Question 1

Which bones are affected in Legg-Calvé-Perthes disease?

Accepted Answer

A)  Heads of the femur 
B)  Distal femurs 
C)  Heads of the humerus 
D)  Distal tibias 
A)  Heads of the femur 
B)  Distal femurs 
C)  Heads of the humerus 
D)  Distal tibias

Question 2

If a child inherits facioscapulohumeral muscular dystrophy,she most likely inherited it from her:

Accepted Answer

A)  father. 
B)  mother. 
C)  affected parent. 
A)  father. 
B)  mother. 
C)  affected parent.

Question 3

MATCHING
Match the type of muscular dystrophy with its description.The types may be used more than once.
-Autosomal dominant with a slow rate of progression and frequent mental retardation

Accepted Answer

A) Duchenne muscular dystrophy 
B) Facioscapulohumeral muscular dystrophy 
C) Scapuloperoneal muscular dystrophy 
D) Myotonic dystrophy 
E) Becker muscular dystrophy 
A) Duchenne muscular dystrophy 
B) Facioscapulohumeral muscular dystrophy 
C) Scapuloperoneal muscular dystrophy 
D) Myotonic dystrophy 
E) Becker muscular dystrophy

Question 4

How are the clinical manifestations and onset of juvenile rheumatoid arthritis (JRA)different from rheumatoid arthritis (RA)in adults?

Accepted Answer

A)  JRA begins insidiously with systemic signs of inflammation. 
B)  JRA predominantly affects large joints. 
C)  JRA has more severe joint pain than RA. 
D)  JRA has a rapid onset of generalized aches as the first symptom. 
A)  JRA begins insidiously with systemic signs of inflammation. 
B)  JRA predominantly affects large joints. 
C)  JRA has more severe joint pain than RA. 
D)  JRA has a rapid onset of generalized aches as the first symptom.

Question 5

The normal lordotic curve of the lower spine begins to develop when the infant begins sitting.

Accepted Answer

A) True 
 B)False

Question 6

Unlike adult-onset arthritis,juvenile rheumatoid arthritis is not a syndrome that is often accompanied by systemic manifestations.

Accepted Answer

A) True 
 B)False

Question 7

Which disorder is characterized by failure of bones to ossify resulting in soft bones and skeletal deformity?

Accepted Answer

A)  Osteogenesis imperfecta 
B)  Rickets 
C)  Osteochondrosis 
D)  Perthes disease 
A)  Osteogenesis imperfecta 
B)  Rickets 
C)  Osteochondrosis 
D)  Perthes disease

Question 8

Osteosarcomas usually metastasize to the:

Accepted Answer

A)  pancreas. 
B)  liver. 
C)  lungs. 
D)  brain. 
A)  pancreas. 
B)  liver. 
C)  lungs. 
D)  brain.

Question 9

MATCHING
Match the type of muscular dystrophy with its description.The types may be used more than once.
-The face is expressionless and pouting of the lips makes whistling impossible

Accepted Answer

A) Duchenne muscular dystrophy 
B) Facioscapulohumeral muscular dystrophy 
C) Scapuloperoneal muscular dystrophy 
D) Myotonic dystrophy 
E) Becker muscular dystrophy 
A) Duchenne muscular dystrophy 
B) Facioscapulohumeral muscular dystrophy 
C) Scapuloperoneal muscular dystrophy 
D) Myotonic dystrophy 
E) Becker muscular dystrophy

Question 10

The appendicular skeleton grows faster than the axial skeleton during childhood.

Accepted Answer

A) True 
 B)False

Question 11

Which of the following muscular dystrophy syndromes develops from an X-linked recessive mode of inheritance?

Accepted Answer

A)  Duchenne 
B)  Facioscapulohumeral 
C)  Myotonic 
D)  Limb girdle 
A)  Duchenne 
B)  Facioscapulohumeral 
C)  Myotonic 
D)  Limb girdle

Question 12

Which protein,present in normal muscle cells and absent in muscle cells of Duchenne muscular dystrophy,mediates the anchoring of skeletal muscles fibers to the basement membrane?

Accepted Answer

A)  Syntrophin 
B)  Laminin 
C)  Dystrophin 
D)  Troponin 
A)  Syntrophin 
B)  Laminin 
C)  Dystrophin 
D)  Troponin

Question 13

Staphylococcus aureus may cause osteomyelitis in newborns and older children.

Accepted Answer

A) True 
 B)False

Question 14

What diagnosis is given when the infant's hip maintains contact with the acetabulum,but is not well seated within the hip joint?

Accepted Answer

A)  Dislocatable hip 
B)  Subluxated hip 
C)  Dislocated hip 
D)  Subluxable hip 
A)  Dislocatable hip 
B)  Subluxated hip 
C)  Dislocated hip 
D)  Subluxable hip

Question 15

Molecular analysis has demonstrated which oncogene associated with osteosarcoma?

