycosylase initiates the repair mec

Question 13

Free rotation of one cut DNA strand around one uncut strand is the primary function of

Accepted Answer

A)  topoisomerase I. 
B)  topoisomerase II. 
C)  DNA helicase. 
D)  DNA polymerase. 
A)  topoisomerase I. 
B)  topoisomerase II. 
C)  DNA helicase. 
D)  DNA polymerase.

Question 14

How many replication origins are there in the human genome?

Accepted Answer

A)  1 
B)  350 
C)  30,000 
D)  350,000 
A)  1 
B)  350 
C)  30,000 
D)  350,000

Question 15

Telomerase carries its own template DNA.

Accepted Answer

A) True 
 B)False

Question 16

DNA glycosylase can give rise to apyrimidinic and apurinic sites by cleaving bases from their deoxyribose on the DNA backbone.

Accepted Answer

A) True 
 B)False

Question 17

Double-stranded breaks are repaired by

Accepted Answer

A)  direct reversal of DNA damage. 
B)  translesion repair. 
C)  excision repair. 
D)  recombinational repair. 
A)  direct reversal of DNA damage. 
B)  translesion repair. 
C)  excision repair. 
D)  recombinational repair.

Question 18

Mutation in the MutS gene is most commonly associated with

Accepted Answer

A)  colorectal cancer. 
B)  melanoma. 
C)  squamous cell carcinoma of the skin. 
D)  small-cell carcinoma. 
A)  colorectal cancer. 
B)  melanoma. 
C)  squamous cell carcinoma of the skin. 
D)  small-cell carcinoma.

Question 19

Telomerase is

Accepted Answer

A)  a reverse transcriptase. 
B)  the enzyme that adds a random sequence to the ends of chromosomes. 
C)  an enzyme first discovered in Thermus aquaticus. 
D)  An enzyme that breaks down DNA from the ends. 
A)  a reverse transcriptase. 
B)  the enzyme that adds a random sequence to the ends of chromosomes. 
C)  an enzyme first discovered in Thermus aquaticus. 
D)  An enzyme that breaks down DNA from the ends.

Question 20

Which statement concerning elongation of DNA at the replication fork is false?

Accepted Answer

A)  The leading strand is synthesized continuously in the direction of replication fork movement. 
B)  The lagging strand is synthesized in Okazaki fragments backward from the overall direction of replication. 
C)  The Okazaki fragments are joined by the action of DNA ligase. 
D)  Both strands are synthesized continuously at the replication fork. 
A)  The leading strand is synthesized continuously in the direction of replication fork movement. 
B)  The lagging strand is synthesized in Okazaki fragments backward from the overall direction of replication. 
C)  The Okazaki fragments are joined by the action of DNA ligase. 
D)  Both strands are synthesized continuously at the replication fork.

What type of DNA damage would you expect to occur more frequently in populations as they near the equator?

The genes that encode the immunoglobulin light chain consist of regions that are called ___, _, and _____.

Though not a common mechanism, gene amplification is used by cells to rapidly give rise to multiple copies of mRNAs to meet large demands for particular proteins. How is gene amplification accomplished? Give an example of when a cell may activate this process.

Deamination of cytosine results in the conversion of cytosine to

The BRCA genes responsible for inherited breast cancer are involved in the repair of _______ DNA breaks by homologous recombination.

In addition to synthesizing DNA, DNA polymerase I has a second catalytic activity: it can

The rate of DNA replication in mammalian cells is tenfold faster than in prokaryotic cells.

Which statement about gene amplification is false?

During mismatch repair in E. coli, the parental strand is recognized by

Patients with hereditary nonpolyposis colorectal cancer genes should have

Which statement regarding somatic hypermutation is false?

Describe the AP site that is generated by the action of DNA glycosylase.

Free rotation of one cut DNA strand around one uncut strand is the primary function of

How many replication origins are there in the human genome?

Telomerase carries its own template DNA.

DNA glycosylase can give rise to apyrimidinic and apurinic sites by cleaving bases from their deoxyribose on the DNA backbone.

Double-stranded breaks are repaired by

Mutation in the MutS gene is most commonly associated with

Telomerase is

Which statement concerning elongation of DNA at the replication fork is false?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Exam 7: Replication, Maintenance, and Rearrangements of Genomic Dna

What type of DNA damage would you expect to occur more frequently in populations as they near the equator?

The genes that encode the immunoglobulin light chain consist of regions that are called _______, _______, and _______.

Though not a common mechanism, gene amplification is used by cells to rapidly give rise to multiple copies of mRNAs to meet large demands for particular proteins. How is gene amplification accomplished? Give an example of when a cell may activate this process.

Deamination of cytosine results in the conversion of cytosine to

The BRCA genes responsible for inherited breast cancer are involved in the repair of _______ DNA breaks by homologous recombination.

In addition to synthesizing DNA, DNA polymerase I has a second catalytic activity: it can

The rate of DNA replication in mammalian cells is tenfold faster than in prokaryotic cells.

Which statement about gene amplification is false?

During mismatch repair in E. coli, the parental strand is recognized by

Patients with hereditary nonpolyposis colorectal cancer genes should have

Which statement regarding somatic hypermutation is false?

Describe the AP site that is generated by the action of DNA glycosylase.

Free rotation of one cut DNA strand around one uncut strand is the primary function of

How many replication origins are there in the human genome?

Telomerase carries its own template DNA.

DNA glycosylase can give rise to apyrimidinic and apurinic sites by cleaving bases from their deoxyribose on the DNA backbone.

Double-stranded breaks are repaired by

Mutation in the MutS gene is most commonly associated with

Telomerase is

Which statement concerning elongation of DNA at the replication fork is false?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

The genes that encode the immunoglobulin light chain consist of regions that are called ___, _, and _____.