Question 1

Why is the determination of the D antigen important for women during pregnancy?

Accepted Answer

A)  A D-positive mother can form anti-D during pregnancy that may destroy the D-positive red cells of the fetus. 
B)  A D-negative mother should be given Rh Immune Globulin to prevent potential formation of anti-D during delivery of a D-positive infant. 
C)  A D-negative mother may form anti-D if the father of the child is also D-negative. 
D)  A D-positive mother may pass her red cells to the D-negative fetus and cause hemolytic disease of the fetus and newborn. 
A)  A D-positive mother can form anti-D during pregnancy that may destroy the D-positive red cells of the fetus. 
B)  A D-negative mother should be given Rh Immune Globulin to prevent potential formation of anti-D during delivery of a D-positive infant. 
C)  A D-negative mother may form anti-D if the father of the child is also D-negative. 
D)  A D-positive mother may pass her red cells to the D-negative fetus and cause hemolytic disease of the fetus and newborn. B

Question 2

Match the Fisher-Race notation with the correct Weiner notation for the following:
-ry

Accepted Answer

A) Ce 
B) CE 
C) DCE 
D) Dce 
A) Ce 
B) CE 
C) DCE 
D) Dce B

Question 3

Current theory regarding the genetics of the Rh system suggests that:

Accepted Answer

A)  each Rh system antigen is coded by its own gene locus. 
B)  Rh system antigens are coded by two closely linked genes. 
C)  one gene locus with multiple alleles codes for the protein antigens. 
D)  the Rh system genes are a haplotype that codes for three sets of alleles. 
A)  each Rh system antigen is coded by its own gene locus. 
B)  Rh system antigens are coded by two closely linked genes. 
C)  one gene locus with multiple alleles codes for the protein antigens. 
D)  the Rh system genes are a haplotype that codes for three sets of alleles. B

Question 4

How is it genetically possible for a child to phenotype as D-negative?

Accepted Answer

A)  Both parents are heterozygous D-positive. 
B)  Both parents are homozygous D-positive. 
C)  Mom is homozygous D-positive, and Dad is heterozygous D-positive. 
D)  The sibling is D-positive. 
A)  Both parents are heterozygous D-positive. 
B)  Both parents are homozygous D-positive. 
C)  Mom is homozygous D-positive, and Dad is heterozygous D-positive. 
D)  The sibling is D-positive.

Question 5

How would a donor who tested negative with anti-D reagent in the immediate spin test but positive at antihuman globulin with anti-D reagent be labeled?

Accepted Answer

A)  D-positive 
B)  D-negative 
A)  D-positive 
B)  D-negative

Question 6

Most Rh system antibodies are of which immunoglobulin class?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE 
A)  IgM 
B)  IgG 
C)  IgA 
D)  IgE

Question 7

Match the following phenotypes with the most probable genotype in the Weiner nomenclature.
-DcE

Accepted Answer

A) R1r 
B) R1R1 
C) R2R2 
D) rr 
A) R1r 
B) R1R1 
C) R2R2 
D) rr

Question 8

The inheritance of the Rh antigens are:

Accepted Answer

A)  X-linked recessive. 
B)  X-linked dominant. 
C)  autosomal recessive. 
D)  codominant. 
A)  X-linked recessive. 
B)  X-linked dominant. 
C)  autosomal recessive. 
D)  codominant.

Question 9

Match the Fisher-Race notation with the correct Weiner notation for the following:
-Rz

Accepted Answer

A) Ce 
B) CE 
C) DCE 
D) Dce 
A) Ce 
B) CE 
C) DCE 
D) Dce

Question 10

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

Accepted Answer

A)  C 
B)  c 
C)  e 
D)  E 
A)  C 
B)  c 
C)  e 
D)  E

Question 11

The frequency of the D-negative phenotype in the population is:

Accepted Answer

A)  15%. 
B)  85%. 
C)  50%. 
D)  35%. 
A)  15%. 
B)  85%. 
C)  50%. 
D)  35%.

Question 12

Which of the following phenotypes will react with anti-f?

Accepted Answer

A)  rr 
B)  R1R1 
C)  R2R2 
D)  R1R2 
A)  rr 
B)  R1R1 
C)  R2R2 
D)  R1R2

Question 13

Red cells that phenotype as D-negative indicate that:

Accepted Answer

A)  they inherited two D genes. 
B)  there is no genetic material inherited from the RHD gene from both parents. 
C)  a suppressor gene was inherited that is turning off the D gene expression. 
D)  reagents currently in use are not detecting the D antigen. 
A)  they inherited two D genes. 
B)  there is no genetic material inherited from the RHD gene from both parents. 
C)  a suppressor gene was inherited that is turning off the D gene expression. 
D)  reagents currently in use are not detecting the D antigen.

Question 14

Anti-D reagent and the Rh control were tested with red cells. Both tests were 2+ agglutination reactions. What is the interpretation of the results?

