Exam 24: Tumor Markers

A new tumor marker assay for prostate specific antigen (PSA) is evaluated for diagnostic sensitivity by testing serum samples from patients who have been diagnosed as having prostate cancer. The following results were obtained: Number of prostate cancer patients who tested positive by the new assay = 42 out 46 Number of patients who did not have cancer and tested negative by the new assay = 31 out of 32 What is the sensitivity of the new assay for PSA?

A new test for breast cancer is found to have a sensitivity of 85.0% and a specificity of 90.0%. If the prevalence of breast cancer is 3.5% in women over 45 years old, what is the predictive value of a positive test result (PV+) in this group?

Which of the following assays is recommended as a screening test for colorectal cancer in persons over 50 years of age?

The combination of squamous cell carcinoma antigen (SCCA) and CYFRA 21-1 test results can be used to provide reliable laboratory data for the differential diagnosis of which disease?

Which type of hCG test would be most useful to assess a person suspected of having testicular cancer?

Which tumor marker is associated with cancer of the urinary bladder?

Which statement below best describes the molecular difference between free PSA (fPSA) and complex PSA (cPSA)?

Which of the following biomarkers are elevated in advanced stages of breast cancer?

The production of alpha fetal protein (AFP) in a healthy individual is best reflected by which of the following statements?

Which of the following is a sialylated Lewis blood group antigen associated with colorectal cancer?

Diagnostic specificity is defined as which of the following?

What is the clinical usefulness of measuring carcinoembryonic antigen?

A markedly elevated serum AFP is associated with which of the following?

Nuclear matrix protein-22 (NMP) is a tumor marker designed for what purpose?

Which of the following statement is correct about PSA?

Which of the following must be determined to calculate diagnostic specificity?

In which of the following disorders would the maternal serum level of ?₁-fetoprotein be elevated?

Which of the following is used to assess the usefulness of trastuzumab (Herceptin) therapy for breast cancer?

Which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer?

Which molecular form(s) is/are measured by an intact ?-hCG assay?