Question 1

Select the situation where the administration of Rh immune globulin would be contraindicated. MOTHER NEWBORN

Accepted Answer

A)  r"r; no antibody detected Ror; direct antiglobulin test (DAT) negative 
B)  Rr; no antibody detected R1r; DAT negative 
C)  Rr; anti-E detected R2r; DAT positive 
D)  r"r; anti-D detected R2r: DAT positive 
A)  r"r; no antibody detected Ror; direct antiglobulin test (DAT) negative 
B)  Rr; no antibody detected R1r; DAT negative 
C)  Rr; anti-E detected R2r; DAT positive 
D)  r"r; anti-D detected R2r: DAT positive D

Question 2

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

Accepted Answer

A)  Anti-A,B 
B)  Anti-C 
C)  Anti-D 
D)  Anti-K 
A)  Anti-A,B 
B)  Anti-C 
C)  Anti-D 
D)  Anti-K A

Question 3

Anti-D in the serum of a third-trimester pregnant woman with a titer of 16 is indicative of:

Accepted Answer

A)  the presence of Rh immune globulin administered at 28 weeks. 
B)  active immunization. 
C)  passive immunization. 
D)  none of the above. 
A)  the presence of Rh immune globulin administered at 28 weeks. 
B)  active immunization. 
C)  passive immunization. 
D)  none of the above. B

Question 4

Rh immune globulin should be given within how many hours following delivery?

Accepted Answer

A)  12 
B)  24 
C)  48 
D)  72 
A)  12 
B)  24 
C)  48 
D)  72

Question 5

During a first-trimester prenatal examination, it was determined that a pregnant woman was group A, D-negative with an anti-D titer of 8. What is the most likely course of action?

Accepted Answer

A)  The anti-D is probably from prenatal Rh immune globulin and should be given another dose at birth. 
B)  The titer is significant if a rise in titer is detected. 
C)  The pregnancy is considered high risk, and the mother should be followed up immediately with amniocentesis or percutaneous umbilical cord testing. 
D)  None of the above. 
A)  The anti-D is probably from prenatal Rh immune globulin and should be given another dose at birth. 
B)  The titer is significant if a rise in titer is detected. 
C)  The pregnancy is considered high risk, and the mother should be followed up immediately with amniocentesis or percutaneous umbilical cord testing. 
D)  None of the above.

Question 6

Which of the following is true regarding the rosette test?

Accepted Answer

A)  It is a staining procedure that differentiates fetal and adult cells. 
B)  The test is valid only if the mother is D-negative and the infant is D-positive. 
C)  Indicator cells bind to the D-positive maternal cells forming a rosette. 
D)  The test is a quantitative test to determine how many vials of Rh immune globulin to administer. 
A)  It is a staining procedure that differentiates fetal and adult cells. 
B)  The test is valid only if the mother is D-negative and the infant is D-positive. 
C)  Indicator cells bind to the D-positive maternal cells forming a rosette. 
D)  The test is a quantitative test to determine how many vials of Rh immune globulin to administer.

Question 7

What immunoglobulin is capable of crossing the placenta?

Accepted Answer

A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE 
A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE

Question 8

A group O, D-positive mother gave birth to an A-negative infant. After 24 hours, the newborn's bilirubin level rose to 19 mg/dL. A direct antiglobulin test performed on the cord blood specimen was positive with anti-IgG. What is the most probable antibody causing this?

Accepted Answer

A)  Anti-D 
B)  Anti-A 
C)  Anti-B 
D)  Anti-A,B 
A)  Anti-D 
B)  Anti-A 
C)  Anti-B 
D)  Anti-A,B

Question 9

Rh immune globulin contains:

Accepted Answer

A)  IgG anti-D. 
B)  immune serum globulin. 
C)  IgM anti-D. 
D)  gamma globulin. 
A)  IgG anti-D. 
B)  immune serum globulin. 
C)  IgM anti-D. 
D)  gamma globulin.

Question 10

To be considered a candidate for Rh immune globulin, the mother is __________ and the infant is __________.