Accepted Answer

A)  p53 
B)  src 
C)  myc 
D)  TSC2 
A)  p53 
B)  src 
C)  myc 
D)  TSC2

Question 16

Which serum laboratory test is elevated in all forms of osteogenesis imperfecta?

Accepted Answer

A)  Phosphorous 
B)  Calcium 
C)  Alkaline phosphatase 
D)  Total protein 
A)  Phosphorous 
B)  Calcium 
C)  Alkaline phosphatase 
D)  Total protein

Question 17

In scoliosis,curves in the thoracic spine greater than _____ degrees result in decreased pulmonary function.

Accepted Answer

A)  40 
B)  50 
C)  60 
D)  70 
A)  40 
B)  50 
C)  60 
D)  70

Question 18

An insufficient dietary intake of which vitamin can lead to rickets in children?

Accepted Answer

A)  Vitamin C 
B)  Vitamin B12 
C)  Vitamin B6 
D)  Vitamin D 
A)  Vitamin C 
B)  Vitamin B12 
C)  Vitamin B6 
D)  Vitamin D

Question 19

What is a cause of osteochondroses?

Accepted Answer

A)  Imbalance between calcitonin and parathyroid hormone 
B)  Nutritional deficiency of calcium and phosphorous 
C)  Bacterial infection of the bone 
D)  Vascular impairment and trauma to bone 
A)  Imbalance between calcitonin and parathyroid hormone 
B)  Nutritional deficiency of calcium and phosphorous 
C)  Bacterial infection of the bone 
D)  Vascular impairment and trauma to bone

Question 20

Which of the following is a very late sign or symptom of developmental dysplasia of the hip?

Accepted Answer

A)  Asymmetry of the gluteal or thigh folds 
B)  Leg length discrepancy 
C)  Waddling gait 
D)  Pain 
A)  Asymmetry of the gluteal or thigh folds 
B)  Leg length discrepancy 
C)  Waddling gait 
D)  Pain

Exam 41: Alterations of Musculoskeletal Function in Children

Which bones are affected in Legg-Calvé-Perthes disease?

If a child inherits facioscapulohumeral muscular dystrophy,she most likely inherited it from her:

MATCHING Match the type of muscular dystrophy with its description.The types may be used more than once. -Autosomal dominant with a slow rate of progression and frequent mental retardation

How are the clinical manifestations and onset of juvenile rheumatoid arthritis (JRA)different from rheumatoid arthritis (RA)in adults?

The normal lordotic curve of the lower spine begins to develop when the infant begins sitting.

Unlike adult-onset arthritis,juvenile rheumatoid arthritis is not a syndrome that is often accompanied by systemic manifestations.

Which disorder is characterized by failure of bones to ossify resulting in soft bones and skeletal deformity?

Osteosarcomas usually metastasize to the:

MATCHING Match the type of muscular dystrophy with its description.The types may be used more than once. -The face is expressionless and pouting of the lips makes whistling impossible

The appendicular skeleton grows faster than the axial skeleton during childhood.

Which of the following muscular dystrophy syndromes develops from an X-linked recessive mode of inheritance?

Which protein,present in normal muscle cells and absent in muscle cells of Duchenne muscular dystrophy,mediates the anchoring of skeletal muscles fibers to the basement membrane?

Staphylococcus aureus may cause osteomyelitis in newborns and older children.

What diagnosis is given when the infant's hip maintains contact with the acetabulum,but is not well seated within the hip joint?

Molecular analysis has demonstrated which oncogene associated with osteosarcoma?

Which serum laboratory test is elevated in all forms of osteogenesis imperfecta?

In scoliosis,curves in the thoracic spine greater than _____ degrees result in decreased pulmonary function.

An insufficient dietary intake of which vitamin can lead to rickets in children?

What is a cause of osteochondroses?

Which of the following is a very late sign or symptom of developmental dysplasia of the hip?

Cellular Biology

Altered Cellular and Tissue Biology

The Cellular Environment

Genes and Genetic Diseases

Genes, Environment-Lifestyle, and Common Diseases

Innate Immunity Including Inflammation

Adaptive Immunity

Alterations in Immunity and Inflammation Including Hypersensitivies

Infection Including Hivaids

Stress and Disease

Biology of Cancer

Tumor Invasion and Metastasis

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Concepts of Neurologic Dysfunction

Disorders of Neurologic Function

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Reproductive Systems

Alterations of the Reproductive Systems

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocyte Function

Alterations in Hematologic Function in Children

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Alterations of Leukocyte, Lymphoid, and Hemostatic Function

Alterations of Pulmonary Function in Children

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