Question 1

A person with Menke's syndrome will have which of the following laboratory results?

Accepted Answer

A)  Decreased blood arsenic 
B)  Increased blood zinc 
C)  Increased blood copper 
D)  Decreased blood copper 
A)  Decreased blood arsenic 
B)  Increased blood zinc 
C)  Increased blood copper 
D)  Decreased blood copper D

Question 2

Imiprimine is classified as:

Accepted Answer

A)  Tetracyclic aminoglycosides. 
B)  Tricyclic antidepressant. 
C)  An opioid. 
D)  Antiepileptic. 
A)  Tetracyclic aminoglycosides. 
B)  Tricyclic antidepressant. 
C)  An opioid. 
D)  Antiepileptic. B

Question 3

Which of the following metals is an example of a trace metal?

Accepted Answer

A)  Potassium 
B)  Cobalt 
C)  Calcium 
D)  Magnesium 
A)  Potassium 
B)  Cobalt 
C)  Calcium 
D)  Magnesium B

Question 4

Which of the following substances when ingested can lead to an excessive amount of aluminum in blood and tissue?

Accepted Answer

A)  Antacids and astringents 
B)  Wine 
C)  Aspirin 
D)  Citrus fruit 
A)  Antacids and astringents 
B)  Wine 
C)  Aspirin 
D)  Citrus fruit

Question 5

What is the primary route of exposure in humans to mercury?

Accepted Answer

A)  Inhalation of vapors 
B)  Contact with the skin of metalal mercury (e.g., mercury containing thermometers) 
C)  Ingestion of mercury containing medications 
D)  Direct injection of mercury from contaminated needles 
A)  Inhalation of vapors 
B)  Contact with the skin of metalal mercury (e.g., mercury containing thermometers) 
C)  Ingestion of mercury containing medications 
D)  Direct injection of mercury from contaminated needles

Question 6

The toxic effect of acetaminophen overdose is:

Accepted Answer

A)  Cardiac arrest. 
B)  Hepatocystic necrosis. 
C)  Renal necrosis. 
D)  Hypotension. 
A)  Cardiac arrest. 
B)  Hepatocystic necrosis. 
C)  Renal necrosis. 
D)  Hypotension.

Question 7

THC (?9-tetrahydrocannabinol) is the principal active metabolite of which of the following?

Accepted Answer

A)  Benzodiazepine 
B)  Marijuana 
C)  Acetaminophen 
D)  Morphine 
A)  Benzodiazepine 
B)  Marijuana 
C)  Acetaminophen 
D)  Morphine

Question 8

Possible risks of hepatocellular damage due to toxic blood levels of acetaminophen are evaluated based on blood levels and which of the following?

Accepted Answer

A)  Urine levels 
B)  Months post ingestion 
C)  Time (hours) post ingestion 
D)  Degree of level of consciousness (LO
C)  
A)  Urine levels 
B)  Months post ingestion 
C)  Time (hours) post ingestion 
D)  Degree of level of consciousness (LO
C)

Question 9

Which of the following trace metals is classified as essential?

Accepted Answer

A)  Mercury 
B)  Silver 
C)  Chromium 
D)  Cobalt 
A)  Mercury 
B)  Silver 
C)  Chromium 
D)  Cobalt

Question 10

Aceruoplasminemia is associated with which of the following?

Accepted Answer

A)  Decreased blood ceruloplasmin, increased copper deposition in the liver, and increased zinc deposition in tissues 
B)  Decreased blood ceruloplasmin, decreased copper deposition in the liver, and increased iron deposition in tissues 
C)  Increased blood ceruloplasmin, increased copper deposition in the liver, and increased iron deposition in tissues 
D)  Decreased blood ceruloplasmin, increased copper deposition in the liver, and increased iron deposition in tissues 
A)  Decreased blood ceruloplasmin, increased copper deposition in the liver, and increased zinc deposition in tissues 
B)  Decreased blood ceruloplasmin, decreased copper deposition in the liver, and increased iron deposition in tissues 
C)  Increased blood ceruloplasmin, increased copper deposition in the liver, and increased iron deposition in tissues 
D)  Decreased blood ceruloplasmin, increased copper deposition in the liver, and increased iron deposition in tissues

Question 11

Which of the following cytochromes plays a major role in the metabolism of drugs in the liver?

Accepted Answer

A)  Cytochrome P650 
B)  Cytochrome P490 
C)  Cytochrome P250 
D)  Cytochrome P450 
A)  Cytochrome P650 
B)  Cytochrome P490 
C)  Cytochrome P250 
D)  Cytochrome P450

Question 12

The reason that carbon monoxide is so toxic is because it:

Accepted Answer

A)  Is a protoplasmic poison. 
B)  Combines with cytochrome oxidase. 
C)  Has 200-250 times the affinity of oxygen for hemoglobin binding sites. 
D)  Sensitizes the myocardium. 
A)  Is a protoplasmic poison. 
B)  Combines with cytochrome oxidase. 
C)  Has 200-250 times the affinity of oxygen for hemoglobin binding sites. 
D)  Sensitizes the myocardium.