Accepted Answer

A)  D-positive 
B)  D-negative 
C)  Unable to interpret without further testing 
D)  D-positive if the sample is from a patient 
A)  D-positive 
B)  D-negative 
C)  Unable to interpret without further testing 
D)  D-positive if the sample is from a patient

Question 15

All of the following can cause the D antigen expression to be weaker except:

Accepted Answer

A)  inheriting the G gene. 
B)  inheriting the C antigen in trans to the D antigen. 
C)  an RHD gene that is genetically weaker. 
D)  partial D expression. 
A)  inheriting the G gene. 
B)  inheriting the C antigen in trans to the D antigen. 
C)  an RHD gene that is genetically weaker. 
D)  partial D expression.

Question 16

The weak D test detects:

Accepted Answer

A)  the Du antigen. 
B)  the missing D mosaic. 
C)  a weak D antibody. 
D)  a weak D antigen. 
A)  the Du antigen. 
B)  the missing D mosaic. 
C)  a weak D antibody. 
D)  a weak D antigen.

Question 17

The LW antigen expression is typically stronger on __________ cells.

Accepted Answer

A)  D-positive red 
B)  D-negative red 
C)  Rh null 
D)  D-variant 
A)  D-positive red 
B)  D-negative red 
C)  Rh null 
D)  D-variant

Question 18

Match the Fisher-Race notation with the correct Weiner notation for the following:
-R0

Accepted Answer

A) Ce 
B) CE 
C) DCE 
D) Dce 
A) Ce 
B) CE 
C) DCE 
D) Dce

Question 19

A patient phenotypes as D+C+E-c-e+. The most likely genotype is:

Accepted Answer

A)  R1r. 
B)  R1R1. 
C)  R1r'. 
D)  R1R0. 
A)  R1r. 
B)  R1R1. 
C)  R1r'. 
D)  R1R0.

Question 20

Each of the following genotypes is possible for an individual whose red cells react as indicated below except:

Accepted Answer

A)  R1R2 
B)  R1r" 
C)  Rzr 
D)  R0r' 
A)  R1R2 
B)  R1r" 
C)  Rzr 
D)  R0r'

Why is the determination of the D antigen important for women during pregnancy?

Match the Fisher-Race notation with the correct Weiner notation for the following: -r^y

Current theory regarding the genetics of the Rh system suggests that:

How is it genetically possible for a child to phenotype as D-negative?

How would a donor who tested negative with anti-D reagent in the immediate spin test but positive at antihuman globulin with anti-D reagent be labeled?

Most Rh system antibodies are of which immunoglobulin class?

Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DcE

The inheritance of the Rh antigens are:

Match the Fisher-Race notation with the correct Weiner notation for the following: -R^z

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

The frequency of the D-negative phenotype in the population is:

Which of the following phenotypes will react with anti-f?

Red cells that phenotype as D-negative indicate that:

Anti-D reagent and the Rh control were tested with red cells. Both tests were 2+ agglutination reactions. What is the interpretation of the results?

All of the following can cause the D antigen expression to be weaker except:

The weak D test detects:

The LW antigen expression is typically stronger on __________ cells.

Match the Fisher-Race notation with the correct Weiner notation for the following: -R⁰

A patient phenotypes as D+C+E-c-e+. The most likely genotype is:

Each of the following genotypes is possible for an individual whose red cells react as indicated below except:

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications in Immunohematology

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry

Safety Issues in the Blood Bank

Filters

Exam 5: Rh Blood Group System

Why is the determination of the D antigen important for women during pregnancy?

Match the Fisher-Race notation with the correct Weiner notation for the following: -ry

Current theory regarding the genetics of the Rh system suggests that:

How is it genetically possible for a child to phenotype as D-negative?

How would a donor who tested negative with anti-D reagent in the immediate spin test but positive at antihuman globulin with anti-D reagent be labeled?

Most Rh system antibodies are of which immunoglobulin class?

Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DcE

The inheritance of the Rh antigens are:

Match the Fisher-Race notation with the correct Weiner notation for the following: -Rz

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

The frequency of the D-negative phenotype in the population is:

Which of the following phenotypes will react with anti-f?

Red cells that phenotype as D-negative indicate that:

Anti-D reagent and the Rh control were tested with red cells. Both tests were 2+ agglutination reactions. What is the interpretation of the results?

All of the following can cause the D antigen expression to be weaker except:

The weak D test detects:

The LW antigen expression is typically stronger on __________ cells.

Match the Fisher-Race notation with the correct Weiner notation for the following: -R0

A patient phenotypes as D+C+E-c-e+. The most likely genotype is:

Each of the following genotypes is possible for an individual whose red cells react as indicated below except:

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications in Immunohematology

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry

Safety Issues in the Blood Bank

Filters

Match the Fisher-Race notation with the correct Weiner notation for the following: -r^y

Match the Fisher-Race notation with the correct Weiner notation for the following: -R^z

Match the Fisher-Race notation with the correct Weiner notation for the following: -R⁰