Accepted Answer

A)  D-positive, D-negative 
B)  D-negative, D-positive 
C)  D-negative, D-negative 
D)  D-positive, D-positive 
A)  D-positive, D-negative 
B)  D-negative, D-positive 
C)  D-negative, D-negative 
D)  D-positive, D-positive

Question 11

A newborn phenotypes as group O, D-positive with a 1+ direct antiglobulin test. The mother's antibody screening test is negative. Assuming the antibody screen is valid, one should consider hemolytic disease of the fetus and newborn due to an antibody against __________ antigen.

Accepted Answer

A)  D 
B)  A or B 
C)  low-incidence 
D)  high-incidence 
A)  D 
B)  A or B 
C)  low-incidence 
D)  high-incidence

Question 12

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph. Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature. Select the most appropriate decision regarding medical intervention.

Accepted Answer

A)  No immediate need for intervention 
B)  An intrauterine transfusion 
C)  Delivery by cesarean section 
D)  None of the above 
A)  No immediate need for intervention 
B)  An intrauterine transfusion 
C)  Delivery by cesarean section 
D)  None of the above

Question 13

To prevent graft-versus-host disease, red blood cells prepared for intrauterine transfusions should be:

Accepted Answer

A)  frozen and deglycerolized. 
B)  saline washed. 
C)  ABO and D-compatible with the mother. 
D)  irradiated. 
A)  frozen and deglycerolized. 
B)  saline washed. 
C)  ABO and D-compatible with the mother. 
D)  irradiated.

Question 14

An acid elution stain was made using a 1-hour postdelivery maternal blood sample. Results: 10 fetal cells/1000 cells counted
It is the policy to add 1 vial of Rh immune globulin to the calculated dose when the estimated volume of the hemorrhage exceeds 20 mL of whole blood. Calculate the number of vials of Rh immune globulin that would be indicated under these circumstances.

Accepted Answer

A)  2 
B)  3 
C)  4 
D)  5 
A)  2 
B)  3 
C)  4 
D)  5

Question 15

Which of the following antibodies have not been known to cause hemolytic disease of the fetus and newborn?

Accepted Answer

A)  Anti-C 
B)  Anti-K 
C)  Anti-Lea 
D)  Anti-S 
A)  Anti-C 
B)  Anti-K 
C)  Anti-Lea 
D)  Anti-S

Question 16

In testing amniotic fluid, the Liley method of predicting the severity of hemolytic disease of the fetus and newborn is based on:

Accepted Answer

A)  colorimetric protein analysis. 
B)  optical density of bilirubin at 450 nm. 
C)  ratio of lecithin to sphingomyelin. 
D)  titration of antibody. 
A)  colorimetric protein analysis. 
B)  optical density of bilirubin at 450 nm. 
C)  ratio of lecithin to sphingomyelin. 
D)  titration of antibody.

Question 17

A large fetomaternal bleed in a D-negative woman who delivered a D-positive infant should be suspected if the:

Accepted Answer

A)  direct antiglobulin test on the infant is positive. 
B)  infant is premature. 
C)  fetomaternal hemorrhage screen result is positive. 
D)  maternal antibody screen is positive postpartum. 
A)  direct antiglobulin test on the infant is positive. 
B)  infant is premature. 
C)  fetomaternal hemorrhage screen result is positive. 
D)  maternal antibody screen is positive postpartum.

Question 18

To identify the cause of suspected hemolytic disease of the fetus and newborn, which tests are performed?

Accepted Answer

A)  ABO group 
B)  D testing 
C)  Direct antiglobulin test 
D)  All of the above 
A)  ABO group 
B)  D testing 
C)  Direct antiglobulin test 
D)  All of the above

Question 19

Why is reverse grouping omitted in the neonatal period for ABO testing?

Accepted Answer

A)  The maternal antibody is identical to that of the newborn. 
B)  Newborns do not produce their own antibody until about 4 months. 
C)  The newborn's antibody is the same as the paternal antibody. 
D)  None of the above is correct. 
A)  The maternal antibody is identical to that of the newborn. 
B)  Newborns do not produce their own antibody until about 4 months. 
C)  The newborn's antibody is the same as the paternal antibody. 
D)  None of the above is correct.

