Question 1

Which of the following is an example of an antiarrhythmic drug that has a metabolite with very similar same pharmacological action?

Accepted Answer

A)  Procainamide 
B)  Phenobarbital 
C)  Quinidine 
D)  Caffeine 
A)  Procainamide 
B)  Phenobarbital 
C)  Quinidine 
D)  Caffeine A

Question 2

Plasma clearance of a drug is defined as:

Accepted Answer

A)  The volume of plasma from which all drug appears to be removed in a given volume of blood (e.g., mL/mL). 
B)  The volume of plasma from which all drug appears to be removed in a given time (e.g., mL/min). 
C)  The amount of drug removed from urine in a given time (e.g., mg/min). 
D)  The amount of time it takes for a drug to reach seven half-lives. 
A)  The volume of plasma from which all drug appears to be removed in a given volume of blood (e.g., mL/mL). 
B)  The volume of plasma from which all drug appears to be removed in a given time (e.g., mL/min). 
C)  The amount of drug removed from urine in a given time (e.g., mg/min). 
D)  The amount of time it takes for a drug to reach seven half-lives. B

Question 3

Phenobarbital is classified as a (an):

Accepted Answer

A)  Cardiac glycoside. 
B)  Anti arrhythmic. 
C)  Analgesic, antipyretic, and anti-inflammatory. 
D)  Sedative and hypnotic. 
A)  Cardiac glycoside. 
B)  Anti arrhythmic. 
C)  Analgesic, antipyretic, and anti-inflammatory. 
D)  Sedative and hypnotic. D

Question 4

Which of the following are the toxic effects of phenobarbital?

Accepted Answer

A)  Atrial fibrillation, hyperactive, and very fast breathing rates 
B)  Severe tiredness/dizziness, inability to wake up, and very slow breathing rates 
C)  Ototoxicity and possible nephrotoxicity 
D)  Spontaneous hemorrhage or life-threatening infections 
A)  Atrial fibrillation, hyperactive, and very fast breathing rates 
B)  Severe tiredness/dizziness, inability to wake up, and very slow breathing rates 
C)  Ototoxicity and possible nephrotoxicity 
D)  Spontaneous hemorrhage or life-threatening infections

Question 5

Steady state of a drug is typically achieved after:

Accepted Answer

A)  Approximately seven half-lives. 
B)  Approximately two half-lives. 
C)  The drug is completely absorbed from the gut. 
D)  The drug first begins to appear in the urine. 
A)  Approximately seven half-lives. 
B)  Approximately two half-lives. 
C)  The drug is completely absorbed from the gut. 
D)  The drug first begins to appear in the urine.

Question 6

Which of the following compounds is a cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction?

Accepted Answer

A)  Digoxin 
B)  Carbamazepine 
C)  Amikacin 
D)  Phenobarbital 
A)  Digoxin 
B)  Carbamazepine 
C)  Amikacin 
D)  Phenobarbital

Question 7

Clearance (CL) of a drug is defined as which of the following?

Accepted Answer

A)  The rate of elimination by all routes normalized to the concentration of drug, in some biological fluids 
B)  A measure of the apparent space the body has available to contain the drug 
C)  The time required for an amount of drug in blood to decline to one-half its measured value 
D)  The fraction of drug dose reaching the systemic circulation following administration by any route 
A)  The rate of elimination by all routes normalized to the concentration of drug, in some biological fluids 
B)  A measure of the apparent space the body has available to contain the drug 
C)  The time required for an amount of drug in blood to decline to one-half its measured value 
D)  The fraction of drug dose reaching the systemic circulation following administration by any route

Question 8

Which of the following compounds selectively inhibits proliferation and activation of CD4+ T cells?

Accepted Answer

A)  Digoxin 
B)  Beta hCG 
C)  Progesterone 
D)  Cyclosporine A 
A)  Digoxin 
B)  Beta hCG 
C)  Progesterone 
D)  Cyclosporine A

Question 9

Carbamazepine, primidone, and valproic acid are all examples of:

Accepted Answer

A)  Antiarrhythmic drugs. 
B)  Antidepressant drug. 
C)  Antibiotics. 
D)  Antiepileptic drugs. 
A)  Antiarrhythmic drugs. 
B)  Antidepressant drug. 
C)  Antibiotics. 
D)  Antiepileptic drugs.

Question 10

The fractional extent to which a dose of drug reaches its site of action is referred to as:

Accepted Answer

A)  Elimination half-life. 
B)  Phase I reaction. 
C)  First- pass effect. 
D)  Bioavailability. 
A)  Elimination half-life. 
B)  Phase I reaction. 
C)  First- pass effect. 
D)  Bioavailability.

Question 11

Which of the following is bactericidal for Streptococci, Corynebacterium, Clostridia, Listeria, and Bacillus species?

Accepted Answer

A)  Tobramycin 
B)  Cyclosporine 
C)  Vancomycin 
D)  Methotrexate 
A)  Tobramycin 
B)  Cyclosporine 
C)  Vancomycin 
D)  Methotrexate

Question 12

The pharmacological response of a drug is initiated when the drug is in which form?