Question 13

Which of the following sets of laboratory results is associated with Wilson's disease?

Accepted Answer

A)  Decreased plasma copper and plasma ceruloplasmin 
B)  Decreased plasma copper and increased plasma ceruloplasmin 
C)  Increased plasma copper and decreased plasma ceruloplasmin 
D)  Increased plasma copper and increased plasma ceruloplasmin 
A)  Decreased plasma copper and plasma ceruloplasmin 
B)  Decreased plasma copper and increased plasma ceruloplasmin 
C)  Increased plasma copper and decreased plasma ceruloplasmin 
D)  Increased plasma copper and increased plasma ceruloplasmin

Question 14

Levels of 89% carboxyhemoglobin saturation of whole blood are commonly found in which of the following?

Accepted Answer

A)  Fatal carbon monoxide poisoning 
B)  Nonsmoking residents who live in the country 
C)  Nonsmoking residents of large cities 
D)  Cigarette smokers 
A)  Fatal carbon monoxide poisoning 
B)  Nonsmoking residents who live in the country 
C)  Nonsmoking residents of large cities 
D)  Cigarette smokers

Question 15

Berylliosis in humans affects which of the following organs?

Accepted Answer

A)  Brain 
B)  Heart 
C)  Urinary bladder 
D)  Lungs 
A)  Brain 
B)  Heart 
C)  Urinary bladder 
D)  Lungs

Question 16

Ethanol metabolizes to which of the following acids?

Accepted Answer

A)  Formic 
B)  Acetic 
C)  Glycolic 
D)  Hydrochloric 
A)  Formic 
B)  Acetic 
C)  Glycolic 
D)  Hydrochloric

Question 17

Which of the following has a large amount of aluminum present?

Accepted Answer

A)  Baking soda 
B)  Saline 
C)  Antacids 
D)  Radiator fluid 
A)  Baking soda 
B)  Saline 
C)  Antacids 
D)  Radiator fluid

Question 18

Antimony is used to treat patients with which disorder?

Accepted Answer

A)  Diabetes 
B)  Pneumonia 
C)  Schistosomiasis 
D)  Lupus erythematosus 
A)  Diabetes 
B)  Pneumonia 
C)  Schistosomiasis 
D)  Lupus erythematosus

Question 19

Screening methods for drug abuse testing requires which of the following assay characteristics?

Accepted Answer

A)  They must be very specific. 
B)  They must be analytically sensitive. 
C)  They must be free of interferences. 
D)  They must be very accurate. 
A)  They must be very specific. 
B)  They must be analytically sensitive. 
C)  They must be free of interferences. 
D)  They must be very accurate.

Question 20

Chromium in blood binds to which of the following proteins?

Accepted Answer

A)  Chromodulin 
B)  Chromoglobulin 
C)  Microalbumin 
D)  Glucuronide 
A)  Chromodulin 
B)  Chromoglobulin 
C)  Microalbumin 
D)  Glucuronide

Exam 22: Toxic Substances

A person with Menke's syndrome will have which of the following laboratory results?

Imiprimine is classified as:

Which of the following metals is an example of a trace metal?

Which of the following substances when ingested can lead to an excessive amount of aluminum in blood and tissue?

What is the primary route of exposure in humans to mercury?

The toxic effect of acetaminophen overdose is:

THC (?9-tetrahydrocannabinol) is the principal active metabolite of which of the following?

Possible risks of hepatocellular damage due to toxic blood levels of acetaminophen are evaluated based on blood levels and which of the following?

Which of the following trace metals is classified as essential?

Aceruoplasminemia is associated with which of the following?

Which of the following cytochromes plays a major role in the metabolism of drugs in the liver?

The reason that carbon monoxide is so toxic is because it:

Which of the following sets of laboratory results is associated with Wilson's disease?

Levels of 89% carboxyhemoglobin saturation of whole blood are commonly found in which of the following?

Berylliosis in humans affects which of the following organs?

Ethanol metabolizes to which of the following acids?

Which of the following has a large amount of aluminum present?

Antimony is used to treat patients with which disorder?

Screening methods for drug abuse testing requires which of the following assay characteristics?

Chromium in blood binds to which of the following proteins?

Laboratory Basics

Safety in the Clinical Chemistry Laboratory

Laboratory Statistics, Method Development and QC

Instrumentation, Laboratory Automation, and Informatics

Immunoassays

Molecular Diagnostics

Carbohydrates

Lipids

Proteins

Enzymes

Nonprotein Nitrogen Questions

Body Water and Electrolyte Homeostasis

Blood Gases, PH, and Acid-Base Balance

Mineral and Bone Metabolism

The Endocrine System

Gastrointestinal Function

Pancreas

Cardiac Function

Liver

Iron, Porphyrins, and Hemoglobin

Therapeutic Drug Monitoring

Nutrition and Vitamins

Tumor Markers

Geriatrics

Pediatrics

Filters

THC (?⁹-tetrahydrocannabinol) is the principal active metabolite of which of the following?