Question 1

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

Accepted Answer

A)  C3bBb3b 
B)  C4b2a 
C)  C5b6789 
D)  C3b 
A)  C3bBb3b 
B)  C4b2a 
C)  C5b6789 
D)  C3b

Question 2

All of the following statements are true of C3 EXCEPT:

Accepted Answer

A)  It is known as the recognition unit. 
B)  It plays a key role in all pathways. 
C)  It is the most abundant of the complement proteins. 
D)  Its major function is opsonization. 
A)  It is known as the recognition unit. 
B)  It plays a key role in all pathways. 
C)  It is the most abundant of the complement proteins. 
D)  Its major function is opsonization.

Question 3

Which of the following is a characteristic of complement?

Accepted Answer

A)  It is activated by IgE in the classical pathway. 
B)  It cannot be activated by molecules other than antigen-antibody complexes. 
C)  It plays a role in the lysis of target cells coated with specific antibodies. 
D)  It is enhanced by decay accelerating factor. 
A)  It is activated by IgE in the classical pathway. 
B)  It cannot be activated by molecules other than antigen-antibody complexes. 
C)  It plays a role in the lysis of target cells coated with specific antibodies. 
D)  It is enhanced by decay accelerating factor.

Question 4

What is cleaved by C3bBb?

Accepted Answer

A)  C3 
B)  C5 
C)  C6 
A)  C3 
B)  C5 
C)  C6

Question 5

Which of the following act as opsonins?

Accepted Answer

A)  IgD 
B)  C3b 
C)  C5a 
D)  IL-2 
A)  IgD 
B)  C3b 
C)  C5a 
D)  IL-2

Question 6

Which factors are found in all three pathways?

Accepted Answer

A)  factors B and D 
B)  C4,C2,C3 
C)  C5-C9 
D)  C1qrs,C3,C5 
A)  factors B and D 
B)  C4,C2,C3 
C)  C5-C9 
D)  C1qrs,C3,C5

Question 7

Which of the following has perforin-like activity?

Accepted Answer

A)  IgG 
B)  IFN-gamma 
C)  C5b6789 
D)  C3b 
A)  IgG 
B)  IFN-gamma 
C)  C5b6789 
D)  C3b

Question 8

Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

Accepted Answer

A)  C2 
B)  C3 
C)  C4 
D)  factor B 
A)  C2 
B)  C3 
C)  C4 
D)  factor B

Question 9

Which complement protein is the key intermediate in all pathways?

Accepted Answer

A)  C4 
B)  C2 
C)  C3 
D)  C1 
A)  C4 
B)  C2 
C)  C3 
D)  C1

Question 10

Which factor must be associated with factor H to inactivate complement components?

Accepted Answer

A)  C1INH 
B)  factor I 
C)  DAF 
D)  CR1 
A)  C1INH 
B)  factor I 
C)  DAF 
D)  CR1

Question 11

A deficiency in complement component C2 would result in:

Accepted Answer

A)  increased vascular permeability 
B)  hereditary angioedema 
C)  severe infections with encapsulated bacteria 
D)  immune complex disease 
A)  increased vascular permeability 
B)  hereditary angioedema 
C)  severe infections with encapsulated bacteria 
D)  immune complex disease

Question 12

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Accepted Answer

A)  C1q,C1r,C1s 
B)  C4,C2 
C)  C5,C3 
D)  C5,C6,C7,C8 
A)  C1q,C1r,C1s 
B)  C4,C2 
C)  C5,C3 
D)  C5,C6,C7,C8

Question 13

Which complement component is found in both the classic and alternative pathways?

Accepted Answer

A)  C1 
B)  C2 
C)  factor B 
D)  C3 
A)  C1 
B)  C2 
C)  factor B 
D)  C3

Question 14

Which factor helps to dissociate C3b from red blood cells?

Accepted Answer

A)  factor B 
B)  DAF 
C)  C1INH 
D)  C5 
A)  factor B 
B)  DAF 
C)  C1INH 
D)  C5

Question 15

Lack of the complement components C5-C* may result in which disease?

Accepted Answer

A)  hereditary angioedema 
B)  paroxysmal nocturnal hemoglobinuria 
C)  atherosclerosis 
D)  meningitis 
A)  hereditary angioedema 
B)  paroxysmal nocturnal hemoglobinuria 
C)  atherosclerosis 
D)  meningitis

Question 16

Which of the following is able to activate complement?

Accepted Answer

A)  IgA 
B)  IgD 
C)  IgE 
D)  IgM 
A)  IgA 
B)  IgD 
C)  IgE 
D)  IgM

Question 17

Lack of the complement inhibitor C1INH results in which disease?

Accepted Answer

A)  hereditary angioedema 
B)  paroxysmal nocturnal hemoglobinuria 
C)  immune complex disease 
D)  meningitis 
A)  hereditary angioedema 
B)  paroxysmal nocturnal hemoglobinuria 
C)  immune complex disease 
D)  meningitis

Question 18

Which of the following are important functions of the complement system?

Accepted Answer

A)  lysis of foreign cells 
B)  increase in vascular permeability 
C)  clearance of antigen-antibody complexes 
D)  all of the above 
E)  all except one of the above 
A)  lysis of foreign cells 
B)  increase in vascular permeability 
C)  clearance of antigen-antibody complexes 
D)  all of the above 
E)  all except one of the above

Question 19

All of the following can trigger the alternative pathway EXCEPT:

Accepted Answer

A)  fungal cell walls 
B)  bacterial cell walls 
C)  yeast 
D)  antibody 
A)  fungal cell walls 
B)  bacterial cell walls 
C)  yeast 
D)  antibody

Question 20

Which factor is unique to the lectin pathway?

Accepted Answer

A)  factor B 
B)  C1q 
C)  mannose-binding protein 
D)  factor I 
A)  factor B 
B)  C1q 
C)  mannose-binding protein 
D)  factor I

Exam 6: Complement System

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

All of the following statements are true of C3 EXCEPT:

Which of the following is a characteristic of complement?

What is cleaved by C3bBb?

Which of the following act as opsonins?

Which factors are found in all three pathways?

Which of the following has perforin-like activity?

Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

Which complement protein is the key intermediate in all pathways?

Which factor must be associated with factor H to inactivate complement components?

A deficiency in complement component C2 would result in:

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Which complement component is found in both the classic and alternative pathways?

Which factor helps to dissociate C3b from red blood cells?

Lack of the complement components C5-C* may result in which disease?

Which of the following is able to activate complement?

Lack of the complement inhibitor C1INH results in which disease?

Which of the following are important functions of the complement system?

All of the following can trigger the alternative pathway EXCEPT:

Which factor is unique to the lectin pathway?

Introduction and Natural Immunity

Lymphoid System

Nature of Antigens and Major Histocompatibility Complex

Antibody Structure and Function

Cytokines

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

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