Question 20

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Accepted Answer

A)  Glycine-acid 
B)  Freeze-thaw 
C)  Xylene 
D)  Chloroform 
A)  Glycine-acid 
B)  Freeze-thaw 
C)  Xylene 
D)  Chloroform

Select the situation where the administration of Rh immune globulin would be contraindicated. MOTHER NEWBORN

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

Anti-D in the serum of a third-trimester pregnant woman with a titer of 16 is indicative of:

Rh immune globulin should be given within how many hours following delivery?

During a first-trimester prenatal examination, it was determined that a pregnant woman was group A, D-negative with an anti-D titer of 8. What is the most likely course of action?

Which of the following is true regarding the rosette test?

What immunoglobulin is capable of crossing the placenta?

A group O, D-positive mother gave birth to an A-negative infant. After 24 hours, the newborn's bilirubin level rose to 19 mg/dL. A direct antiglobulin test performed on the cord blood specimen was positive with anti-IgG. What is the most probable antibody causing this?

Rh immune globulin contains:

To be considered a candidate for Rh immune globulin, the mother is and the infant is .

A newborn phenotypes as group O, D-positive with a 1+ direct antiglobulin test. The mother's antibody screening test is negative. Assuming the antibody screen is valid, one should consider hemolytic disease of the fetus and newborn due to an antibody against __________ antigen.

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph. Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature. Select the most appropriate decision regarding medical intervention.

To prevent graft-versus-host disease, red blood cells prepared for intrauterine transfusions should be:

Which of the following antibodies have not been known to cause hemolytic disease of the fetus and newborn?

In testing amniotic fluid, the Liley method of predicting the severity of hemolytic disease of the fetus and newborn is based on:

A large fetomaternal bleed in a D-negative woman who delivered a D-positive infant should be suspected if the:

To identify the cause of suspected hemolytic disease of the fetus and newborn, which tests are performed?

Why is reverse grouping omitted in the neonatal period for ABO testing?

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications in Immunohematology

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Adverse Complications of Transfusions

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry

Safety Issues in the Blood Bank

Filters

Exam 13: Hemolytic Disease of the Fetus and Newborn

Select the situation where the administration of Rh immune globulin would be contraindicated. MOTHER NEWBORN

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

Anti-D in the serum of a third-trimester pregnant woman with a titer of 16 is indicative of:

Rh immune globulin should be given within how many hours following delivery?

During a first-trimester prenatal examination, it was determined that a pregnant woman was group A, D-negative with an anti-D titer of 8. What is the most likely course of action?

Which of the following is true regarding the rosette test?

What immunoglobulin is capable of crossing the placenta?

A group O, D-positive mother gave birth to an A-negative infant. After 24 hours, the newborn's bilirubin level rose to 19 mg/dL. A direct antiglobulin test performed on the cord blood specimen was positive with anti-IgG. What is the most probable antibody causing this?

Rh immune globulin contains:

To be considered a candidate for Rh immune globulin, the mother is __________ and the infant is __________.

A newborn phenotypes as group O, D-positive with a 1+ direct antiglobulin test. The mother's antibody screening test is negative. Assuming the antibody screen is valid, one should consider hemolytic disease of the fetus and newborn due to an antibody against __________ antigen.

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph. Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature. Select the most appropriate decision regarding medical intervention.

To prevent graft-versus-host disease, red blood cells prepared for intrauterine transfusions should be:

Which of the following antibodies have not been known to cause hemolytic disease of the fetus and newborn?

In testing amniotic fluid, the Liley method of predicting the severity of hemolytic disease of the fetus and newborn is based on:

A large fetomaternal bleed in a D-negative woman who delivered a D-positive infant should be suspected if the:

To identify the cause of suspected hemolytic disease of the fetus and newborn, which tests are performed?

Why is reverse grouping omitted in the neonatal period for ABO testing?

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications in Immunohematology

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Adverse Complications of Transfusions

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry

Safety Issues in the Blood Bank

Filters

To be considered a candidate for Rh immune globulin, the mother is and the infant is .