Accepted Answer

A)  Bound to fatty acids 
B)  Bound to proteins 
C)  Bound to carbohydrates 
D)  Free 
A)  Bound to fatty acids 
B)  Bound to proteins 
C)  Bound to carbohydrates 
D)  Free

Question 13

Which of the following compounds is the major metabolite of primidone?

Accepted Answer

A)  Digoxin 
B)  Theophylline 
C)  N-acetylprocainamide 
D)  Phenobarbital 
A)  Digoxin 
B)  Theophylline 
C)  N-acetylprocainamide 
D)  Phenobarbital

Question 14

A drug that is administered into the subarachnoid space or ventricles (intrathecal) is referred to as:

Accepted Answer

A)  Oral. 
B)  Topical. 
C)  Parenteral. 
D)  Enteral. 
A)  Oral. 
B)  Topical. 
C)  Parenteral. 
D)  Enteral.

Question 15

Depakene or Depakote are proprietary names for which of the following compounds?

Accepted Answer

A)  Phenobarbital 
B)  Dilantin 
C)  Valproic acid 
D)  Carbamazepine 
A)  Phenobarbital 
B)  Dilantin 
C)  Valproic acid 
D)  Carbamazepine

Question 16

The goal of therapeutic drug monitoring (TDM) is to:

Accepted Answer

A)  Provide the patient with the least amount of drug to effect the best outcome. 
B)  Provide the patient with the cheapest formulation of the drug to effect the best outcome. 
C)  Provide the patient with the best estimate of a dosage of drug to effect the best outcome. 
D)  Provide the patient with the optimum dosage of drug to effect the best outcome. 
A)  Provide the patient with the least amount of drug to effect the best outcome. 
B)  Provide the patient with the cheapest formulation of the drug to effect the best outcome. 
C)  Provide the patient with the best estimate of a dosage of drug to effect the best outcome. 
D)  Provide the patient with the optimum dosage of drug to effect the best outcome.

Question 17

Which of the following best reflect the four correct pharmacological parameters that determine serum drug concentration?

Accepted Answer

A)  Absorption, anabolism, bioactivation, excretion 
B)  Equilibration, biotransformation, reabsorption, elimination 
C)  Absorption, distribution, metabolism, excretion 
D)  Ingestion, conjugation, metabolism, elimination 
A)  Absorption, anabolism, bioactivation, excretion 
B)  Equilibration, biotransformation, reabsorption, elimination 
C)  Absorption, distribution, metabolism, excretion 
D)  Ingestion, conjugation, metabolism, elimination

Question 18

Phase I biotransformation includes:

Accepted Answer

A)  Attachment of a hydroxyl group. 
B)  Conjugation with glucuronic acid. 
C)  Conjugation with sulfate. 
D)  Conjugation with glutathione. 
A)  Attachment of a hydroxyl group. 
B)  Conjugation with glucuronic acid. 
C)  Conjugation with sulfate. 
D)  Conjugation with glutathione.

Question 19

Which of the following compounds relaxes the smooth muscles of the bronchial passages?

Accepted Answer

A)  Acetaminophen 
B)  Lithium 
C)  Phenytoin 
D)  Theophylline 
A)  Acetaminophen 
B)  Lithium 
C)  Phenytoin 
D)  Theophylline

Question 20

A blood sample for a trough drug level should be drawn:

Accepted Answer

A)  During the distribution phase of the drug. 
B)  1.5 hours after drug administration. 
C)  Shortly before drug administration. 
D)  During phase I biotransformation. 
A)  During the distribution phase of the drug. 
B)  1.5 hours after drug administration. 
C)  Shortly before drug administration. 
D)  During phase I biotransformation.

Exam 21: Therapeutic Drug Monitoring

Which of the following is an example of an antiarrhythmic drug that has a metabolite with very similar same pharmacological action?

Plasma clearance of a drug is defined as:

Phenobarbital is classified as a (an):

Which of the following are the toxic effects of phenobarbital?

Steady state of a drug is typically achieved after:

Which of the following compounds is a cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction?

Clearance (CL) of a drug is defined as which of the following?

Which of the following compounds selectively inhibits proliferation and activation of CD4+ T cells?

Carbamazepine, primidone, and valproic acid are all examples of:

The fractional extent to which a dose of drug reaches its site of action is referred to as:

Which of the following is bactericidal for Streptococci, Corynebacterium, Clostridia, Listeria, and Bacillus species?

The pharmacological response of a drug is initiated when the drug is in which form?

Which of the following compounds is the major metabolite of primidone?

A drug that is administered into the subarachnoid space or ventricles (intrathecal) is referred to as:

Depakene or Depakote are proprietary names for which of the following compounds?

The goal of therapeutic drug monitoring (TDM) is to:

Which of the following best reflect the four correct pharmacological parameters that determine serum drug concentration?

Phase I biotransformation includes:

Which of the following compounds relaxes the smooth muscles of the bronchial passages?

A blood sample for a trough drug level should be drawn:

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